Results 161 to 170 of about 109,289 (351)

On the occurrence in vitro of cells resembling osteoclasts [PDF]

, 1946
N. M. Hancox
openalex   +1 more source

Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts (*)

Journal of Biological Chemistry, 1996
Random high throughput sequencing of a human osteoclast cDNA library was employed to identify novel osteoclast-expressed genes. Of the 5475 ESTs obtained, approximately 4% encoded cathepsin K, a novel cysteine protease homologous to cathepsins S and L ...
F. Drake, R. Dodds, I. James, J. Connor, C. Debouck, S. Richardson, E. Lee-Rykaczewski, Lindsay Coleman, D. Rieman, Ray Barthlow, G. Hastings, M. Gowen   +11 more
semanticscholar   +1 more source

Single‐Cell Analysis Reveals that Vitamin C Inhibits Bone Metastasis of Renal Cancer via Cell Cycle Arrest and Microenvironment Remodeling

Advanced Science, EarlyView.
3D‐cultured renal cancer cells exhibit stem‐like phenotypes and are more efficient in generating bone metastases. Vitamin C treatment can suppress the development of bone metastasis. Single‐cell transcriptomic analysis reveals that vitamin C inhibits metastasis by inducing tumor cell cycle arrest, suppressing osteoclast differentiation, and reducing ...
Jianye Zhang, Qi Zhang, Gang Lin, Ying Wang, Juan Li, Ping Wang, Jie Qi, Yuan Liang, Shiming He, Yanqing Gong, Ninghan Feng, Yang Wang, Yuanyuan Ma, Mei Zhang, Yue Shi, Xuesong Li, Weimin Ci, Liqun Zhou   +17 more
wiley   +1 more source

Novel Nanohydroxyapatite (nHAp)-Based Scaffold Doped with Iron Oxide Nanoparticles (IO), Functionalized with Small Non-Coding RNA (miR-21/124) Modulates Expression of Runt-Related Transcriptional Factor 2 and Osteopontin, Promoting Regeneration of Osteoporotic Bone in Bilateral Cranial Defects in a Senescence-Accelerated Mouse Model (SAM/P6). PART 2

International Journal of Nanomedicine, 2021
Krzysztof Marycz,1,2 Agnieszka Śmieszek,1 Katarzyna Kornicka-Garbowska,1,2 Ariadna Pielok,1 Maciej Janeczek,3 Anna Lipińska,3 Anna Nikodem,4 Jarosław Filipiak,4 Paulina Sobierajska,5 Jean-Marie Nedelec,6 Rafał J Wiglusz2,5 ...
Marycz K, Śmieszek A, Kornicka-Garbowska K, Pielok A, Janeczek M, Lipińska A, Nikodem A, Filipiak J, Sobierajska P, Nedelec JM, Wiglusz RJ   +10 more
doaj  

Updates on Osteoimmunology: What's New on the Cross-Talk Between Bone and Immune System

Frontiers in Endocrinology, 2019
The term osteoimmunology was coined many years ago to describe the research field that deals with the cross-regulation between bone cells and the immune system.
Marco Ponzetti, Nadia Rucci
doaj   +1 more source

Population stability risks and biophysical benefits of cell-cell fusion in macrophage, osteoclast, and giant multinucleated cells [PDF]

arXiv, 2019
Plant and animal cells are commonly understood as acquiring specialized functions through differentiation and asymmetric division. However, unique capabilities are also acquired when two or more cells fuse together, mixing cytoplasmic and genetic material.
arxiv  

Effect of medium pH on osteoclast activity and osteoclast formation in cultures of dispersed rabbit osteoclasts

Journal of Bone and Mineral Research, 1993
Abstract We investigated the effect of medium pH on activity of isolated osteoclasts and have also looked at the possibility that medium pH affects osteoclast numbers during culture. Osteoclast-containing cell suspensions prepared from neonatal rabbits were cultured on bovine bone slices at pH 6.5, 7.0, or 7.5.
Toshiaki Shibutani, J. N. M. Heersche
openaire   +2 more sources

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

Advanced Science, EarlyView.
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang, Heng Sun, Haojie Chen, Xiangpeng Wang, Junduo Zhao, Yang Jiao, Hongyi Zhou, Haoyu Cai, Jiafeng Dai, Xuan Huang, Weiyun Chen, Jianxiong Shen   +11 more
wiley   +1 more source

Effects of hydroxyapatite gypsum puger scaffold applied to rat alveolar bone sockets on osteoclasts, osteoblasts and the trabecular bone area

Dental Journal, 2019
Background: Damage to bone tissue resulting from tooth extraction will cause alveolar bone resorption. Therefore, a material for preserving alveolar sockets capable of maintaining bone is required.
Amiyatun Naini, I Ketut Sudiana, Mohammad Rubianto, Utari Kresnoadi, Faurier Dzar Eljabbar Latief   +4 more
doaj   +1 more source

Rapid activation of the medullary bone osteoclast cell surface by parathyroid hormone. [PDF]

, 1978
Scott C. Miller
openalex   +1 more source