Results 21 to 30 of about 7,635 (213)

Osteocalcin and Osteonectin Expression in Canine Osteosarcoma [PDF]

Veterinary Pathology, 2016
Osteosarcoma (OSA) is a malignant heterogeneous primary bone tumor responsible for up to 90% of all primary bone tumors in dogs. In this study, osteocalcin (OC) and osteonectin (ON) immunoreactivity was evaluated in 23 canine OSAs, 4 chondrosarcomas, 4 fibrosarcomas, 2 hemangiosarcomas, and 4 histiocytic sarcomas.
A S, Wehrle-Martinez, K E, Dittmer, D, Aberdein, K G, Thompson   +3 more
openaire   +2 more sources

Expression of osteopontin and osteonectin in breast cancer [PDF]

Journal of Korean Medical Science, 1998
Osteopontin (OP) and osteonectin (ON) are bone matrix proteins produced by mammary and other cancers. These proteins may play a role in tumor invasion and metastasis through integrin-mediated signal transduction. We evaluated expressions of OP and ON in 253 resected infiltrating ductal carcinoma of the breast, using immunohistochemical staining and ...
Y W, Kim, Y K, Park, J, Lee, S W, Ko, M H, Yang   +4 more
openaire   +2 more sources

Cytokeratin - positive rib osteosarcoma metastasizing to the small intestine

Indian Journal of Pathology and Microbiology, 2014
Osteosarcoma (OS) is a malignant tumor in which osteoid or bone is produced directly by tumor cells. Some OS cells are positive for cytokeratin (CK) and epithelial membrane antigen by immunohistochemistry (IHC) and this may lead to a misdiagnosis of ...
Hiroko Kuwabara, Kazuhiko Fujita, Masako Yuki, Isao Goto, Toshiaki Hanafusa, Yuro Shibayama   +5 more
doaj   +1 more source

miR-214 inhibits the osteogenic differentiation of dental follicle cells in vitro

口腔疾病防治, 2020
Objective To investigate the effect of miR-214 on the osteogenic differentiation of dental follicle cells (DFCs). Methods Purified DFCs were cultured in vitro by bidirectional differential passage, with the untransfected DFCs as the control group (DFCs ...
WANG Zhiheng, ZUO Jie, WANG Mengqi, ZHU Shaojun, LIU Yishan   +4 more
doaj   +1 more source

Ganoderma lucidum, a promising agent possessing antioxidant and anti-inflammatory effects for treating calvarial defects with graft application in rats [PDF]

Acta Cirúrgica Brasileira, 2019
Purpose: Ganoderma lucidum, a kind of mushroom used for its antioxidant, anti-inflammatory, and immunomodulatory activities, was investigated in the present study for its possible healing effect on calvarial defects with bone grafts.
Nihat Laçin, Serhat Bozan İzol, Fikret İpek, Mehmet Cudi Tuncer   +3 more
doaj   +1 more source

Intertissular variations in osteonectin: A monoclonal antibody directed to bone osteonectin shows reduced affinity for platelet osteonectin

Journal of Bone and Mineral Research, 1991
Abstract Osteonectin, a major noncollagenous protein of bone, is also synthesized and secreted by various nonmineralized tissues and by platelets. To establish whether there are structural specificities of osteonectin according to its tissular origin, we raised 12 monoclonal antibodies against bovine bone osteonectin and screened them ...
L, Malaval, B, Darbouret, C, Preaudat, J P, Jolu, P D, Delmas   +4 more
openaire   +2 more sources

Effects of alloplastic graft material combined with a topical ozone application on calvarial bone defects in rats

Folia Morphologica, 2020
BACKGROUND: This study presents the evaluation of the damage in the bone tissue resulting from a calvarial defect in rats and the efficiency of exposure to an ozone application with an alloplastic bone graft on the calvarial bone damage.
N. Laçin, B. S. İzol, E. Gökalp Özkorkmaz, B. Deveci, E. Deveci   +4 more
doaj   +1 more source

Co-Targeting Prostate Cancer Epithelium and Bone Stroma by Human Osteonectin-Promoter-Mediated Suicide Gene Therapy Effectively Inhibits Androgen-Independent Prostate Cancer Growth. [PDF]

PLoS ONE, 2016
Stromal-epithelial interaction has been shown to promote local tumor growth and distant metastasis. We sought to create a promising gene therapy approach that co-targets cancer and its supporting stromal cells for combating castration-resistant prostate ...
Shian-Ying Sung, Junn-Liang Chang, Kuan-Chou Chen, Shauh-Der Yeh, Yun-Ru Liu, Yen-Hao Su, Chia-Yen Hsueh, Leland W K Chung, Chia-Ling Hsieh   +8 more
doaj   +1 more source

Osteonectin in matrix remodeling. A plasminogen-osteonectin-collagen complex.

Journal of Biological Chemistry, 1994
Osteonectin is an adhesive glycoprotein synthesized constitutively by osteoblasts, endothelial cells, and megakaryocytes. Bone-derived and platelet-derived osteonectins differ in their electrophoretic mobility and carbohydrate content, and each displays different affinities for collagen matrices.
R J, Kelm, N A, Swords, T, Orfeo, K G, Mann   +3 more
openaire   +2 more sources

Complex formation of human thrombospondin with osteonectin [PDF]

European Journal of Biochemistry, 1988
Human thrombospondin, a 450‐kDa glycoprotein isolated from platelets and endothelial cells, specifically interacts with osteonectin, a protein of 30 kDa isolated from bovine bones and human platelets. Using ELISA, purified osteonectin binds to solid‐phase‐adsorbed thrombospondin with a dissociation constant (Kd) of 0.7 nM.
P, Clezardin, L, Malaval, A S, Ehrensperger, P D, Delmas, M, Dechavanne, J L, McGregor   +5 more
openaire   +2 more sources