Results 71 to 80 of about 18,733 (222)

A novel patient-derived intra-femoral xenograft model of bone metastatic prostate cancer that recapitulates mixed osteolytic and osteoblastic lesions

Journal of Translational Medicine, 2011
Prostate cancer metastasizes to bone in the majority of patients with advanced disease leading to painfully debilitating fractures, spinal compression and rapid decline.
Raheem Omer, Kulidjian Anna A, Wu Christina, Jeong Young B, Yamaguchi Tomonori, Smith Kristen M, Goff Daniel, Leu Heather, Morris Sheldon R, Cacalano Nicholas A, Masuda Koichi, Jamieson Catriona HM, Kane Christopher J, Jamieson Christina AM   +13 more
doaj   +1 more source

The RANK/RANKL/OPG system and tumor bone metastasis: Potential mechanisms and therapeutic strategies

Frontiers in Endocrinology, 2022
With the markedly increased diagnosis and incidence of cancer in the population, tumor bone metastasis has become a frequent event in tumor patients. Healthy bone integrity is maintained by a delicate balance between bone formation and bone resorption ...
Yan Zhang, Jingqi Liang, Peilong Liu, Qiong Wang, Liang Liu, Hongmou Zhao   +5 more
doaj   +1 more source

Genetically engineered pre-microRNA-34a prodrug suppresses orthotopic osteosarcoma xenograft tumor growth via the induction of apoptosis and cell cycle arrest. [PDF]

, 2016
Osteosarcoma (OS) is the most common primary malignant bone tumor in children, and microRNA-34a (miR-34a) replacement therapy represents a new treatment strategy. This study was to define the effectiveness and safety profiles of a novel bioengineered miR-
Qiu, Jing-Xin, Tu, Mei-Juan, Wang, Wei-Peng, Yu, Ai-Ming, Yu, Ai-Xi, Zhao, Yong   +5 more
core   +2 more sources

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

Mouse models for studying prostate cancer bone metastasis. [PDF]

, 2016
Once tumor cells metastasize to the bone, the prognosis for prostate cancer patients is generally very poor. The mechanisms involved in bone metastasis, however, remain elusive, because of lack of relevant animal models.
Dai, J., Hensel, J., Kruithof-de Julio, M., Shiozawa, Y., Wang, N.   +4 more
core   +1 more source

Plant‐derived extracellular vesicle‐like particles as novel osteoanabolic agents: Activating bone morphogenetic protein 2/Smads signaling axis for bone regeneration in postmenopausal osteoporosis

Interdisciplinary Medicine, EarlyView.
Illustration depicting the isolation of Dipsaci Radix derived extracellular vesicle‐like particles and their function in alleviating osteoporosis. (A) Extraction and characterization detection process of extracellular vesicle‐like particles derived from Dipsaci Radix roots. (B) Cell experiments in vitro, Dipsaci Radix derived extracellular vesicle‐like
Qing Zhao, Yue Cao, Zhengting Wu, Yingqi Cao, Qi You, Yuanyuan Xia, Xuejun Tan, Dongxiao Li, Tianxin Qiu, Xiuping Cai, Zhaodi Guo, Lei Zheng, Kewei Zhao   +12 more
wiley   +1 more source

Prostate Osteoblast-Like Cells: A Reliable Prognostic Marker of Bone Metastasis in Prostate Cancer Patients [PDF]

Contrast Media & Molecular Imaging, 2018
The main aim of this study was to investigate the putative association among the presence of prostate cancer cells, defined as prostate osteoblast-like cells (POLCs), and showing the expression of typical morphological and molecular characteristics of osteoblasts, the development of bone metastasis within 5 years of diagnosis, and the uptake of 18F ...
Scimeca M., Urbano N., Rita B., Mapelli S. N., Catapano C. V., Carbone G. M., Ciuffa S., Tavolozza M., Schillaci O., Mauriello A., Bonanno E.   +10 more
openaire   +4 more sources

CDH11 Expression is Associated with Survival in Patients with Osteosarcoma [PDF]

, 2008
Previous studies have shown that cadherin-11 (CDH11) may be involved in the metastatic process of osteosarcoma. The correlation of the expression levels of CDH11 in osteosarcoma samples with the risk of disease progression and metastasis
Bruheim, S. (Skjalg), Fodstad, O. (Oystein), Ju, J. (Jingfang), Lecanda, F. (Fernando), Muller, C. (Christoph), Nakajima, G. (Go), Patiño-García, A. (Ana), San-Julian, M. (Mikel), Sierrasesumaga, L. (Luis), Xi, Y. (Yaguang)   +9 more
core  

Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype. [PDF]

, 2016
The αvβ3 integrin is known to be highly upregulated during cancer progression and promotes a migratory and metastatic phenotype in many types of tumors.
Fedele, Carmine, Keen, James H., Languino, Lucia R., Lu, Huimin, Nevalainen, Marja T., Singh, Amrita   +5 more
core   +2 more sources

Molecular theranostics: principles, challenges and controversies

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 156-164, March 2025.
Molecular theranostics offers a powerful tool to drive precision medicine in nuclear oncology. While theranostics is not a new principle in nuclear medicine, recent advances in instrumentation and radiopharmacy have driven a reinvigoration and a broader suite of applications.
Geoffrey Currie
wiley   +1 more source