Results 201 to 210 of about 130,158 (334)

Study on the Screening of Anti‐Osteoporosis Components in Processed Epimedium‐Based on Spectrum‐Effect Analysis

Chemistry &Biodiversity, EarlyView.
ABSTRACT Epimedium (EP) is a traditional Chinese medicine that has been used to treat osteoporosis for several years, but its mechanism of action is unclear. We used ultrahigh‐performance liquid chromatography coupled with triple–quadrupole mass spectrometry (UPLC–QQQ–MS/MS) to detect the components of raw and processed EP samples.
Jinling Liang, Jia Liu, Weixia Sun, Pan Li, Huaizhu Sun, Wenxuan Cao, Yulin Dai, Tianyang Xu, Peng Yu   +8 more
wiley   +1 more source

Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis. [PDF]

Nat Commun
Ma Q, Wang S, Xue H, Ni L, Yuan P, Shen Y, Zheng B, Wang Q, Zhang J, Wang H, Xie H, Jiang C, Qin A, Fan S, Xie Z, Jie Z.   +15 more
europepmc   +1 more source

Effect of colchicine on the Golgi apparatus and the lysosmal system in osteoclasts.

, 1990
Toshihiro Oda
openalex   +2 more sources

Identification of Human Asparaginyl Endopeptidase (Legumain) as an Inhibitor of Osteoclast Formation and Bone Resorption [PDF]

, 1999
Sun Jin Choi, Sakamuri V. Reddy, Rowena D. Devlin, Cheikh Menaa, Ho-Yeon Chung, Brendan F. Boyce, G. David Roodman   +6 more
openalex   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

Activation of AKT1 enhances the capacity of senescent BMSCs to regulate osteoclast activation. [PDF]

Mol Med Rep
Lu C, Peng X, Zhang B, Yan Q, Dou B, Karanis G, Gu W, Karanis P, Li K.   +8 more
europepmc   +1 more source

Osteopontin Expression by Osteoclast and Osteoblast Progenitors in the Murine Bone Marrow: Demonstration of Its Requirement for Osteoclastogenesis and Its Increase After Ovariectomy* [PDF]

, 1997
Tomoo Yamate, Hanna Mocharla, Yasuto Taguchi, Joseph U. Igietseme, Stavros C. Manolagas, Etsuko Abe   +5 more
openalex   +1 more source

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source

Adjuvant pharmacological strategies for the musculoskeletal system during long‐term space missions

British Journal of Clinical Pharmacology, EarlyView., 2023
Abstract Despite 2 h of daily exercise training, muscle wasting and bone loss are still present after 6‐month missions to the international space station. Some crew members lose bone much faster than others. In preparation for missions to the Moon and Mars, space agencies are therefore reviewing their countermeasure portfolios.
Friederike Thomasius, Dominik Pesta, Jörn Rittweger   +2 more
wiley   +1 more source

The unexplored relationship between spontaneous osteoclastogenesis and platelets in osteoporosis. [PDF]

Front Med (Lausanne)
Salamanna F, Di Martino A, Contartese D, Faldini C, Giavaresi G, Fini M.   +5 more
europepmc   +1 more source