Results 161 to 170 of about 111,801 (276)

Osteoclast [PDF]

, 2020
openaire   +1 more source

PSMA‐Targeting Macrophage Membrane‐Coated Nanoparticles for Precision Diagnosis and Combination Therapy of Prostate Cancer

Exploration, EarlyView.
Advanced prostate cancer is highly invasive and prone to rapid metastasis, creating an urgent need for novel therapeutic strategies. We developed a PSMA‐targeting macrophage membrane‐coated nanomedicine (P‐MMCNPs@DM1). Leveraging the immune‐evasive and active‐targeting properties of macrophage membrane coating, P‐MMCNPs@DM1 effectively managed both ...
Keying Zhang, Bo Gao, Jingwei Wang, Yu Li, Chao Xu, Fa Yang, Shaojie Liu, Hongji Li, Chao Zhang, Xiangliang Meng, Zhaokun Shi, Rui Zhang, Ruili Zhang, Zhongliang Wang, Weihong Wen, Qiang Zhang, Yuankang Zou, Donghui Han, Huijie Bian, Weijun Qin   +19 more
wiley   +1 more source

Selective disruption of microtubule formation at the nuclear envelope impairs the bone resorption capacity of osteoclasts. [PDF]

J Cell Sci
Vergarajauregui S, Panea S, Oltmanns JO, Steffen U, Engel FB.   +4 more
europepmc   +1 more source

Ultrasmall Au10–12 Nanoclusters: A Novel Platform for 223Ra‐Targeted Tumor α‐Therapy

Exploration, EarlyView.
Encapsulating 223Ra in Au10‐12 nanoclusters and functionalizing them with RGD peptides enables targeted α‐therapy and immune microenvironment remodeling in non‐osseous tumors like triple‐negative breast cancer. This study establishes a foundational framework for novel 223Ra‐labeled α‐radiopharmaceuticals and shows strong potential for clinical ...
Yifei Jiang, Huizhen Yang, Guoping Jia, Wangxi Hai, Rongyi Huang, Peng Wang, Min Zhang, Danni Li, Yizhou Chen, Xiao Li, Biao Li, Chunfu Zhang   +11 more
wiley   +1 more source

An alkaline nanosized platelet vesicle-based hydrogel for the treatment of osteoporotic bone defects. [PDF]

Mater Today Bio
Yang K, Yang Y, Xia C, Chen Y, Dai Z, Wang Z, Hu L, Li Y, Wang Y, Wang Y, Li W, Wang Q, Li N, Jiang S, Zu S, Hao F, Shen Q, Fan S, Chen P, Shangguan L, Ning L.   +20 more
europepmc   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Plant‐derived extracellular vesicle‐like particles as novel osteoanabolic agents: Activating bone morphogenetic protein 2/Smads signaling axis for bone regeneration in postmenopausal osteoporosis

Interdisciplinary Medicine, EarlyView.
Illustration depicting the isolation of Dipsaci Radix derived extracellular vesicle‐like particles and their function in alleviating osteoporosis. (A) Extraction and characterization detection process of extracellular vesicle‐like particles derived from Dipsaci Radix roots. (B) Cell experiments in vitro, Dipsaci Radix derived extracellular vesicle‐like
Qing Zhao, Yue Cao, Zhengting Wu, Yingqi Cao, Qi You, Yuanyuan Xia, Xuejun Tan, Dongxiao Li, Tianxin Qiu, Xiuping Cai, Zhaodi Guo, Lei Zheng, Kewei Zhao   +12 more
wiley   +1 more source

Vildagliptin and Omarigliptin Differentially Bind to DPP-4 Homodimers and Modulate Osteoclast-Mediated Bone Resorption. [PDF]

Compr Physiol
Aeimlapa R, Panmanee J, Teerapornpuntakit J, Wongdee K, Thongbunchoo J, Panupinthu N, Svasti S, Apaijai N, Sa-Nguanmoo P, Chattipakorn S, Chattipakorn N, Charoenphandhu N.   +11 more
europepmc   +1 more source

Biofilm removal capacity and titanium surface integrity in non‐abrasive versus abrasive peri‐implantitis cleaning interventions

Journal of Periodontology, EarlyView.
Abstract Background Current peri‐implantitis treatment methods are modeled after dental cleaning modalities like abrasive surface cleaning. However, mechanical abrasive cleaning not only inadequately removes implant biofilms but also compromises implant surface integrity with adverse biological effects.
Marzieh S. Jazaeri, Danyal A. Siddiqui, Yi‐Wen C. Tsai, Kathryn Gabel, Zachary Lorenzana, Georgios A. Kotsakis   +5 more
wiley   +1 more source

Nutrients and Metabolites as Signalling Molecules in Osteoclasts. [PDF]

Curr Osteoporos Rep
Chandrasekaran K, Hu S, Farstad-O'Halloran K, Iyer KS, Jiang H, Pavlos N, Chen K.   +6 more
europepmc   +1 more source