Results 171 to 180 of about 132,467 (326)

Osteoclast Formation within a Human Co-Culture System on Bone Material as an In Vitro Model for Bone Remodeling Processes [PDF]

, 2018
Franziska F.-F. Schmid, Claudia Kleinhans, Freia Schmid, Petra J. Kluger   +3 more
openalex   +1 more source

Various roles of heme oxygenase-1 in response of bone marrow macrophages to RANKL and in the early stage of osteoclastogenesis [PDF]

, 2018
Bukowska-Straková, Karolina, Dulak, Józef, Florczyk-Soluch, Urszula, Józefczuk, Ewelina, Józkowicz, Alicja, Mendel, Mateusz, Nowak, Witold, Stępniewski, Jacek, Viscardi, Monika   +8 more
core   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

Loss of myocyte enhancer factor 2 expression in osteoclasts leads to opposing skeletal phenotypes

, 2020
Nicholas Blixt, Andrew Norton, Anqi Zhang, Conrado Aparicio, Hari Prasad, Rajaram Gopalakrishnan, Eric D. Jensen, Kim C. Mansky   +7 more
openalex   +2 more sources

Osteoclast cell-surface changes during the egg-laying cycle in Japanese quail [PDF]

, 1977
Scott C. Miller
openalex   +1 more source

HTLV-1 viral oncogene HBZ induces osteolytic bone disease in transgenic mice [PDF]

, 2017
Esser, Alison K, et al,, Harding, John C, Ratner, Lee, Rauch, Daniel A, Ross, Michael H, Su, Xinming, Vij, Kiran, Weilbaecher, Katherine N, Wu, Kevin, Xiang, Jingyu, Xu, Yalin   +11 more
core   +2 more sources

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Essential role of macrophage colony-stimulating factor in the osteoclast differentiation supported by stromal cells. [PDF]

, 1991
Hiroaki Kodama, M Nose, Shumpei Niida, Akira Yamasaki   +3 more
openalex   +1 more source

Extramedullary Disease—Achilles Heel in Myeloma?

American Journal of Hematology, EarlyView.
ABSTRACT Despite advances in therapy, extramedullary disease (EMD) remains an aggressive form of multiple myeloma associated with poor outcomes. Patients with true EMD, in which plasmacytomas have become completely independent of bone, have a particularly poor prognosis. The pathogenesis of EMD is driven by complex mechanisms involving loss of adhesion
Shaji Kumar, Joshua Richter, Saad Z. Usmani, Yael C. Cohen, Jing Christine Ye, María‐Victoria Mateos, Vania Hungria, Elena Zamagni   +7 more
wiley   +1 more source

Vildagliptin and Omarigliptin Differentially Bind to DPP-4 Homodimers and Modulate Osteoclast-Mediated Bone Resorption. [PDF]

Compr Physiol
Aeimlapa R, Panmanee J, Teerapornpuntakit J, Wongdee K, Thongbunchoo J, Panupinthu N, Svasti S, Apaijai N, Sa-Nguanmoo P, Chattipakorn S, Chattipakorn N, Charoenphandhu N.   +11 more
europepmc   +1 more source