Results 31 to 40 of about 31,027 (248)
Bone, 2013 Apoptotic death of osteocytes was recognized over 15 years ago, but its significance for bone homeostasis has remained elusive. A new paradigm has emerged that invokes osteocyte apoptosis as a critical event in the recruitment of osteoclasts to a specific site in response to skeletal unloading, fatigue damage, estrogen deficiency and perhaps in other ...
Robert L, Jilka +2 more
openaire +2 more sources
Bundling of collagen fibrils influences osteocyte network formation during bone modeling
Scientific Reports, 2023 Osteocytes form a cellular network by gap junctions between their cell processes. This network is important since intercellular communication via the network is essential for bone metabolism.
Mana Hashimoto +10 more
doaj +1 more source
Identification of mechanics-responsive osteocyte signature in osteoarthritis subchondral bone
Bone & Joint Research, 2022 Aims: Osteoarthritis (OA) is a common degenerative joint disease. The osteocyte transcriptome is highly relevant to osteocyte biology. This study aimed to explore the osteocyte transcriptome in subchondral bone affected by OA.
Jun Zhou +7 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 The activation of hypoxia-inducible factor 1α (HIF-1α) signaling has promising implications for the treatment of bone diseases such as osteoporosis and skeletal fractures.
Kaizhe Chen +9 more
doaj +1 more source
Osteocyte Cellular Senescence [PDF]
Current Osteoporosis Reports, 2020 Senescent cells are now known to accumulate in multiple tissues with aging and through their inflammation (the senescence-associated secretory phenotype, SASP) contribute to aging and chronic diseases. Here, we review the roles of senescent osteocytes in the context of bone loss.Numerous studies have established that senescent osteocytes accumulate in ...
J. Farr +3 more
semanticscholar +3 more sources
PLoS ONE, 2012 Osteocytes are terminally differentiated osteoblasts which reside in a mineralized extracellular matrix (ECM). The factors that regulate this differentiation process are unknown.
Matthew Prideaux +3 more
doaj +1 more source
Characterization of self-organized osteocytic spheroids using mouse osteoblast-like cells
Journal of Biomechanical Science and Engineering, 2020 Osteocyte plays a central role as a commander in the bone to modulate bone remodeling processes. While the osteocyte is known to be differentiated from osteoblasts, understanding in mechanism of the osteocyte differentiation remained still poor.
Jeonghyun KIM +2 more
doaj +1 more source
Osteocyte differentiation and the formation of an interconnected cellular network in vitro [PDF]
European Cells & Materials, 2016 Extracellular matrix (ECM) stiffness and cell density can regulate osteoblast differentiation in two dimensional environments. However, it is not yet known how osteoblast-osteocyte differentiation is regulated within a 3D ECM environment, akin to that ...
MJ Mc Garrigle +4 more
doaj +1 more source
Journal of Clinical Investigation, 2020 Although the control of bone-resorbing osteoclasts through osteocyte-derived RANKL is well defined, little is known about the regulation of osteoclasts by osteocyte death.
D. Andreev +17 more
semanticscholar +1 more source
Bone Reports, 2016 Osteocytes and their lacunocanalicular network have been identified as the regulator of bone quality and function by exerting extensive influence over metabolic processes, mechanical adaptation, and mineral homeostasis.
Randee L. Hunter, Amanda M. Agnew
doaj +1 more source