Results 121 to 130 of about 182,622 (382)

Echinococcus granulosus sensu lato promotes osteoclast differentiation through DUSP4-MAPK signaling in osseous echinococcosis

Frontiers in Microbiology
IntroductionOsseous echinococcosis, caused by Echinococcus granulosus infection, is characterized by progressive bone destruction driven by abnormal osteoclast activation.
Haohao Sun, Yaqing Liu, Yaqing Liu, Yiping Huang, Kangjun Xiong, Zhendong Zhang, Weishan Wang, Yi Dai, Jing Li, Qi Li, Sibo Wang, Chenhui Shi   +11 more
doaj   +1 more source

Antisense Sense in Osteoclasts [PDF]

The American Journal of Pathology, 2016
This commentary highlights the article by Li et al that proposes regulating Wilm's tumor-1 antisense RNA to control pathological bone resorption.
openaire   +4 more sources

Signaling Pathways in Osteoclast Differentiation

Chonnam medical journal, 2016
Osteoclasts are multinucleated cells of hematopoietic origin that are responsible for the degradation of old bone matrix. Osteoclast differentiation and activity are controlled by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and ...
Jung Ha Kim, Nacksung Kim
semanticscholar   +1 more source

Fluid Shear‐Controlled Pro/Anti‐Inflammatory Osteomodulatory Construct for Drug‐Free Immune Activation Through Cationic Ion Channel Activation

Advanced Healthcare Materials, EarlyView.
A 3D‐printed PCL scaffold coated with Arginine was laminated with electrospun polyvinyl alcohol (PVA) nanofibers containing cationic cellulose nanocrystals (PVA@cCNC). This created nanoisland‐like regions of aligned and random cCNC‐rich fibers. The composite scaffold, under fluid shear stimulation, modulated macrophage polarization from M1 to M2 ...
Keya Ganguly, Aayushi Randhawa, Sayan Deb Dutta, Jieun Lee, Youjin Seol, Mehran Mohammad Hossein Pour, Tejal V. Patil, Rumi Acharya, Ki‐Taek Lim   +8 more
wiley   +1 more source

Periodontal ligament cells-derived exosomes promote osteoclast differentiation via modulating macrophage polarization

Scientific Reports
Several studies have demonstrated that exosomes (Exos) are involved in the regulation of macrophage polarization and osteoclast differentiation. However, the characteristics as well as roles of exosomes from human periodontal ligament cells (hPDLCs-Exos)
Xinyi Bai, Yingxue Wang, Xinyuan Ma, Yingying Yang, Cong Deng, Mengling Sun, Chen Lin, Linkun Zhang   +7 more
doaj   +1 more source

STAT3 controls osteoclast differentiation and bone homeostasis by regulating NFATc1 transcription

Journal of Biological Chemistry, 2019
The transcription factor signal transducer and activator of transcription 3 (STAT3) plays a central role in cell survival and function. STAT3 has been demonstrated to participate in the maintenance of bone homeostasis in osteoblasts, but its role in ...
Yiling Yang, M. Chung, Siru Zhou, X. Gong, Hongyuan Xu, Yueyang Hong, A. Jin, Xiangru Huang, Weiguo Zou, Q. Dai, Lingyong Jiang   +10 more
semanticscholar   +1 more source

Phagocytosis by osteoclasts [PDF]

The Anatomical Record, 1917
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openaire   +2 more sources

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, EarlyView.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source

RANK is essential for osteoclast and lymph node development.

Genes & Development, 1999
The physiological role of the TNF receptor (TNFR) family member, RANK, was investigated by generating RANK-deficient mice. RANK(-/-) mice were characterized by profound osteopetrosis resulting from an apparent block in osteoclast differentiation.
W. Dougall, M. Glaccum, K. Charrier, Kathy Rohrbach, K. Brasel, T. D. Smedt, E. Daro, Jeffery Smith, Mark E. Tometsko, C. Maliszewski, A. Armstrong, Victor Shen, S. Bain, D. Cosman, Dirk M. Anderson, P. Morrissey, J. Peschon, J. Schuh   +17 more
semanticscholar   +1 more source

Development of Bone Targeting Drugs. [PDF]

, 2017
The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage
Alméciga-Díaz, Carlos J., Mackenzie, William G., Mason, Robert W., Orii, Tadao, Sawamoto, Kazuki, Stapleton, Molly, Tomatsu, Shunji   +6 more
core   +2 more sources