Results 21 to 30 of about 82,535 (276)
Notch 1 Impairs Osteoblastic Cell Differentiation [PDF]
Endocrinology, 2003 Notch receptors are single pass transmembrane receptors activated by membrane-bound ligands with a role in cell proliferation and differentiation. As Notch 1 and 2 mRNAs are expressed by osteoblasts and induced by cortisol, we postulated that Notch could regulate osteoblastogenesis.
Maria, Sciaudone +4 more
openaire +2 more sources
Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts [PDF]
, 2019 Despite recent progress in its treatment, Multiple Myeloma (MM) remains incurable and its associated bone disease persists even after complete remission.
Atkinson, Emily G. +7 more
core +1 more source
Involvement of microRNAs in regulation of osteoblastic differentiation in mouse induced pluripotent stem cells. [PDF]
PLoS ONE, 2012 UNLABELLED: BACKGOROUND: MicroRNAs (miRNAs), which regulate biological processes by annealing to the 3'-untranslated region (3'-UTR) of mRNAs to reduce protein synthesis, have been the subject of recent attention as a key regulatory factor in cell ...
Hideharu Okamoto +5 more
doaj +1 more source
Frontiers in Oncology, 2021 Osteosarcoma (OS), which occurs most commonly in adolescents, is associated with a high degree of malignancy and poor prognosis. In order to develop an accurate treatment for OS, a deeper understanding of its complex tumor microenvironment (TME) is ...
Yun Liu +47 more
doaj +1 more source
Mesenchymal Stem Cell Spheroids Retain Osteogenic Phenotype Through α2β1 Signaling. [PDF]
, 2016 Unlabelled: The induction of mesenchymal stem cells (MSCs) toward the osteoblastic lineage using osteogenic supplements prior to implantation is one approach under examination to enhance their bone-forming potential.
Harvestine, Jenna N +4 more
core +1 more source
Primary osteoblasts, osteoblast precursor cells or osteoblast‐like cell lines: Which human cell types are (most) suitable for characterizing 45S5‐bioactive glass? [PDF]
Journal of Biomedical Materials Research Part A, 2019 AbstractThe question how bioactive glasses (BGs) influence the viability and osteogenic differentiation of human osteogenic cells has already been addressed by several studies. However, a literature review revealed great differences in the type of cells used for these experiments.
Sebastian Wilkesmann +6 more
openaire +3 more sources
RAGE Signaling in Skeletal Biology [PDF]
, 2019 PURPOSE OF REVIEW: The receptor for advanced glycation end products (RAGE) and several of its ligands have been implicated in the onset and progression of pathologies associated with aging, chronic inflammation, and cellular stress. In particular, the
Davis, Hannah M. +2 more
core +2 more sources
Grasas y Aceites, 2014 The aim of this study was, first, to investigate the influence of olive variety and elevation of orchards on the phenolic compound content of Sicilian virgin olive oils (VOOs) and, second, to investigate the effects of VOO phenolic extracts on osteoblast
O. García-Martínez +4 more
doaj +1 more source
Life, 2021 Coupling between osteoblast-mediated bone formation and osteoclast-mediated bone resorption maintains both mechanical integrity and mineral homeostasis. Zinc is required for the formation, mineralization, growth, and maintenance of bones. We examined the
Jin-Ho Park +7 more
doaj +1 more source
Fluoride Increases Superoxide Production and Impairs the Respiratory Chain in ROS 17/2.8 Osteoblastic Cells [PDF]
, 2014 It is known that fluoride produces oxidative stress. Inflammation in bone tissue and an impairment of the respiratory chain of liver have been described in treatments with fluoride. Whether the impairment of the respiratory chain and oxidative stress are
Fina, Brenda +3 more
core +1 more source