Results 181 to 190 of about 132,467 (326)

Establishment of a biosafe murine model of skeletal tuberculosis using Mycobacterium smegmatis

Animal Models and Experimental Medicine, EarlyView.
This study developed a biosafe, accessible, and versatile murine model of bone TB using Mycobacterium smegmatis, a fast‐growing, nonpathogenic mycobacterial species with high genomic homology to Mycobacterium tuberculosis. Three infection routes—subperiosteal calvarial injection, intratibial injection, and intracardiac (left ventricular) inoculation ...
Yewei Jia, Yuhuai Guo, Yusheng Yang, Jie Zhang, Ziyang Zhang, Ying Qu, Jiulin Tan, Jie Shen, Nathachit Limjunyawong, Jianzhong Xu, Zehua Zhang, Fei Luo, Ce Dou   +12 more
wiley   +1 more source

Cell signaling and transcriptional regulation of osteoclast lineage commitment, differentiation, bone resorption and diseases. [PDF]

Cell Discov
Zhu S, Yan MQ, Masson A, Chen W, Li YP.
europepmc   +1 more source

An in vivo assay for osteoclast activity using mouse calvaria

Animal Models and Experimental Medicine, EarlyView.
This study describes a novel method for measuring osteoclast‐mediated bone resorption in vivo using a mouse model. Localized injection of RANKL in a basement membrane matrix above the cranium induced osteoclast‐mediated bone resorption. Utilizing micro‐computed tomography and a semiautomated three‐dimensional analysis program, osteoclast resorption pit
Christopher Grieg, Maya Deza Culbertson, J. Patrick O'Connor   +2 more
wiley   +1 more source

Fibroblast-derived NEU1 as a therapeutic target for improving cortical bone integrity and fracture healing. [PDF]

Theranostics
Wu Y, Ai H, Zhang C, Qu Y, Tan J, Limjunyawong N, Xu J, Dong S, Luo F, Dou C.   +9 more
europepmc   +1 more source

PEG-rHuMGDF Causes Osteogenesis by Stimulating Osteoblast Differentiation and Inhibiting Osteoclast Differentiation in Normal Mice.

, 2001
Youichi Ide, Eri Yamanaka, Yasuko Namiki, Yasuko Kikuchi, Hiromi Ishii, Jun‐ichi Kawahara, Kunio Doi   +6 more
openalex   +2 more sources

Engineering Ultrasound Contrast Agents for Targeted Therapeutics: A Theranostic Approach to Drug Delivery, Gene Therapy, and Immunomodulation

Advanced NanoBiomed Research, EarlyView.
Ultrasound contrast agents, including microbubbles and nanobubbles, transform imaging and targeted therapy through precise engineering of size, shell composition, and surface properties. This review explores how these innovations enable tissue‐specific delivery, enhance therapeutic efficacy, and extend applications from vascular imaging to tumor ...
Ashkan Seza, Kimia Mozahheb Yousefi, Sara Minaeian   +2 more
wiley   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

C-X-C motif chemokine ligand 13 suppresses osteoclast differentiation via interference with RANKL-RANK interaction. [PDF]

Front Immunol
Ho TL, Lee KT, He YH, Thuong LHH, Achudhan D, Huang WC, Ko CY, Liu CL, Guo JH, Tang CH.   +9 more
europepmc   +1 more source

Bergapten prevents lipopolysaccharide mediated osteoclast formation, bone resorption and osteoclast survival

, 2013
Mingxia Zheng, Yongliang Ge, Haiyu Li, Ming Yan, Jin Zhou, Yun Zhang   +5 more
openalex   +2 more sources

Role of soft tissue and bone interactions in the developmental integration and modularity of the skull in neural crest‐specific gap junction alpha‐1 knockout mice

The Anatomical Record, EarlyView.
Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore, Madeline Tourigny, Diana Quinonez, Kevin Barr, Matthew W. Grol, Katherine E. Willmore   +5 more
wiley   +1 more source