Results 61 to 70 of about 138,476 (311)

KLF9 Promotes Osteogenic Differentiation of Dental Stem Cells by Negatively Regulating Notch1 Mediated Signaling Pathway

Frontiers in Bioscience-Landmark, 2023
Background: Human dental stem cells (DSCs) are excellent sources of cells for treating dental and craniofacial diseases. However, the mechanisms regulating DSC osteogenic differentiation are still unclear. In this study, we aimed to determine the role of
Xinyuan Zhao, Zizhao Mai, Ye Lu, Li Cui, Jinhua Yu   +4 more
doaj   +1 more source

Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/β-catenin signaling [PDF]

, 2012
Tissue inhibitor of metalloproteinases 1 (TIMP-1) is a matrix metalloproteinase (MMP)-independent regulator of growth and apoptosis in various cell types.
Avalos, Bartel, Behrens, Brew, C. Ries, Chirco, Clevers, Dasse, Day, Egea, Fata, Goff, Guedez, Guo, Huang, Huang, Ivey, Jho, Jiang, John, Joyce, Jung, K. Kehe, Liu, M. Jochum, MacDonald, Martinez, N. Rieth, P. Neth, Peter, Pittenger, Prockop, Reynolds, S. Zahler, Schiltz, Shtutman, Singer, T. Popp, Takahashi, Taube, V. Egea, Wingfield, Yi   +42 more
core   +1 more source

Multiscale Structuring of Hydroxyapatite via Two‐Photon Lithography of Nanocomposites

Advanced Functional Materials, EarlyView.
Hydroxyapatite scaffolds are of great interest in bone tissue engineering applications, ranging from 3D cell culture to regenerative medicine. Using two‐photon lithography of a transparent nanocomposite, hydroxyapatite microstructures with features ranging from submicron to centimeter‐scale are fabricated. This allows to mimic the natural bone geometry,
Leonhard Hambitzer, Jan Mathis Hornbostel, Richard Prediger, Sebastian Kluck, Michael Daub, Cornelia Lee‐Thedieck, Frederik Kotz‐Helmer   +6 more
wiley   +1 more source

Genetical stability and osteogenic ability of mesenchimal stem cells on demineralized bone matrices [PDF]

, 2015
Journal of Osseointegration Volume 7, Issue 1, 1 March 2015, Pages 2-7 Open Access Genetical stability and osteogenic ability of mesenchimal stem cells on demineralized bone matrices (Article) Pozzuoli, A.a, Gardin, C.b, Aldegheri, R.a, Bressan, E.c,
Aldegheri, R., Arrigoni, P., Biz, Carlo, Bressan, Eriberto, Calvo Guirado, J. L., Feroni, L., Gardin, Chiara, Isola, Maurizio, Pozzuoli, Assunta, Zavan, Barbara   +9 more
core   +1 more source

Generating Cell Surface Nucleated Hydrogels with an Artificial Membrane‐Binding Transglutaminase

Advanced Functional Materials, EarlyView.
Cell‐based therapies require advanced strategies to enhance cell delivery and bioactivity. Cell membrane engineering offers an avenue to impart new functions to delivered cells to boost their viability and function. Here, an artificial membrane‐binding transglutaminase is generated and biophysically characterized.
Rosalia Cuahtecontzi Delint, Tao Li, Kapil D. Patel, Will H. Zhang, Ben M. Carter, Graham J. Day, Adam W. Perriman   +6 more
wiley   +1 more source

Raman Microscopy at the Organic–Inorganic Interfaces in Human Calcified Aortic Valves Shows the Co‐Existence of Whitlockite Crystals and Carbonated Hydroxyapatite‐Mineralized Collagen Fibrils

Advanced Functional Materials, EarlyView.
This study advances our understanding of aortic valve stenosis by capturing spatially resolved chemical and structural changes at the nanoscale. The findings highlight the potential of combined Raman and electron microscopy for understanding calcification mechanisms across diverse tissue types.
Robin H. M. Van der Meijden, Carolien T. A Kuster, Amber van Broekhoven, Raphaela Allgayer, Luco Rutten, Rona Roverts, Marta Cerruti, Elena Macías‐Sánchez, Jan Hein Cornel, Salloua el Messaoudi, Anat Akiva, Nico Sommerdijk   +11 more
wiley   +1 more source

Notch signaling and fluid shear stress in regulating osteogenic differentiation

Frontiers in Bioengineering and Biotechnology, 2022
Osteoporosis is a common bone and metabolic disease that is characterized by bone density loss and microstructural degeneration. Human bone marrow-derived mesenchymal stem cells (hMSCs) are multipotent progenitor cells with the potential to differentiate
Yuwen Zhao, Yuwen Zhao, Kiarra Richardson, Kiarra Richardson, Rui Yang, Rui Yang, Zoe Bousraou, Yoo Kyoung Lee, Samantha Fasciano, Shue Wang   +9 more
doaj   +1 more source

The regulation of differentiation in mesenchymal stem cells [PDF]

, 2010
Peer reviewedPublisher ...
Augello, Andrea, De Bari, Cosimo
core   +1 more source

Injectable Dual‐Network Hydrogel System for Osteochondral Repair Combining Immunomodulation, Mechanical Adaptability, and Enhanced Tissue Integration

Advanced Functional Materials, EarlyView.
A UV‐triggered injectable dual‐network hydrogel is reported as the first application of bletilla striata polysaccharide (BSP) in osteochondral repair. By integrating methacrylamide‐modified BSP and nitrobenzaldehyde‐functionalized hyaluronic acid, the system achieves immunomodulation, mechanical reinforcement, and dynamic tissue adhesion, thereby ...
Jiaming Cui, Feifei Zhou, Yuan Luo, Tao Ouyang, Huiwu Zhang, Songmiao Cheng, Qiang Li, Xu Jiang, Yingying Yu, Yicheng Wang, Hong Ming   +10 more
wiley   +1 more source

Oncostatin M promotes osteogenic differentiation of tendon-derived stem cells through the JAK2/STAT3 signalling pathway

Journal of Orthopaedic Surgery and Research
Purpose Oncostatin M (OSM) is involved in the regulation of osteogenic differentiation and has a major role in the development of heterotopic ossification.
Jun Yang, Xiaolin Chen, Yueshu Wu, Gang Xu, Xiaochen Qu   +4 more
doaj   +1 more source