Results 141 to 150 of about 182,622 (382)

Calcium signaling in osteoclasts

open access: yesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011
It has long been known that many bone diseases, including osteoporosis, involve abnormalities in osteoclastic bone resorption. As a result, there has been intense study of the mechanisms that regulate both the differentiation and bone resorbing function of osteoclast cells.
James W. Putney, Sung-Yong Hwang
openaire   +3 more sources

3D‐Printed Multidimensional Bionic Mg‐MC/PLGA Composite for Tailored Repair of Segmental Long Bone Defects

open access: yesAdvanced Healthcare Materials, EarlyView.
This study develops 3D‐printed Mg‐MC/PLGA scaffolds with varying Mg concentrations (0–20%). The 5% Mg scaffold shows optimal cytocompatibility, osteogenic activity in vitro, and significantly enhances bone regeneration in rabbits, improving bone volume and mechanical strength.
Shihang Liu   +9 more
wiley   +1 more source

Key Triggers of Osteoclast-Related Diseases and Available Strategies for Targeted Therapies: A Review

open access: yesFrontiers in Medicine, 2017
Osteoclasts, the only cells with bone resorption functions in vivo, maintain the balance of bone metabolism by cooperating with osteoblasts, which are responsible for bone formation.
Haidi Bi   +7 more
semanticscholar   +1 more source

Mediators of mechanotransduction between bone cells [PDF]

open access: yes, 2009
Mechanical forces are known to regulate the function of tissues in the body, including bone. Bone adapts to its mechanical environment by altering its shape and increasing its size in response to increases in mechanical load associated with exercise, and
Komarova, S. V.   +4 more
core  

General analysis of mathematical models for bone remodeling

open access: yes, 2010
Bone remodeling is regulated by pathways controlling the interplay of osteoblasts and osteoclasts. In this work, we apply the method of generalized modelling to systematically analyse a large class of models of bone remodeling.
Gross, Thilo   +3 more
core   +1 more source

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

open access: yesAdvanced Healthcare Materials, EarlyView.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo   +3 more
wiley   +1 more source

Osteogenic Differentiation of Human Gingival Fibroblasts Inhibits Osteoclast Formation

open access: yesCells
Gingival fibroblasts (GFs) can differentiate into osteoblast-like cells and induce osteoclast precursors to differentiate into osteoclasts. As it is unclear whether these two processes influence each other, we investigated how osteogenic differentiation ...
Merve Ceylan   +7 more
doaj   +1 more source

Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration

open access: yesAdvanced Healthcare Materials, EarlyView.
Hybrid wrinkled topographies coordinate immune, tissue, and bacterial interactions. The surfaces promote osteointegration, tune macrophage polarization, and inhibit biofilm formation, highlighting a multifunctional strategy for next‐generation implant design.
Mohammad Asadi Tokmedash   +4 more
wiley   +1 more source

Preparation of Bifunctional Orthosilicophosphate MgO‐CaO‐ZnO‐P2O5‐SiO2 Glasses: in vitro Evaluation of Antibacterial Activity and Osteoblast Gene Expression Behavior

open access: yesAdvanced Healthcare Materials, EarlyView.
Bifunctional ZnO‐containing orthosilicophosphate glasses (SPGs) composed mainly of orthotetrahedral groups with the unique glass network structure without long‐chain units are prepared via melt‐quenching. The glasses exhibit excellent antibacterial activity and upregulate the expression of osteogenic markers by releasing inorganic ions.
Sungho Lee   +4 more
wiley   +1 more source

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