Osteocalcin and Osteonectin Immunoreactivity in the Diagnosis of Osteosarcoma [PDF]
American Journal of Clinical Pathology, 1997 Osteosarcomas (OSAs) can be difficult to distinguish histologically from tumors with significantly different biologic potentials and treatment protocols. The correct diagnosis of OSA relies on identification of malignant osteoblasts that are capable of producing neoplastic bone. To determine the use of immunohistochemistry for the diagnosis of OSA, 106
J C, Fanburg +6 more
openaire +2 more sources
Cytokeratin - positive rib osteosarcoma metastasizing to the small intestine
Indian Journal of Pathology and Microbiology, 2014 Osteosarcoma (OS) is a malignant tumor in which osteoid or bone is produced directly by tumor cells. Some OS cells are positive for cytokeratin (CK) and epithelial membrane antigen by immunohistochemistry (IHC) and this may lead to a misdiagnosis of ...
Hiroko Kuwabara +5 more
doaj +1 more source
miR-214 inhibits the osteogenic differentiation of dental follicle cells in vitro
口腔疾病防治, 2020 Objective To investigate the effect of miR-214 on the osteogenic differentiation of dental follicle cells (DFCs). Methods Purified DFCs were cultured in vitro by bidirectional differential passage, with the untransfected DFCs as the control group (DFCs ...
WANG Zhiheng +4 more
doaj +1 more source
Ganoderma lucidum, a promising agent possessing antioxidant and anti-inflammatory effects for treating calvarial defects with graft application in rats [PDF]
Acta Cirúrgica Brasileira, 2019 Purpose: Ganoderma lucidum, a kind of mushroom used for its antioxidant, anti-inflammatory, and immunomodulatory activities, was investigated in the present study for its possible healing effect on calvarial defects with bone grafts.
Nihat Laçin +3 more
doaj +1 more source
Journal of Bone and Mineral Research, 1991 Abstract Osteonectin, a major noncollagenous protein of bone, is also synthesized and secreted by various nonmineralized tissues and by platelets. To establish whether there are structural specificities of osteonectin according to its tissular origin, we raised 12 monoclonal antibodies against bovine bone osteonectin and screened them ...
L, Malaval +4 more
openaire +2 more sources
Folia Morphologica, 2020 BACKGROUND: This study presents the evaluation of the damage in the bone tissue resulting from a calvarial defect in rats and the efficiency of exposure to an ozone application with an alloplastic bone graft on the calvarial bone damage.
N. Laçin +4 more
doaj +1 more source
Co-Targeting Prostate Cancer Epithelium and Bone Stroma by Human Osteonectin-Promoter-Mediated Suicide Gene Therapy Effectively Inhibits Androgen-Independent Prostate Cancer Growth. [PDF]
PLoS ONE, 2016 Stromal-epithelial interaction has been shown to promote local tumor growth and distant metastasis. We sought to create a promising gene therapy approach that co-targets cancer and its supporting stromal cells for combating castration-resistant prostate ...
Shian-Ying Sung +8 more
doaj +1 more source
Osteonectin in matrix remodeling. A plasminogen-osteonectin-collagen complex.
Journal of Biological Chemistry, 1994 Osteonectin is an adhesive glycoprotein synthesized constitutively by osteoblasts, endothelial cells, and megakaryocytes. Bone-derived and platelet-derived osteonectins differ in their electrophoretic mobility and carbohydrate content, and each displays different affinities for collagen matrices.
R J, Kelm +3 more
openaire +2 more sources
Complex formation of human thrombospondin with osteonectin [PDF]
European Journal of Biochemistry, 1988 Human thrombospondin, a 450‐kDa glycoprotein isolated from platelets and endothelial cells, specifically interacts with osteonectin, a protein of 30 kDa isolated from bovine bones and human platelets. Using ELISA, purified osteonectin binds to solid‐phase‐adsorbed thrombospondin with a dissociation constant (Kd) of 0.7 nM.
P, Clezardin +5 more
openaire +2 more sources
The effect of graft application and simvastatin treatment on tibial bone defect in rats. A histological and immunohistochemical study [PDF]
Acta Cirúrgica Brasileira, 2019 Purpose: To evaluate histologically and immunohistochemically the bone regeneration after application of simvastatin on tibial bone defects in rats.
Nihat Laçin +4 more
doaj +2 more sources