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Sex Differences in Metabolic and Behavioral Responses to Exercise but Not Exogenous Osteocalcin Treatment in Mice Fed a High Fat Diet [PDF]
Frontiers in Physiology, 2022 BackgroundExercise helps improve glucose handling in diabetes and has been shown to improve mood and cognition in other conditions. Osteocalcin, a protein produced by bone osteoblasts, was reported to have endocrine actions to improve both metabolism and
Jordan Winberg +5 more
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Osteocalcin is necessary and sufficient to maintain muscle mass in older mice
Molecular Metabolism, 2016 Objective: A decrease in muscle protein turnover and therefore in muscle mass is a hallmark of aging. Because the circulating levels of the bone-derived hormone osteocalcin decline steeply during aging in mice, monkeys and humans we asked here whether ...
Paula Mera, Gerard Karsenty
exaly +3 more sources
Osteocalcin: Beyond Bones [PDF]
Endocrinology and MetabolismApart from basic roles such as supporting the body, protecting internal organs, and storing calcium, the skeletal system also performs hormonal functions. In recent years, several reports have been published on proteins secreted by bones and their impact
Jakub Krzysztof Nowicki +1 more
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Scientific ReportsThis study aims to discover the association between serum osteocalcin, the Chinese visceral adiposity index (CVAI), and atherosclerotic cardiovascular disease (ASCVD) risk, and their impact on arterial stiffness in T2DM patients.
Caixia Gong +9 more
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Science-Business eXchange, 2011 Osteocalcin, or bone Gla protein, is a small protein secreted by osteoblasts that can undergo γ-carboxylation. The γ-carboxylated form binds hydroxyapatite and is abundant in bone extracellular matrix. In contrast, the undercarboxylated circulating form has been implicated as a novel hormone and positive regulator of glucose homeostasis.
Kapustin, Alexander N. +1 more
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ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», 2020 В качестве общего итога современных биомедицинских исследований стало привычным обнаруживать корреляциенные связи «всего со всем». Четверть вековая история изучения остеокальцина - пример, подтверждающий эту тенденцию. За 25 лет научный статус вещества прогрессировал от белка с неизвестной функцией, просто присутствующего на второй по содержанию ...
openaire +3 more sources
International Journal of Endocrinology, 2021 Previous studies found that thyroid hormones stimulate osteoblast-like cells to secrete osteocalcin. We aimed to investigate the association between serum thyroid hormone and serum osteocalcin in euthyroid population.
Xiaomin Nie +5 more
doaj +1 more source
Heliyon, 2023 Objective: Basic medical studies have reported an improved effect of osteocalcin on cognition. We explored the causal link between osteocalcin and dementia via the implementation of Mendelian randomization methodology.
Wangmi Liu +4 more
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The relationship between plasma total testosterone and osteocalcin levels in males with newly diagnosed type 2 diabetes [PDF]
Zhenduanxue lilun yu shijian, 2021 Objective: To explore the relationship between plasma total testosterone and osteocalcin levels in males with newly diagnosed type 2 diabetes. Methods: A total of 146 males with newly diagnosed type 2 diabetes mellitus admitted from January 2018 through ...
WANG Guangyu, YANG Xin, ZHANG Lijuan, TAN Jiaorong
doaj +1 more source
Experimental Gerontology, 2023 This study aimed to investigate the effects and mechanisms of osteocalcin on autophagy in myoblasts, as well as its possible therapeutic effects in aging muscle.
Pengying Gu +6 more
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