Results 51 to 60 of about 210,118 (389)
Journal of Biological Engineering, 2023 Three-dimensional (3D) cell cultures are to date the gold standard in biomedical research fields due to their enhanced biological functions compared to conventional two-dimensional (2D) cultures. 3D cell spheroids, as well as organoids, are better suited
Michael Killinger +5 more
doaj +1 more source
Structure-mechanics relationships of collagen fibrils in the Osteogenesis Imperfecta Mouse model [PDF]
, 2015 The collagen molecule, which is the building block of collagen fibrils, is a triple helix of two α1(I) chains and one α2(I) chain. However, in the severe mouse model of osteogenesis imperfecta (OIM), deletion of the COL1A2 gene results in the ...
Andriotis, OG +7 more
core +4 more sources
International Journal on Biological Sciences, 2021 Both osteoblasts and preosteoclasts contribute to the coupling of osteogenesis and angiogenesis, regulating bone regeneration. Astragaloside IV (AS-IV), a glycoside of cycloartane-type triterpene derived from the Chinese herb Astragalus membranaceus ...
Feng Wang +8 more
semanticscholar +1 more source
Enhanced Osteogenesis of Adipose-Derived Stem Cells by Regulating Bone Morphogenetic Protein Signaling Antagonists and Agonists. [PDF]
, 2016 UnlabelledAlthough adipose-derived stem cells (ASCs) are an attractive cell source for bone tissue engineering, direct use of ASCs alone has had limited success in the treatment of large bone defects.
Aghaloo, Tara L +11 more
core +2 more sources
Stem cell research & therapeutics, 2021 Background Osteogenesis is tightly coupled with angiogenesis during bone repair and regeneration. However, the underlying mechanisms linking these processes remain largely undefined.
Junjie Shen +8 more
semanticscholar +1 more source
Bone substitute effect on vascularization and bone remodeling after application of phVEGF165 transfected BMSC [PDF]
, 2012 VEGF (vascular endothelial growth factor) promotes vascularization and remodeling of bone substitutes. The aim of this study was to examine the effect of distinct resorbable ceramic carriers on bone forming capacities of VEGF transfected bone marrow ...
Beverungen, Mirjam +5 more
core +2 more sources
Current Overview of Osteogenesis Imperfecta
Medicina, 2021 Osteogenesis imperfecta (OI), or brittle bone disease, is a heterogeneous disorder characterised by bone fragility, multiple fractures, bone deformity, and short stature.
M. Deguchi +5 more
semanticscholar +1 more source
Cell Transplantation, 2021 Dental pulp stem cells (DPSCs) are one promising cell source of mesenchymal stem cells in bone tissue engineering. However, it remains unknown that the molecules and signaling pathways involved in osteogenesis of DPSCs. Hence, this study investigated the
Xinqi Huang +6 more
doaj +1 more source
Osteogenesis imperfecta and potential therapies
Journal of Education, Health and Sport, 2022 Background: Osteogenesis imperfecta (OI) is a genetically determined disorder of connective tissue. In this article we reviewed epidemiology, types of OI, pathophysiology, symptoms and potential therapies.
Mateusz Fabis +6 more
doaj +1 more source
Ceramic identity contributes to mechanical properties and osteoblast behavior on macroporous composite scaffolds. [PDF]
, 2012 Implants formed of metals, bioceramics, or polymers may provide an alternative to autografts for treating large bone defects. However, limitations to each material motivate the examination of composites to capitalize on the beneficial aspects of ...
Genetos, Damian C +4 more
core +4 more sources