Results 41 to 50 of about 31,027 (248)

Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease

Nature Communications, 2020
Osteocytes are master regulators of the skeleton. We mapped the transcriptome of osteocytes from different skeletal sites, across age and sexes in mice to reveal genes and molecular programs that control this complex cellular-network.
Scott E. Youlten, J. Kemp, John G Logan, Elena J Ghirardello, C. M. Sergio, Michael R. G. Dack, Siobhan E. Guilfoyle, V. D. Leitch, N. Butterfield, Davide Komla-Ebri, Ryan C. Chai, Alexander P Corr, James T. Smith, Sindhu T. Mohanty, J. Morris, Michelle M. McDonald, J. Quinn, Amelia R. McGlade, N. Bartonicek, M. Jansson, K. Hatzikotoulas, Melita D. Irving, A. Beleza‐Meireles, F. Rivadeneira, E. Duncan, J. Richards, D. Adams, C. Lelliott, R. Brink, T. G. Phan, J. A. Eisman, David M. Evans, E. Zeggini, P. Baldock, J. Bassett, Graham R. Williams, Peter I. Croucher   +36 more
semanticscholar   +1 more source

Osteocyte Dysfunction in Joint Homeostasis and Osteoarthritis

International Journal of Molecular Sciences, 2021
Structural disturbances of the subchondral bone are a hallmark of osteoarthritis (OA), including sclerotic changes, cystic lesions, and osteophyte formation.
Lanlan Zhang, C. Wen
semanticscholar   +1 more source

The role of inhibition of osteocyte apoptosis in mediating orthodontic tooth movement and periodontal remodeling: a pilot study

Progress in Orthodontics, 2021
Background Orthodontic tooth movement (OTM) has been shown to induce osteocyte apoptosis in alveolar bone shortly after force application. However, how osteocyte apoptosis affects orthodontic tooth movement is unknown.
Michele Kaplan, Zana Kalajzic, Thomas Choi, Imad Maleeh, Christopher L. Ricupero, Michelle N. Skelton, Madeleine L. Daily, Jing Chen, Sunil Wadhwa   +8 more
doaj   +1 more source

LPS-induced premature osteocyte senescence: Implications in inflammatory alveolar bone loss and periodontal disease pathogenesis.

Bone, 2020
Cellular senescence is associated with inflammation and extracellular matrix tissue remodeling through the secretion of proteins termed the senescence-associated secretory phenotype (SASP).
R. Aquino-Martinez, Jennifer L. Rowsey, Daniel G. Fraser, Brittany A. Eckhardt, S. Khosla, J. Farr, D. Monroe   +6 more
semanticscholar   +1 more source

Osteocytes and Primary Cilia

Current Osteoporosis Reports, 2023
Abstract Purpose of Review The purpose of this review is to provide a background on osteocytes and the primary cilium, discussing the role it plays in osteocyte mechanosensing. Recent Findings Osteocytes are thought to be the primary mechanosensing cells in bone tissue ...
Verbruggen, S.W., Sittichokechaiwut, A., Reilly, G.C.   +2 more
openaire   +4 more sources

The Impact of the Extracellular Matrix Environment on Sost Expression by the MLO-Y4 Osteocyte Cell Line

Bioengineering, 2022
Bone is a dynamic organ that can adapt its structure to meet the demands of its biochemical and biophysical environment. Osteocytes form a sensory network throughout the tissue and orchestrate tissue adaptation via the release of soluble factors such as ...
Robert T. Brady, Fergal J. O’Brien, David A. Hoey   +2 more
doaj   +1 more source

FOXO1 Mediates Advanced Glycation End Products Induced Mouse Osteocyte-Like MLO-Y4 Cell Apoptosis and Dysfunctions

Journal of Diabetes Research, 2019
Osteocyte plays an essential role in bone metabolism by regulating osteoblast and osteoclast activities. Dysfunction or apoptosis of osteocyte will severely endanger the bone homeostasis and result in bone diseases such as osteoporosis.
Citong Zhang, Wei Wei, Minghan Chi, Yao Wan, Xue Li, Manlin Qi, Yanmin Zhou   +6 more
doaj   +1 more source

YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling

Journal of Bone and Mineral Research, 2020
Bone fragility fractures are caused by low bone mass or impaired bone quality. Osteoblast/osteoclast coordination determines bone mass, but the factors that control bone quality are poorly understood.
Christopher D. Kegelman, Jennifer C. Coulombe, Kelsey M Jordan, D. Horan, L. Qin, A. Robling, V. Ferguson, T. Bellido, J. Boerckel   +8 more
semanticscholar   +1 more source

Osteocytes and Bone Metastasis [PDF]

Frontiers in Endocrinology, 2020
Bone is the most frequent site of breast cancer and prostate cancer metastasis, and one of the most common sites of metastasis for many solid tumors. Once cancer cells colonize in the bone, it imposes a major clinical challenge for the treatment of the disease, and fatality rates increase drastically.
Manuel A. Riquelme, Eduardo R. Cardenas, Jean X. Jiang   +2 more
openaire   +3 more sources

Importance of osteocyte-mediated regulation of bone remodelling in inflammatory bone disease

Swiss Medical Weekly, 2020
Although the impact of osteoblast-osteoclast crosstalk in bone remodelling has been intensively studied, the importance of osteocytes, descendants of osteoblasts, in this process has for a long time been neglected.
Johanna Intemann, David J.J De Gorter, Amy J Naylor, Berno Dankbar, Corinna Wehmeyer   +4 more
doaj   +1 more source