Results 81 to 90 of about 18,733 (222)

The Usefulness of Bone Biomarkers for Monitoring Treatment Disease: A Comparative Study in Osteolytic and Osteosclerotic Bone Metastasis Models

Translational Oncology, 2017
BACKGROUND: The skeleton is the most common site of colonization by metastatic cancers. Zoledronic acid (ZA) has been shown to be effective for the treatment of bone metastases regardless of whether the bone lesions are osteolytic or osteoblastic ...
Marta Martín-Fernández, Karmele Valencia, Carolina Zandueta, Cristina Ormazábal, Susana Martínez-Canarias, Fernando Lecanda, Concepción de la Piedra   +6 more
doaj   +1 more source

New molecular targets in bone metastases [PDF]

, 2010
Bone metastases have a major impact on morbidity and on mortality in cancer patients. Despite its clinical relevance, metastasis remains the most poorly elucidated aspect of carcinogenesis.
Colucci, G., Fratto, M., Galluzzo, S., Gucciardino, C., LOMBARDI, LUCIO, Maiello, E., Pantano, F., Riva, E., RIZZO, Sergio, RUSSO, Antonio, SANTINI, Daniele, Silvestris, N., Tonini, G., Vincenzi, B., Zoccoli, A.   +14 more
core   +1 more source

Dickkopf‐1 (DKK‐1) stimulated prostate cancer growth and metastasis and inhibited bone formation in osteoblastic bone metastases [PDF]

The Prostate, 2010
AbstractBACKGROUNDOsteoblastic bone metastasis is the predominant phenotype observed in prostate cancer patients and is associated with high patient mortality and morbidity. However, the mechanisms determining the development of this phenotype are not well understood.
Thudi, Nanda K., Martin, Chelsea K., Murahari, Sridhar, Shu, Sherry T., Lanigan, Lisa G., Werbeck, Jillian L., Keller, Evan T., McCauley, Laurie K., Pinzone, Joseph J., Rosol, Thomas J.   +9 more
openaire   +3 more sources

Vascular Reconstruction in Extremity Soft Tissue Sarcomas: A Systematic Review and Single‐Arm Meta‐Analysis

Journal of Surgical Oncology, EarlyView.
ABSTRACT Introduction The management of extremity soft tissue sarcomas (STS) involving major vessels presents unique challenges, historically leading to amputation. Advances in vascular reconstruction have enabled limb‐sparing surgery (LSS), but outcomes and perioperative risks remain uncertain.
Lucas Monteiro Delgado, Bernardo Fontel Pompeu, Vinícius dos Santos Macedo, Gabriel Henrique Acedo Martins, Eric Pasqualotto, Matheus Reginato Araujo, Julia Hoici Brunini, Victor Andrade Nunes, Cláudia Theis, Samuel Aguiar Junior   +9 more
wiley   +1 more source

Deregulated molecules and pathways in the predisposition and dissemination of breast cancer cells to bone

Computational and Structural Biotechnology Journal, 2022
Background: Bone metastasis is the most common metastatic destination in advanced breast cancer, presenting a poor prognosis and clinical challenges in management.
Laijian Sui, Andrew Sanders, Wen G. Jiang, Lin Ye   +3 more
doaj   +1 more source

Metaplastic woven bone in bone metastases: A Fourier-transform infrared analysis and imaging of bone quality (FTIR) [PDF]

, 2018
Most osteolytic tumors are in fact mixed and contain an osteoblastic component associated with the predominant osteolytic areas. This metaplastic woven bone is always evidenced by histological analysis even in the absence of radiological expression ...
A. Tahla, C. Masson, D. Chappard, E. Legrand, G. Mabilleau   +4 more
core   +3 more sources

The osteoblast in regulation of tumor cell dormancy and bone metastasis

Journal of Bone Oncology
Breast and prostate cancer are among the most common malignancies worldwide. After treatment of the primary tumor, distant metastases often occur after a long disease-free interval. Bone is a major site for breast and prostate cancer metastasis and approximately 70% of patients with advanced disese suffer from osteolytic or osteoblastic bone metastases,
Jennifer Zarrer, Hanna Taipaleenmäki
openaire   +3 more sources

Hidden Insights: Comprehensive Radiological Analysis of Four Skeletal Populations From 13th–19th Century Southern Finland Reveals Neoplastic and Other Lesions Invisible on Bone Surfaces

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT This study aims to identify lesions confined to the internal structures of bones. A radiographic analysis was performed on 219 archaeological, historical period skeletons from southern Finland. Although the study examines nearly all preserved skeletal elements using plain radiographs, it does not incorporate computed tomography.
Kati Salo, Anna Föhr, Rimantas Jankauskas   +2 more
wiley   +1 more source

Basic and clinical associations between bone and cancer

Immunological Medicine, 2020
Bone is one of the most common distant organs in which tumor cells tend to metastasize depending on complicated immune system and bone microenvironments.
Fang He, Yoshinori Matsumoto
doaj   +1 more source

Immunohistochemical investigation of cell cycle and apoptosis regulators (Survivin, beta-Catenin, P53, Caspase 3) in canine appendicular osteosarcoma [PDF]

, 2012
Background: Osteosarcoma (OSA) represents the most common canine primary bone tumour. Despite several pathways have been investigated so far, few molecules have been identified as prognostic tools or potential therapeutic targets, and there is still the ...
Bongiovanni, Laura, Buracco, Paolo, Ciccarelli, Andrea, De Maria, Raffaella, Della Salda, Leonardo, Malatesta, Daniela, Maniscalco, Lorella, Martano, Marina, Mazzocchetti, Francesca, Morello, Emauela, Palmieri, Chiara, Romanucci, Mariarita   +11 more
core   +4 more sources