Results 141 to 150 of about 2,318 (174)
Some of the next articles are maybe not open access.
The Role of Cathepsins in Osteoimmunology
Critical Reviews in Eukaryotic Gene Expression, 2013Cathepsins are proteases comprising two small groups of serine and aspartic cathepsins and a large group of lysosomal cysteine cathepsins. Most of them are ubiquitously expressed throughout human tissues but some of them display a more restricted expression pattern and are involved in explicit tasks such as collagen degradation in the process of bone ...
Peter, Pietschmann +3 more
openaire +2 more sources
Cytokines and Bone: Osteoimmunology
2020Cytokines and hematopoietic growth factors have traditionally been thought of as regulators of the development and function of immune and blood cells. However, an ever-expanding number of these factors have been discovered to have major effects on bone cells and the development of the skeleton in health and disease (Table 1).
openaire +2 more sources
Cell biology of osteoimmunology
Wiener Medizinische Wochenschrift, 2010Osteoimmunology is defined as the research area focusing on the crosstalk between the immune system and the muskoskeletal system. After nearly a decade of research, we are now beginning to understand the basic principles of this crosstalk. It seems that almost all immune cells are capable of communicating with osteoblasts, osteoclasts, and their ...
openaire +2 more sources
Calcified tissue international
In rheumatoid arthritis (RA), local and systemic inflammation and immobility lead to both generalized and local bone loss and an increased risk of fractures. Osteo-immunology, the shared mechanisms and crosstalk between immunology and bone has revealed insight in the pathogenesis: the upregulated inflammatory cytokines (TNFa, IL-1 and IL6) and, apart ...
Raterman, Hennie G. +9 more
openaire +1 more source
In rheumatoid arthritis (RA), local and systemic inflammation and immobility lead to both generalized and local bone loss and an increased risk of fractures. Osteo-immunology, the shared mechanisms and crosstalk between immunology and bone has revealed insight in the pathogenesis: the upregulated inflammatory cytokines (TNFa, IL-1 and IL6) and, apart ...
Raterman, Hennie G. +9 more
openaire +1 more source
Clinical calcium, 2016
Bone serves not only as a locomotive organ but also as an organ instrumental in many other functions such as hematopoiesis. To this end, bone undergoes renewal by sequential resorption and formation. Bone resorption and formation are regulated by many systems including the endocrine, the nervous and the immune systems.
Takehito, Ono, Hiroshi, Takayanagi
openaire +1 more source
Bone serves not only as a locomotive organ but also as an organ instrumental in many other functions such as hematopoiesis. To this end, bone undergoes renewal by sequential resorption and formation. Bone resorption and formation are regulated by many systems including the endocrine, the nervous and the immune systems.
Takehito, Ono, Hiroshi, Takayanagi
openaire +1 more source
Editorial overview: Osteoimmunology
Bone, 2022Georg, Schett, Hiroshi, Takayanagi
openaire +2 more sources
Osteoimmunology: An Introduction
2012It has been almost 40 years since it was first observed that cells of the immune system could influence the functions of bone [1]. Since that time, significant strides have been made in our understanding of the interactions between hematopoietic, immune, and bone cells. This field is now known as “osteoimmunology,” which is a term that was first coined
openaire +1 more source
Clinical calcium, 2013
The immune and skeletal systems are closely related through a number of shared regulatory molecules including cytokines. Studies on bone destruction associated rheumatoid arthritis (RA) as well as identification of the various bone phenotypes found in immune-compromised genetically modified mice have highlighted the importance of the interplay between ...
Kazuo, Okamoto, Hiroshi, Takayanagi
openaire +1 more source
The immune and skeletal systems are closely related through a number of shared regulatory molecules including cytokines. Studies on bone destruction associated rheumatoid arthritis (RA) as well as identification of the various bone phenotypes found in immune-compromised genetically modified mice have highlighted the importance of the interplay between ...
Kazuo, Okamoto, Hiroshi, Takayanagi
openaire +1 more source