Results 121 to 130 of about 132,467 (326)

Odontogenic Cysts of upper jaw an analysis [PDF]

, 2013
This article attempts to analyze all cases of odontogenic cysts involving upper jaw who presented at Stanley Medical college during 2007 – 2012. This article analyzes the incidence of these cystsduring the above said period, age of occurence, sex ...
Ramamoorthy, Geetha, Thiagarajan, Balasubramanian   +1 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Toll-like receptor-2 induced inflammation causes local bone formation and activates canonical Wnt signaling

Frontiers in Immunology
It is well established that inflammatory processes in the vicinity of bone often induce osteoclast formation and bone resorption. Effects of inflammatory processes on bone formation are less studied.
Petra Henning, Ali Kassem, Anna Westerlund, Pernilla Lundberg, Cecilia Engdahl, Cecilia Engdahl, Vikte Lionikaite, Pernilla Wikström, Jianyao Wu, Lei Li, Catharina Lindholm, Catharina Lindholm, Pedro P. C. de Souza, Sofia Movérare-Skrtic, Ulf H. Lerner, Ulf H. Lerner   +15 more
doaj   +1 more source

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

Caffeine regulates both osteoclast and osteoblast differentiation via the AKT, NF-κB, and MAPK pathways

Frontiers in Pharmacology
Background: Although caffeine generally offers benefits to human health, its impact on bone metabolism remains unclear.Aim and Methods: This study aimed to systematically evaluate the long-term effects of caffeine administration on osteoclasts ...
Yue Miao, Yue Miao, Lei Zhao, Shuwen Lei, Chunyan Zhao, Qiuping Wang, Chao Tan, Chunxiu Peng, Jiashun Gong, Jiashun Gong   +9 more
doaj   +1 more source

Author response for "Sexual dimorphism in differentiating osteoclast precursors demonstrates enhanced inflammatory pathway activation in female cells"

, 2021
Se Hwan Mun, Sandra Jastrzebski, Judy Kalinowski, Steven L. Zeng, Brian Oh, Seyeon Bae, Giannopoulou Eugenia, Nazir M. Khan, Hicham Drissi, Ping Zhou, Bongjin Shin, Sun‐Kyeong Lee, Joseph Lorenzo, Kyung‐Hyun Park‐Min   +13 more
openalex   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts

, 2021
Jiaxin Guan, Lu Gan, Di Jin, Xiaowei Wu, Luyang Cheng, Meiling Liu, Ying Fan, Jing Zhou, Hanlu Zhang, Yina Zhang, Ping Zhou   +10 more
openalex   +1 more source

Mediators of mechanotransduction between bone cells [PDF]

, 2009
Mechanical forces are known to regulate the function of tissues in the body, including bone. Bone adapts to its mechanical environment by altering its shape and increasing its size in response to increases in mechanical load associated with exercise, and
Komarova, S. V., Lopez, M., Miura, R. M., Qazi, S., Wall, D. J. N.   +4 more
core  

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source