Results 131 to 140 of about 109,289 (351)

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source

Multiple verification in computational modeling of bone pathologies

, 2011
We introduce a model checking approach to diagnose the emerging of bone pathologies. The implementation of a new model of bone remodeling in PRISM has led to an interesting characterization of osteoporosis as a defective bone remodeling dynamics with ...
A. Aziz, D.T. Gillespie, E. Bartocci, E. Bartocci, E. Bartocci, Emanuela Merelli, Erik de Vink, G. Karsenty, Ion Petre, L.J. Raggatt, M. Calder, M. Kwiatkowska, M. Kwiatkowska, N. Paoletti, Nicola Paoletti, P. Lió, Pietro Liò, R. Barbuti, R. Hanada, S. Jabbar, S.C. Manolagas, T.E. Pronk   +21 more
core   +2 more sources

Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3in vivo [PDF]

, 2002
Background Although much is known about the regulation of osteoclast (OC) formation and activity, little is known about OC senescence. In particular, the fate of of OC seen after 1,25-(OH)2D3 administration in vivo is unclear.
A Jäger, A Kahn, B Riggs, C Dijkstra, D Fischman, D Hughes, F Solari, G Hattersley, G Hattersley, G Roodman, G Vaes, H Uy, I McLean, J Bollerslev, J Feyen, J Gram, J Merke, J Owens, J Zerwekh, JC Gallagher, JG Damoiseaux, JJ Reynolds, M Holtrop, N Athanasou, N Udagawa, P Bianco, P Geusens, P Hauschka, P McSheehy, R Beelen, R Boyce, R Felix, R Felix, R Kitazawa, RG Erben, S Manolagas, S Marks, S Mori, S Ott, S Tinkler, T Murakami, T Sminia, T Suda, T Suda, W Bourque, Y Kobayashi, Y Tanaka   +46 more
core   +4 more sources

The cellular dynamics of bone remodeling: a mathematical model [PDF]

SIAM J. Appl. Math. 70, pp. 1899-1921, 2011
The mechanical properties of vertebrate bone are largely determined by a process which involves the complex interplay of three different cell types. This process is called {\it bone remodeling}, and occurs asynchronously at multiple sites in the mature skeleton.
arxiv  

Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts.

Journal of Clinical Investigation, 2000
Osteoclasts express the alphavbeta3 integrin, an adhesion receptor that has been implicated in bone resorption and that is therefore a potential therapeutic target.
K. Mchugh, K. Hodivala-Dilke, M. Zheng, N. Namba, Jonathan D. Lam, D. Novack, Xunqiang Feng, F. Ross, R. Hynes, S. Teitelbaum   +9 more
semanticscholar   +1 more source

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

Advanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng   +12 more
wiley   +1 more source

Single‐Cell Analysis Clarifies Pathological Heterogeneity in Tenosynovial Giant Cell Tumor and Identifies Biomarkers for Predicting Disease Recurrence

Advanced Science, EarlyView.
MP3 tumor cells, a specific subpopulation of tumor cells in D‐TGCT, regulated the differentiation of CD34+ Fbs into MMP3+ Fbs and APOE+ Fbs through COL6A3 − (ITGAV + ITGB8) interaction. APOE+ Fbs activated IL‐1B+CCL20+ Mφs through the CXCL12/CXCR4 axis. IL‐1B+CCL20+ Mφs and MMP3+ Fbs participated in the local invasion of D‐TGCT.
Yubin Xie, Chen Chen, Fei Wu, Yiman Peng, Jing Su, Yang Zhao, Hongjie Huang, Zhong Alan Li, Yin Pei, Wencui Li, Yi He, Tianchen Xue, Chenxi Cao, Sui Peng, Xin Zhang, Weidong Song   +15 more
wiley   +1 more source

The Role of Substance P in the Regulation of Bone and Cartilage Metabolic Activity

Frontiers in Endocrinology, 2020
Substance P (SP) is a neuropeptide that is released from sensory nerve endings and is widely present in nerve fibers. It acts on bones and related tissues by binding to receptors, thereby regulating bone metabolism, cartilage metabolism, and fracture ...
Fu-Xing-Zi Li, Feng Xu, Xiao Lin, Feng Wu, Jia-Yu Zhong, Yi Wang, Bei Guo, Ming-Hui Zheng, Su-Kang Shan, Ling-Qing Yuan   +9 more
doaj   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

A novel method to efficiently differentiate human osteoclasts from blood-derived monocytes

Biological Procedures Online
Background Osteoclasts are the tissue-specific macrophage population of the bone and unique in their bone-resorbing activity. Hence, they are fundamental for bone physiology in health and disease.
Suganja Chandrabalan, Linh Dang, Uwe Hansen, Melanie Timmen, Corinna Wehmeyer, Richard Stange, Tim Beißbarth, Claudia Binder, Annalen Bleckmann, Kerstin Menck   +9 more
doaj   +1 more source