Results 121 to 130 of about 130,158 (334)

Mediators of mechanotransduction between bone cells [PDF]

open access: yes, 2009
Mechanical forces are known to regulate the function of tissues in the body, including bone. Bone adapts to its mechanical environment by altering its shape and increasing its size in response to increases in mechanical load associated with exercise, and
Komarova, S. V.   +4 more
core  

Effect of medium pH on osteoclast activity and osteoclast formation in cultures of dispersed rabbit osteoclasts

open access: yesJournal of Bone and Mineral Research, 1993
Abstract We investigated the effect of medium pH on activity of isolated osteoclasts and have also looked at the possibility that medium pH affects osteoclast numbers during culture. Osteoclast-containing cell suspensions prepared from neonatal rabbits were cultured on bovine bone slices at pH 6.5, 7.0, or 7.5.
Toshiaki Shibutani, J. N. M. Heersche
openaire   +2 more sources

Pinosylvin Inhibits Inflammatory and Osteoclastogenesis via NLRP3 Inflammasome

open access: yesAdvanced Science, EarlyView.
Pinosylvin blocks LPS and RANKL induced NEK7/NLRP3 interaction, inhibiting NLRP3 inflammasome oligomerization and assembly, reducing IL‐1β maturation and GSDMD cleavage, and improving the inflammatory microenvironment and abnormal osteoclastogenesis. Abstract Pro‐inflammatory cytokines such as TNF, IL‐1, and IL‐6 trigger aberrant osteoclastogenesis and
Wei Zhang   +13 more
wiley   +1 more source

Interleukin-7 Induces Osteoclast Formation via STAT5, Independent of Receptor Activator of NF-kappaB Ligand

open access: yesFrontiers in Immunology, 2017
Interleukin-7 (IL-7), which is required for the development and survival of T cells in the thymus and periphery, plays a role in joint destruction. However, it remains unclear how IL-7 affects osteoclast formation.
Jin-Hee Kim   +32 more
doaj   +1 more source

Irisin‐Loaded Cerium‐Containing Mesoporous Bioactive Glass for Effective Immunomodulation and Odontogenesis of Dental Pulp Cells

open access: yesAdvanced Science, EarlyView.
The Irisin/Ce‐MBGNs delivery system can slowly release myokine Irisin for vital pulp therapy. Irisin/Ce‐MBGNs can enhance mitochondrial function and promote the differentiation of inflammatory macrophages toward M2‐Mφ, thereby regulating the immune response mechanism of inflamed dental pulp.
Mingxin Wang   +9 more
wiley   +1 more source

An inducible explant model of osteoclast-osteoprogenitor coordination in exacerbated osteoclastogenesis

open access: yesiScience, 2023
Summary: Elucidating a basic blueprint of osteoclast-osteoblast coordination in skeletal remodeling and understanding how this coordination breaks down with age and disease is essential for addressing the growing skeletal health problem in our aging ...
Jarred M. Whitlock   +4 more
doaj  

IL-11 produced by breast cancer cells augments osteoclastogenesis by sustaining the pool of osteoclast progenitor cells

open access: yesBMC Cancer, 2013
Background Interleukin (IL)-11, a cytokine produced by breast cancer, has been implicated in breast cancer-induced osteolysis (bone destruction) but the mechanism(s) of action remain controversial.
McCoy Erin M   +3 more
doaj   +1 more source

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