Results 1 to 10 of about 31,027 (248)
Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis
Bone Research, 2022 Diabetic osteoporosis (DOP) is the leading complication continuously threatening the bone health of patients with diabetes. A key pathogenic factor in DOP is loss of osteocyte viability. However, the mechanism of osteocyte death remains unclear. Here, we
Yiqi Yang, Zhifeng Yu, Shengbing Yang
exaly +3 more sources
Neuronal Induction of Bone‐Fat Imbalance through Osteocyte Neuropeptide Y
Advanced Science, 2021 A differentiation switch of bone marrow mesenchymal stem/stromal cells (BMSCs) from osteoblasts to adipocytes contributes to age‐ and menopause‐associated bone loss and marrow adiposity.
Chun-Yuan Chen, Yi-Wei Liu, Kun Xia
exaly +3 more sources
Molecular Medicine, 2022 Background It is well-known that both macrophages and osteocytes are critical regulators of osteogenesis and osteoclastogenesis, yet there is limited understanding of the macrophage-osteocyte interaction, and how their crosstalk could affect bone ...
Shengfang Wang +5 more
doaj +2 more sources
Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin
Nature Communications, 2021 Some osteoblasts embed within bone matrix, change shape, and become dendrite-bearing osteocytes. The circuitry that drives dendrite formation during “osteocytogenesis” is poorly understood.
Courtney M Mazur +2 more
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Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption
International Journal of Molecular Sciences, 2020 The process of bone remodeling is the result of the regulated balance between bone cell populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the osteocyte, the mechanosensory cell type.
Hideki Kitaura +2 more
exaly +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Bone fragility increases with age as the result of the concurrent decline of bone mass, quality, and mechanosensitivity. While the coordinated decline of these behaviors remains unexplained, the role of osteocytes in each of these processes ...
Charles A Schurman +2 more
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Scientific Reports, 2021 Osteocytes are mechanosensory commander cells to regulate bone remodeling throughout the lifespan. While the osteocytes are known as terminally differentiated cells derived from mesenchymal stem cells, the detailed mechanisms of osteocyte differentiation
Jeonghyun Kim, Taiji Adachi
doaj +2 more sources
Osteocyte apoptosis: the roles and key molecular mechanisms in resorption-related bone diseases
Cell Death and Disease, 2020 Vital osteocytes have been well known to function as an important orchestrator in the preservation of robustness and fidelity of the bone remodeling process.
J. Ru, Yan-fen Wang
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Osteocyte β1 integrin loss causes low bone mass and impairs bone mechanotransduction in mice
Journal of Orthopaedic Translation, 2022 Background: The key focal adhesion protein β1 integrin plays an essential role in early skeletal development. However, roles of β1 integrin expression in osteocytes during the regulation of bone homeostasis and mechanotransduction are incompletely ...
Lei Qin +14 more
doaj +2 more sources
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction
Nature Communications, 2020 Osteocytes, cells ensconced within mineralized bone matrix, are the primary skeletal mechanosensors. Osteocytes sense mechanical cues by changes in fluid flow shear stress (FFSS) across their dendritic projections.
Murat Cetinbas +2 more
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