Results 11 to 20 of about 148,060 (339)
Patterned Piezoelectric Scaffolds for Osteogenic Differentiation [PDF]
International Journal of Molecular Sciences, 2020 The morphological clues of scaffolds can determine cell behavior and, therefore, the patterning of electroactive polymers can be a suitable strategy for bone tissue engineering. In this way, this work reports on the influence of poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) electroactive micropatterned scaffolds on the proliferation and ...
Teresa Marques-Almeida +4 more
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Bisindoylmaleimide I enhances osteogenic differentiation [PDF]
Protein & Cell, 2012 The Wnt/β-catenin and bone morphogenetic proteins (BMPs) pathways play important roles in controlling osteogenesis. Using a cell-based kinase inhibitor screening assay, we identified the compound bisindoylmaleimide I (BIM) as a potent agonist of the cytosolic β-catenin accumulation in preosteoblast cells. Through suppressing glycogen synthase kinase 3β
Zhou, F.F., Huang, H.Z., Zhang, L.
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Histone modifications centric-regulation in osteogenic differentiation [PDF]
Cell Death Discovery, 2021 AbstractHistone modification critically contributes to the epigenetic control of gene expression by changing the configuration of chromatin and modifying the access of transcription factors to gene promoters. Recently, we observed that histone acetylation and crotonylation mediated the expression of endocytosis-related genes and tumor-related immune ...
Kun Li, Jinxiang Han, Ziqiang Wang
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The Regulatory Landscape of Osteogenic Differentiation [PDF]
Stem Cells, 2014 AbstractDifferentiation of osteoblasts from mesenchymal stem cells (MSCs) is an integral part of bone development and homeostasis, and may when improperly regulated cause disease such as bone cancer or osteoporosis. Using unbiased high-throughput methods we here characterize the landscape of global changes in gene expression, histone modifications, and
Anne-Mari, Håkelien +8 more
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Osteogenic Differentiation in Healthy and Pathological Conditions [PDF]
International Journal of Molecular Sciences, 2016 This review focuses on the osteogenic differentiation of mesenchymal stem cells (MSC), bone formation and turn-over in good and ill skeletal fates. The interacting molecular pathways which control bone remodeling in physiological conditions during a lifelong process are described.
VALENTI, Maria Teresa +2 more
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Dynamic and distinct histone modifications of osteogenic genes during osteogenic differentiation [PDF]
Journal of Biochemistry, 2015 Many skeletal diseases have common pathological phenotype of defective osteogenesis of bone marrow stromal cells (BMSCs), in which histone modifications play an important role. However, few studies have examined the dynamics of distinct histone modifications during osteogenesis. In this study, we examined the dynamics of H3K9/K14 and H4K12 acetylation;
Yong-Xing, Zhang +5 more
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Journal of Investigative Surgery, 2022 Background: Degenerative disk disease (DDD) remains the leading incentive of severe lumbago. DDD is mainly caused by degeneration of cartilage endplate (CEP).
Yunsheng Chen +5 more
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Utilizing osteocyte derived factors to enhance cell viability and osteogenic matrix deposition within IPN hydrogels [PDF]
, 2020 Many bone defects arising due to traumatic injury, disease, or surgery are unable to regenerate, requiring intervention. More than four million graft procedures are performed each year to treat these defects making bone the second most commonly ...
Hoey, David A. +2 more
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Scientific Reports, 2021 Mesenchymal stem cells (MSCs) are important in regenerative medicine because of their potential for multi-differentiation. Bone marrow, chorion and placenta have all been suggested as potential sources for clinical application.
Kulisara Marupanthorn +4 more
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Mesenchymal stem cell-derived exosomes have altered microRNA profiles and induce osteogenic differentiation depending on the stage of differentiation. [PDF]
PLoS ONE, 2018 Human mesenchymal stem cell (hMSC)-derived exosomes have shown regenerative effects, but their role in osteogenesis and the underlying mechanism are yet to be determined.
Xiaoqin Wang +4 more
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