Results 91 to 100 of about 31,027 (248)

Osteocyte control of osteoclastogenesis [PDF]

Bone, 2013
Multiple lines of evidence support the idea that osteocytes act as mechanosensors in bone and that they control bone formation, in part, by expressing the Wnt antagonist sclerostin. However, the role of osteocytes in the control of bone resorption has been less clear. Recent studies have demonstrated that osteocytes are the major source of the cytokine
Charles A, O'Brien, Tomoki, Nakashima, Hiroshi, Takayanagi   +2 more
openaire   +2 more sources

A Novel Optimized Silver Nitrate Staining Method for Visualizing and Quantifying the Osteocyte Lacuno-Canalicular System (LCS)

Bio-Protocol
The osteocyte lacuno-canalicular system (LCS) plays a crucial role in maintaining bone homeostasis and mediating cellular mechanotransduction. Current histological techniques, particularly the Ploton silver nitrate staining method, face challenges such ...
Jinlian Wu, Chunchun Xue, Qiang Li, Hongjin Wu, Jie Zhang, Chenglong Wang, Weiwei Dai, Libo Wang   +7 more
doaj   +1 more source

PPARG in osteocytes controls cell bioenergetics and systemic energy metabolism independently of sclerostin levels in circulation

Molecular Metabolism
Objective: The skeleton is one of the largest organs in the body, wherein metabolism is integrated with systemic energy metabolism. However, the bioenergetic programming of osteocytes, the most abundant bone cells coordinating bone metabolism, is not ...
Sudipta Baroi, Piotr J. Czernik, Mohd Parvez Khan, Joshua Letson, Emily Crowe, Amit Chougule, Patrick R. Griffin, Clifford J. Rosen, Beata Lecka-Czernik   +8 more
doaj   +1 more source

Supplementary figure 2 from Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma

, 2023
Jesús Delgado‐Calle, Judith L. Anderson, Meloney Cregor, Masahiro Hiasa, John M. Chirgwin, Nadia Carlesso, Toshiyuki Yoneda, Khalid S. Mohammad, Lilian I. Plotkin, G. David Roodman, Teresita Bellido   +10 more
openalex   +1 more source

Phenotypic Characterization of Osteoarthritic Osteocytes from the Sclerotic Zones: A Possible Pathological Role in Subchondral Bone Sclerosis

International Journal of Biological Sciences, 2012
Subchondral bone sclerosis is a well-recognised manifestation of osteoarthritis (OA). The osteocyte cell network is now considered to be central to the regulation of bone homeostasis; however, it is not known whether the integrity of the osteocyte cell ...
Anjali Jaiprakash, Indira Prasadam, Jian Q. Feng, Ying Liu, Ross Crawford, Yin Xiao
doaj  

Osteocyte necroptosis drives osteoclastogenesis and alveolar bone resorption during orthodontic tooth movement

Scientific Reports
Orthodontic tooth movement (OTM) has been described as a bone remodeling process mediated by the expression of various inflammatory cytokines, including tumor necrosis factor-α (TNF-α). Necroptosis is a form of regulated cell death that is mainly induced
Fumitoshi Ohori, Hideki Kitaura, Aseel Marahleh, Jinghan Ma, Mariko Miura, Jiayi Ren, Kohei Narita, Ziqiu Fan, Angyi Lin, Itaru Mizoguchi   +9 more
doaj   +1 more source

A novel model of in vitro osteocytogenesis induced by retinoic acid treatment [PDF]

European Cells & Materials, 2012
Despite recent research which more and more stresses the importance of osteocytes in regulating bone and systemic mineral metabolism, current molecular and functional knowledge of osteocyte properties are still incomplete, mostly due to limited ...
D Mattinzoli, P Messa, A Corbelli, M Ikehata, C Zennaro, S Armelloni, M Li, L Giardino, MP Rastaldi   +8 more
doaj  

Microvascular Disease Associates with Larger Osteocyte Lacunae in Cortical Bone in Type 2 Diabetes Mellitus [PDF]

, 2023
Sebastian Zanner, Elliott Goff, Samuel Ghatan, Eva Maria Wölfel, Charlotte Ejersted, Gisela Kuhn, Ralph Müller, Morten Frost   +7 more
openalex   +1 more source

Exosomes derived from Wharton's jelly of human umbilical cord mesenchymal stem cells reduce osteocyte apoptosis in glucocorticoid-induced osteonecrosis of the femoral head in rats via the miR-21-PTEN-AKT signalling pathway

International Journal on Biological Sciences, 2019
Purpose: Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a common disease after long-term or high-dose glucocorticoid use. The pathogenesis of GIONFH is still controversial, and abnormal bone metabolism caused by glucocorticoids may ...
Ming‐jie Kuang, Ying Huang, Xige Zhao, Rui Zhang, Jian-xiong Ma, Da-chuan Wang, Xin-long Ma   +6 more
semanticscholar   +1 more source

The Emerging Role of Osteocytes in Cancer in Bone

JBMR Plus, 2019
Advances in the last decade have established the osteocyte, the most abundant cell in bone, as a dynamic and multifunctional cell capable of controlling bone homeostasis by regulating the function of both osteoblasts and osteoclasts.
Emily G Atkinson, Jesús Delgado‐Calle
doaj   +1 more source