Results 261 to 270 of about 132,120 (348)

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

Cell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao, Yifan Xu, Haoran Du, Zixiao Li, Xiaochen Fang, Minghui Wang, Jia Liu, Xu Zha, Xianglong Han, Weihua Guo, Xicheng Liu, Jian Zhou   +11 more
wiley   +1 more source

MSDC-0160, a novel clinical-stage mitochondrial pyruvate carrier inhibitor, suppresses osteoclast differentiation and alleviates type 2 diabetes-related bone loss. [PDF]

J Transl Med
Wang C, Hai N, Chen L, Huang Q, Gui Y, Su Y, Lian H, Liang J, Zhao J, Xu J, Liu Q.   +10 more
europepmc   +1 more source

TACE-Mediated Shedding Supports a Role for Semaphorin 4D Expressed on Osteoclasts in Up-Regulation of RANKL-Induced Osteoclastogenesis

, 2017
Jae‐Young Kim
openalex   +1 more source

Inhibition of Fibroblast Activation Protein‐α Ameliorates Intervertebral Disc Degeneration via Reduced Vascular Invasion in Cartilage Endplate

Cell Proliferation, EarlyView.
Schematic illustration showing that FAP‐α promoted angiogenesis, cytokine release and ECM degradation in the CEP degeneration of the intervertebral disc through upregulating the PI3K/Akt/HIF‐1α/VEGFA pathway. ABSTRACT Intervertebral disc degeneration (IDD) is a primary cause of low back pain, with the development of new blood vessels being a key ...
Hao‐Wei Xu, Sheng‐Jie Chang, Shuo Wang, Xiao‐Wei Liu, Shan‐Jin Wang   +4 more
wiley   +1 more source

Constitutive activation of TGF-β receptor type I promotes cortical and cancellous bone formation in adult mice. [PDF]

PLoS One
Chotipinit T, Toejing P, Phetkong C, Sridurongrit S, Leelahavanichkul A, Charles JF, Lotinun S.   +6 more
europepmc   +1 more source

The role of purinergic signalling in the musculoskeletal system [PDF]

Abbracchio, Agrawal, Alvarenga, Armstrong, Banachewicz, Berenbaum, Biswas, Biver, Bonewald, Bowler, Bowler, Bowler, Brandao-Burch, Brown, Buckley, Buckley, Buckley, Bulman, Burnstock, Burnstock, Burnstock, Burnstock, Buscher, Buvinic, Campo, Carroll, Caswell, Caswell, Chenu, Cheung, Choi, Chowdhury, Costa, Costessi, Croucher, Deli, Dixon, Evans, Ferrari, Fleisch, Fleisch, Fodor, Gartland, Gartland, Gartland, Gartland, Gartland, Genetos, Genetos, Gharibi, Gharibi, Graff, Graff, Grol, Hajjawi, Hayton, Hazama, He, Hecht, Hessle, Hiken, Hoebertz, Hoebertz, Hoebertz, Hollopeter, Hsu, Hung, Huo, Husted, Ihara, Isabel R. Orriss, Jande, Janssens, Janssens, Johnson, Jones, Jorgensen, Jorgensen, Jorgensen, Kanabe, Kaplan, Kaplan, Kara, Kara, Katz, Katz, Ke, Keresztes, Knight, Kono, Koolpe, Koolpe, Korcok, Korcok, Kringelbach, Kudirka, Kumagai, Kumagai, Lee, Leong, Leong, Lerner, Lerner, Li, Li, Liu, Mackenzie, Martinello, Masin, Mediero, Mediero, Meyer, Millward-Sadler, Morrison, Mortensen, Naemsch, Naemsch, Nakamura, Nicke, Nishii, Noronha-Matos, Noronha-Matos, Ohlendorff, Orriss, Orriss, Orriss, Orriss, Orriss, Orriss, Orriss, Orriss, Orriss, Panupinthu, Panupinthu, Pellegatti, Penolazzi, Pines, Ralevic, Reimer, Riddle, Romanello, Romanello, Rosenthal, Rumney, Ryan, Ryten, Schoenberg, Sciancalepore, Shimegi, Sistare, Su, Suzuki, Syberg, Syberg, Takedachi, Tesch, Thompson, Tu, Varani, Varani, Vincenzi, Voss, Wang, Wang, Wang, Weidema, Weidema, Wesselius, Wesselius, Wesselius, Wiebe, Wildman, You, Yu, Yu, Zimmermann, Zippel   +176 more
core   +1 more source

Hypoxia Promotes Osteoclast Differentiation through Weakening the USP18-Mediated Suppression on NF-κB Signaling Pathway

Xiaoxia Fan, Botong Li, Shengjun Chai, Rong Zhang, Chunmei Cai, Ri‐Li Ge   +5 more
openalex   +2 more sources

Unexpected Promotion of Bone Regeneration by Inhibition of BMPR1A‐Mediated BMP Signalling

Cell Proliferation, EarlyView.
BMPR1A downregulation reduces ID1, releases TCF3 to activate GNG4‐PI3K‐AKT signalling, thereby promoting OPC proliferation and bone regeneration. ABSTRACT Bone morphogenetic protein (BMP) signalling plays a pivotal role in bone regeneration by regulating osteoprogenitor cell (OPC) function, and BMPs have been widely used in clinical treatment. However,
Zihao Zhou, Yun Zhai, Xiaochen Liu, Jiaojiao Shao, Jiani Zhou, Zhaoyang Li, Jiale He, Shuxian Lin, Qi Zhang   +8 more
wiley   +1 more source

CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis

Cell Proliferation, EarlyView.
CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng, Dihao Tao, Wenzhe Wang, Huiyu Wang, Hanzhe Wang, Yufan Liang, Jia Guo, Wenhao Liu, Yiming Wang, Jianhua Yang, Xiaoning He, Ce Shan, Bei Li   +12 more
wiley   +1 more source

Associations of Semaglutide With Skeletal Outcomes in People With Obesity, With and Without Type 2 Diabetes: A Target Trial Emulation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To evaluate the associations between semaglutide initiation and long‐term skeletal outcomes in people with obesity, stratified by type 2 diabetes (T2D) status, using target trial emulation. Materials and Methods This retrospective cohort study used the TriNetX federated electronic health record network.
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Shao‐Chia Chen, Hao‐I Hsieh, Gideon Meyerowitz‐Katz, Yen‐Liang Liu, Pen‐Hua Su   +8 more
wiley   +1 more source