Results 11 to 20 of about 31,027 (248)
Journal of Bone and Mineral Research, 2010 The last decade has provided a virtual explosion of data on the molecular biology and function of osteocytes. Far from being the “passive placeholder in bone,” this cell has been found to have numerous functions, such as acting as an orchestrator of bone
L. Bonewald
semanticscholar +3 more sources
Resveratrol Alleviates Diabetic Periodontitis-Induced Alveolar Osteocyte Ferroptosis Possibly via Regulation of SLC7A11/GPX4 [PDF]
Nutrients, 2023 The mode and mechanism of diabetic periodontitis-induced alveolar-osteocyte death are still unclear. This study aimed to investigate the occurrence of ferroptosis in alveolar osteocytes during diabetic periodontitis and the therapeutic potential of ...
Yue Li +8 more
semanticscholar +2 more sources
Annual Review of Physiology, 2020 Osteocytes are an ancient cell, appearing in fossilized skeletal remains of early fish and dinosaurs. Despite its relative high abundance, even in the context of nonskeletal cells, the osteocyte is perhaps among the least studied cells in all of ...
A. Robling, L. Bonewald
semanticscholar +4 more sources
FGF23 production by osteocytes [PDF]
Pediatric Nephrology, 2012 Fibroblast growth factor 23 (FGF23), a known regulator of phosphate homeostasis, is produced by cells residing in bone, namely, osteocytes, to target a distant organ, the kidney. Elevated FGF23 levels have recently been found systemically and in osteocytes in patients and animal models of chronic kidney disease.
Lynda F, Bonewald, Michael J, Wacker
openaire +4 more sources
The Osteocyte as the New Discovery of Therapeutic Options in Rare Bone Diseases
Frontiers in Endocrinology, 2020 Osteocytes are the most abundant (~95%) cells in bone with the longest half-life (~25 years) in humans. In the past osteocytes have been regarded as vestigial cells in bone, since they are buried inside the tough bone matrix.
Janak L. Pathak +3 more
doaj +2 more sources
Bone Research, 2019 Osteoarthritis (OA), long considered a primary disorder of articular cartilage, is commonly associated with subchondral bone sclerosis. However, the cellular mechanisms responsible for changes to subchondral bone in OA, and the extent to which these ...
Courtney M Mazur +2 more
exaly +2 more sources
Deep learning models to map osteocyte networks from confocal microscopy can successfully distinguish between young and aged bone. [PDF]
PLoS Computational BiologyOsteocytes, the most abundant and mechanosensitive cells in bone tissue, play a pivotal role in bone homeostasis and mechano-responsiveness, orchestrating the delicate balance between bone formation and resorption under daily activity. Studying osteocyte
Simon D Vetter +4 more
doaj +2 more sources
Journal of Biological Chemistry, 2017 Muscle and bone are closely associated in both anatomy and function, but the mechanisms that coordinate their synergistic action remain poorly defined. Myostatin, a myokine secreted by muscles, has been shown to inhibit muscle growth, and the disruption ...
Wei Zhao +2 more
exaly +2 more sources
Nature Communications, 2017 Control of osteocyte differentiation is not well understood. Here the authors show that the miR-23 cluster represses the TGF-β signalling repressor Prdm16 in osteoblasts, thus enhancing osteocyte differentiation and a low bone mass phenotype.
Huan-Chang Zeng +2 more
exaly +2 more sources
The influence of titanium particles on the functionality of osteocytes in bone remodeling: An In-vitro study. [PDF]
PLoS ONEBone remodeling is a tightly controlled process coordinated by osteocytes, which regulate both bone formation by osteoblasts and bone resorption by osteoclasts.
Neibal Almabrok +4 more
doaj +2 more sources