Results 81 to 90 of about 2,079,758 (368)

Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease [PDF]

, 2014
Multiple myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM ...
Blum B, Eriksen EF, Klein B, Lipton A, Mundy GR, Schmitt CP, Shay G   +6 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation

Journal of Clinical Investigation, 2018
Notch signaling critically controls cell fate decisions in mammals, both during embryogenesis and in adults. In the skeleton, Notch suppresses osteoblast differentiation and sustains bone marrow mesenchymal progenitors during postnatal life.
Seung-Yon Lee, Fanxin Long
semanticscholar   +1 more source

CD73‐generated adenosine promotes osteoblast differentiation [PDF]

Journal of Cellular Physiology, 2012
AbstractCD731 is a GPI‐anchored cell surface protein with ecto‐5′‐nucleotidase enzyme activity that plays a crucial role in adenosine production. While the roles of adenosine receptors (AR) on osteoblasts and osteoclasts have been unveiled to some extent, the roles of CD73 and CD73‐generated adenosine in bone tissue are largely unknown. To address this
Masahide, Takedachi, Hiroyuki, Oohara, Brenda J, Smith, Mitsuyoshi, Iyama, Mariko, Kobashi, Kenichiro, Maeda, Courtney L, Long, Mary B, Humphrey, Barbara J, Stoecker, Satoru, Toyosawa, Linda F, Thompson, Shinya, Murakami   +11 more
openaire   +2 more sources

Composite Electrospun Fibers Containing Optimized B‐ and Cu‐Doped Bioactive Glass Sol‐Gel Particles for Potential Soft Tissue Engineering Applications

Advanced Engineering Materials, EarlyView.
This article describes the preparation and characterization of poly(ε‐caprolactone) electrospun composite fibers incorporating sol‐gel‐derived bioactive glass particles doped with B and Cu. Scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, Fourier‐transform infrared spectroscopy, contact angle, acellular bioactivity, mechanical and ...
Elisa Piatti, Marta Miola, Liliana Liverani, Paolo Sartori, Enrica Verné, Aldo R. Boccaccini   +5 more
wiley   +1 more source

Eucommia ulmoides Oliver polysaccharide alleviates glucocorticoid-induced osteoporosis by stimulating bone formation via ERK/BMP-2/SMAD signaling

Scientific Reports
Osteoporosis (OP) is a metabolic disease characterized by low bone mineral mass owing to osteoblast dysfunction. Eucommia ulmoides Oliver (EuO) is a Chinese herbal medicine traditionally used to treat OP.
Jiyu Song, Yongfeng Zhang, Xinghui Jin, Yanfeng Zhu, Yutong Li, Min Hu   +5 more
doaj   +1 more source

BMP2-dependent gene regulatory network analysis reveals Klf4 as a novel transcription factor of osteoblast differentiation

Cell Death and Disease, 2021
Transcription factors (TFs) regulate the expression of target genes, inducing changes in cell morphology or activities needed for cell fate determination and differentiation.
Shuaitong Yu, Jinqiang Guo, Zheyi Sun, Chujiao Lin, Huangheng Tao, Qian Zhang, Yu Cui, Huanyan Zuo, Yuxiu Lin, Shuo Chen, Huan Liu, Zhi Chen   +11 more
doaj   +1 more source

MicroRNA-139-3p regulates osteoblast differentiation and apoptosis by targeting ELK1 and interacting with long noncoding RNA ODSM

Cell Death and Disease, 2018
Recent studies have confirmed that microRNAs and lncRNAs can affect bone cell differentiation and bone formation. In this study, miR-139-3p was upregulated in the femurs of hindlimb unloading mice and MC3T3-E1 cells under simulated microgravity; this ...
Yixuan Wang, Ke Wang, Zebing Hu, Hua Zhou, Lijun Zhang, Han Wang, Gaozhi Li, Shu Zhang, Xinsheng Cao, Fei Shi   +9 more
semanticscholar   +1 more source

Irisin Enhances Osteoblast DifferentiationIn Vitro [PDF]

International Journal of Endocrinology, 2014
It has been recently demonstrated that exercise activity increases the expression of the myokine Irisin in skeletal muscle, which is able to drive the transition of white to brown adipocytes, likely following a phenomenon of transdifferentiation. This new evidence supports the idea that muscle can be considered an endocrine organ, given its ability to ...
Graziana Colaianni, Concetta Cuscito, Teresa Mongelli, Angela Oranger, Giorgio Mori, Giacomina Brunetti, Silvia Colucci, Saverio Cinti, Maria Grano   +8 more
openaire   +4 more sources

Development and Preliminary In Vivo Study of 3D‐Printed Bioactive Glass Scaffolds with Trabecular Architecture

Advanced Engineering Materials, EarlyView.
This study reports the fabrication of trabecular bioactive glass scaffolds (composition “1d”: 46.1SiO2‐28.7CaO‐8.8MgO‐6.2P2O5‐5.7CaF2‐4.5Na2O wt%) through vat photopolymerization and the relevant results from mechanical testing and in vivo implantation procedures in rabbit femora, showing great promise for bone tissue engineering applications.
Dilshat Tulyaganov, Roberta Gabrieli, Avzal Akbarov, Nigora Nigmatova, Bekhzod Khabilov, Alessandro Schiavi, Martin Schwentenwein, Enrica Verné, Francesco Baino   +8 more
wiley   +1 more source