Results 111 to 120 of about 18,733 (222)

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Stromal Defense Against Cancer: An Unprecedented Mechanism Limiting Cancer Invasion Into the Bone

Cancer Science, Volume 117, Issue 2, Page 308-315, February 2026.
The roles of nonimmune systems in tumor regulation remain largely undefined. This article introduces a new concept, “stromal defense against cancer (SDAC),” which is based on recent findings that the periosteum actively responds to tumor proximity and physically impedes tumor invasion into bone.
Masayuki Tsukasaki, Hiroshi Takayanagi
wiley   +1 more source

Human breast cancer bone metastasis in vitro and in vivo: a novel 3D model system for studies of tumour cell-bone cell interactions. [PDF]

, 2015
Bone is established as the preferred site of breast cancer metastasis. However, the precise mechanisms responsible for this preference remain unidentified.
Avgoustou, P., Evans, C.A., Holen, I., Nutter, F., Ottewell, P.D., Wilkinson, J.M.   +5 more
core   +1 more source

Effect of metformin on inflammation and bone damage in a rat model of medication‐related osteonecrosis of the jaw

European Journal of Oral Sciences, Volume 134, Issue 1, February 2026.
Abstract This study investigated how chronic metformin administration modulates the cellular profile and inflammatory markers in a zoledronic acid‐based rat model of medication‐related osteonecrosis of the jaw (MRONJ). Male Wistar rats were allocated to different treatments: (i) naïve, (ii) MRONJ (zoledronic acid, 0.2 mg/kg, i.v.
Liviane Maria Alves Rabelo, Mariana Vasconcelos Guimarães, Aurilene Gomes Cajado, José Vitor Mota Lemos, Felipe Domingos de Sousa, Nylane Maria Nunes Alencar, Vilma de Lima, Paulo Goberlânio de Barros Silva, Ana Paula Negreiros Nunes Alves, Deysi Viviana Tenazoa Wong, Roberto César Pereira Lima‐Júnior   +10 more
wiley   +1 more source

Dynamics of Bone Trap-5b Level in Patients with Bone Metastases of Renal Cell Cancer at Combined Treatment [PDF]

, 2017
The objective of this study was to determine the sensitivity of tartrate-resistant acid phosphatase (Bone TRAP-5b) for early detection of bone metastases (BM) and to investigate the efficacy of bisphosphonates (BF) (zolendronic acid-ZA) in prevention of ...
Boichuk, S. (Serhiy), Diedkov, A. (Anatoliy), Kostiuk, V. (Viktor), Ostafiychuk, V. (Vasyliy)   +3 more
core   +2 more sources

Reader's digest of the pathophysiology of bone metastases [PDF]

, 2018
Summary: Bone metastases are a process originally proposed as the "seed and soil theory” in the eighteenth century. Tumor cell disseminating from patients with breast or prostate cancer typically use the bony environment to grow outside the primary tumor
Gruber, Reinhard
core  

Cortactin (CTTN) overexpression in osteosarcoma correlates with advanced stage and reduced survival [PDF]

, 2011
The cortactin (CTTN) gene has been found, by transcriptomic profiling, to be overexpressed in pediatric osteosarcoma. The location of CTTN at 11q13 and the role of cortactin in cytoskeleton restructuring make CTTN of interest as a ...
Folio, C. (Cecilia), Lecanda, F. (Fernando), Ormazábal, C. (Cristina), Patiño-García, A. (Ana), Rivas, J. (Javier) de las, San-Julian, M. (Mikel), Sierrasesumaga, L. (Luis), Toledo, G. (Gemma), Zalacain, M. (Marta), Zandueta, C. (Carolina)   +9 more
core  

PTHrP treatment of colon cancer cells promotes tumor associated-angiogenesis by the effect of VEGF [PDF]

, 2019
We showed that Parathyroid Hormone-related Peptide (PTHrP) induces proliferation, migration, survival and chemoresistance via MAPKs and PI3K/AKT pathways in colorectal cancer (CRC) cells.
Calvo, Natalia Graciela, Carriere, Pedro Matias, Gentili, Claudia Rosana, Gigola, Graciela, Martín, María Julia   +4 more
core   +1 more source

Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases [PDF]

, 2015
PURPOSE: Bone metastases secondary to solid tumors increase the risk of skeletal-related events (SREs), including the occurrence of pathological fracture (PF), radiation to bone (RB), surgery to bone (SB), and spinal cord compression (SCC).
A Hussain, A Lipton, A Lipton, Ada Braun, Alison Stopeck, AM Abdulhalim, Arun Balakumaran, AT Stopeck, Blair Egerdie, C Nieder, Charles Cleeland, CS Cleeland, CS Cleeland, CS Cleeland, CS Cleeland, D Henry, Danail Damyanov, DF Cella, DH Henry, Donald L. Patrick, E Chow, F Saad, Felipe Salvador Palazzo, G Oster, Gavin Marx, GD Roodman, GR Mundy, GV Scagliotti, JA Ford, Janet Brown, Jean-Jacques Body, K Cetin, K Fizazi, K Fizazi, K Lemay, K Webster, KC Chung, L Costa, L Costa, L Costa, Lesley Fallowfield, LS Rosen, M Maltoni, M Norgaard, M Yong, MR Smith, N Sathiakumar, N Sathiakumar, R Moos von, R Moos von, RE Coleman, RE Coleman, Roger von Moos, S Vadhan-Raj, Yi Qian, Ying Zhou   +55 more
core   +2 more sources

Rectal carcinoid tumor with bone marrow and osteoblastic bone metastasis: a case report.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2009
Rectal carcinoids comprise 12.6% of all carcinoid tumors and represent the third largest group of the gut carcinoids. A 64-year-old woman was diagnosed as high-grade neuroendocrine carcinoma. She had liver, bone, and bone marrow metastasis. Carcinoid syndrome was diagnosed due to diarrhea, nausea, vomiting, tachycardia, and high level of 24-hour ...
Metin, Ozkan, Ozlem, Er, I Okkeş, Karahan, Kemal, Deniz, Ramazan, Coşkun, Can, Küçük, Alper, Yurci, Mustafa, Altinbaş   +7 more
openaire   +1 more source