Results 241 to 250 of about 136,319 (308)

Epigenetic transcriptional regulation of skeletal aging: The emerging role of m⁶A methylation. [PDF]

J Orthop Translat
Song C, Song G, Zhang S, Zhao H, Wen Z, Chen Y, Chen X, Liu B, Ni Q, Fan D.   +9 more
europepmc   +1 more source

Advanced Molecular Imaging Probes for Skeletal Diseases: Current Progress and Future Perspectives

iRADIOLOGY, EarlyView.
This review summarizes the potential molecular imaging techniques and probes for common orthopedic diseases, such as trauma, infection, metabolism, tumor, joint, spine and other fields, aiming to provide a basis for the development of a new generation of molecular imaging probes.
Shuo Guo, Yuling Cui, Zhiye Fan, Chenxin Jiang, Bowen Fu, Guangbin Cui, Yanli He   +6 more
wiley   +1 more source

In vitro characterization of osteoblasts from craniofacial fibrous dysplasia of bone and their impact on bone homeostasis. [PDF]

Orphanet J Rare Dis
Sergheraert J, Dumortier C, Guillaume C, Laurence S, Bornert F, Gangloff SC, Mauprivez C, Velard F.   +7 more
europepmc   +1 more source

New Approach Methodologies (NAMs) in Alternative Methods: A Comparative Cytotoxicity Analysis of Nanostructured Hydroxyapatite in Adipose Stem Cells Spheroids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Toxicological assessment is essential in NP approval for health and medical applications. Although 2D cell culture has been widely used, 3D models, especially spheroids, provide better predictive value for toxicological risk assessments since they replicate complex cellular interactions more accurately.
Bianca Montenegro, Rosângela Mayer Gonçalves, Marcelle Gomes Pegurier, Isabelle Amorim, Alexandre Malta Rossi, Leandra Santos Baptista   +5 more
wiley   +1 more source

Osteocytic Pink1/Prkn modulates M6P metabolism and contributes to GC-induced bone loss. [PDF]

J Orthop Translat
Mei J, Zheng Z, Liu D, Zhou J, Gao C, Ma Y, Ding P, Gao J, Huang Y, Yin J.   +9 more
europepmc   +1 more source

Reconceptualizing Aplastic Anemia—Seed, Worm, Soil

Journal of Clinical Laboratory Analysis, EarlyView.
Aplastic anemia (AA) encompasses a group of hematological syndromes often misdiagnosed, resulting in a decrease in the overall blood cell count and representing a form of bone marrow failure. We reinterpret AA based on the “seed, worm, and soil” doctrine.
Xintong Xu, Zining Wang, Jiaming Hu, Chunyan Liu, Rong Fu   +4 more
wiley   +1 more source

PD0325901 alleviates thrombin-inhibited osteogenic differentiation through an IL-1β-activated feedback loop between MEK-Erk1/2 and NF-κB signal pathways: insights from bioinformatics and experimental verification. [PDF]

Front Immunol
Ge YS, Huang CM, Shen J, Meng TT, Zhao MJ, Yin JL, Huang XH, Chen LL, Luo JH, Zhai YQ, Du JW, Wang YL, Wang XZ, Sun PP, Ding DF.   +14 more
europepmc   +1 more source

Effects of testosterone and high‐dose anabolic steroids on orthodontic‐induced bone remodeling and root resorption: An animal study

Journal of Periodontology, EarlyView.
Abstract Background This study investigates the impact of disruptions in testosterone levels on bone remodeling, root resorption, and periodontal ligament (PDL) during orthodontic tooth movement (OTM) in a pubertal male rat model. Methods Testosterone deficiency was induced through orchiectomy, and the anabolic‐androgenic steroid (AAS, testosterone ...
Caio Luiz Bitencourt Reis, Kelly Galisteu‐Luiz, Gabriela Leite Pedroso, Gustavo Lopes Puls, Leticia Cassaro, Bruno Boaventura Vieira, Fábio Lourenço Romano, Erika Calvano Küchler, Christian Kirschneck, Daniela Silva Barroso de Oliveira, Maria Bernadete Sasso Stuani, Mirian Aiko Nakane Matsumoto   +11 more
wiley   +1 more source

Macrophage polarization regulates bone homeostasis: a potential etiology and therapy for postmenopausal osteoporosis. [PDF]

Front Immunol
Danzeng Q, Wu F, Cui M, Shen Y, Li Y, Jiao J, Jiang W.   +6 more
europepmc   +1 more source