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Osteoclasts and Integrins [PDF]
Annals of the New York Academy of Sciences, 2006 Abstract: The osteoclast is the unique bone resorptive cell that accomplishes its mission by forming an isolated acidified microenvironment between itself and the bone surface. Creation of this compartment is the first step in bone degradation and establishes that an intimate physical relationship must exist between the osteoclast and bone.
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Annals of the New York Academy of Sciences, 2010
Thirty‐five years ago it had become clear that the osteoclast was not a bone cell but an immigrant into bone, derived from the hemopoietic system. Among hemopoietic cells, mononuclear phagocytes seemed the most likely precursors. However, for the progeny of wandering cells such as those to achieve nonrandom localization implies control by the local ...
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Thirty‐five years ago it had become clear that the osteoclast was not a bone cell but an immigrant into bone, derived from the hemopoietic system. Among hemopoietic cells, mononuclear phagocytes seemed the most likely precursors. However, for the progeny of wandering cells such as those to achieve nonrandom localization implies control by the local ...
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Multinuclearity of Osteoclasts
Nature, 1963THE origin and function of the multinuclear osteoclast cell are of continuing interest among contemporary investigators, and have a long history among investigations on amphibian regeneration1,2.
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Generation of Osteoclasts In Vitro, and Assay of Osteoclast Activity
2007Osteoclasts are bone-resorbing multinucleated cells derived from the monocyte-macrophage lineage. The authors have developed a mouse marrow culture system and a coculture system of mouse osteoblasts and hemopoietic cells, in which osteoclasts are formed in response to various osteotropic factors such as 1alpha,25-dihydroxyvitamin D3, parathyroid ...
Nobuyuki Udagawa +3 more
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The osteoclast and periodontitis
Journal of Clinical Periodontology, 1986Abstract. The osteoclast may play an important rô le in the variable rate of osseous destruction seen in periodontitis. Current understanding of various aspects of the osteoclast may help explain this fact. This review paper will first look at two theories of cell origin of the osteoclast: the multipotential osteoprogenitor cell theory and the ...
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Long bone osteoclasts display an augmented osteoclast phenotype compared to calvarial osteoclasts
Biochemical and Biophysical Research Communications, 2010Osteoclasts are multinucleated cells specialized in degrading bone and characterized by high expression of the enzymes tartrate-resistant acid phosphatase (TRAP) and cathepsin K (CtsK). Recent studies show that osteoclasts exhibit phenotypic differences depending on their anatomical site of action.
Göran Andersson +2 more
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1998
Publisher Summary This chapter discusses the osteoclast cytoskeleton. Eukaryotic cells contain three major classes of cytoskeletal fibers: 7 nm diameter actin microfilaments, 24 nm diamenter microtubules (MTs), and 10 nm diameter intermediate filaments. All of these fibers are formed by finely regulated polymerization of protein subunits.
ZAMBONIN ZALLONE A +2 more
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Publisher Summary This chapter discusses the osteoclast cytoskeleton. Eukaryotic cells contain three major classes of cytoskeletal fibers: 7 nm diameter actin microfilaments, 24 nm diamenter microtubules (MTs), and 10 nm diameter intermediate filaments. All of these fibers are formed by finely regulated polymerization of protein subunits.
ZAMBONIN ZALLONE A +2 more
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Osteoblasts and Osteoclasts [PDF]
, 2000 The skeleton is a highly specialized and dynamic organ that undergoes continuous regeneration. Its functions are to maintain the shape of the body, protect vital organs, serve as a scaffold for the muscles, allowing their contractions to be translated into bodily movements, resist mechanical load during locomotion and weight bearing, and provide a ...
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Microscopy Research and Technique, 2003
AbstractOsteoclasts are the only cells capable of resorbing mineralised bone, dentine and cartilage. Osteoclasts act in close concert with bone forming osteoblasts to model the skeleton during embryogenesis and to remodel it during later life. A number of inherited human conditions are known that are primarily caused by a defect in osteoclasts. Most of
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AbstractOsteoclasts are the only cells capable of resorbing mineralised bone, dentine and cartilage. Osteoclasts act in close concert with bone forming osteoblasts to model the skeleton during embryogenesis and to remodel it during later life. A number of inherited human conditions are known that are primarily caused by a defect in osteoclasts. Most of
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Isolation and Generation of Osteoclasts
2019This chapter describes the isolation, culture, and staining of osteoclasts. The key advantages of this assay are that it allows direct measurement of osteoclast number, bone resorption, as well as yielding good quantities of osteoclasts at defined stages of formation for molecular analysis.
Nadia Rucci, Alberta Zallone, Anna Teti
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