Results 51 to 60 of about 53,476 (305)

Non-alcoholic fatty liver disease connections with fat-free tissues: A focus on bone and skeletal muscle [PDF]

, 2017
The estimates of global incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) are worrisome, due to the parallel burden of obesity and its metabolic complications. Indeed, excess adiposity and insulin resistance represent two of the major
Chiesa, Claudio, Donini, Lorenzo Maria, Lenzi, Andrea, Pacifico, Lucia, Poggiogalle, Eleonora   +4 more
core   +2 more sources

Endogenous Calcification Inhibitors in the Prevention of Vascular Calcification: A Consensus Statement From the COST Action EuroSoftCalcNet

Frontiers in Cardiovascular Medicine, 2019
The physicochemical deposition of calcium-phosphate in the arterial wall is prevented by calcification inhibitors. Studies in cohorts of patients with rare genetic diseases have shed light on the consequences of loss-of-function mutations for different ...
Magnus Bäck, Tamas Aranyi, M. Leonor Cancela, Miguel Carracedo, Natércia Conceição, Georges Leftheriotis, Vicky Macrae, Ludovic Martin, Yvonne Nitschke, Andreas Pasch, Daniela Quaglino, Frank Rutsch, Catherine Shanahan, Victor Sorribas, Flora Szeri, Flora Szeri, Pedro Valdivielso, Olivier Vanakker, Hervé Kempf   +18 more
doaj   +1 more source

Pathogenetic and diagnostic role of osteoprotegerin in the combined course of osteoarthritis and obesity

Journal of Education, Health and Sport, 2022
In recent years, it has been proven that the formation of OA can occur against the background of impaired bone metabolism. Bone remodeling is considered as a continuous complex process aimed at eliminating microdamages and updating the bone matrix. A
A. Litvynova, L. Pasiieshvili
doaj   +1 more source

Osteoprotegerin Protects against Muscular Dystrophy [PDF]

The American Journal of Pathology, 2015
Receptor-activator of NF-κB, its ligand RANKL, and the soluble decoy receptor osteoprotegerin are the key regulators of osteoclast differentiation and bone remodeling. Although there is a strong association between osteoporosis and skeletal muscle atrophy/dysfunction, the functional relevance of a particular biological pathway that synchronously ...
Sébastien S, Dufresne, Nicolas A, Dumont, Patrice, Bouchard, Éliane, Lavergne, Josef M, Penninger, Jérôme, Frenette   +5 more
openaire   +2 more sources

Suppression of AMP‐activated protein kinase reverses osteoprotegerin‐induced inhibition of osteoclast differentiation by reducing autophagy

Cell Proliferation, 2019
Osteoclasts (OC) are unique terminally differentiated cells whose primary function is bone resorption. We previously showed that osteoprotegerin (OPG) inhibits OC differentiation in vitro by enhancing autophagy via the adenosine monophosphate‐activated ...
Xishuai Tong, Chuang Zhang, Dong Wang, R. Song, Yonggang Ma, Ying Cao, Hongyan Zhao, Jianchun Bian, Jianhong Gu, Zongping Liu   +9 more
semanticscholar   +1 more source

Osteoprotegerin is a new marker of cardiovascular diseases [PDF]

Терапевтический архив, 2017
Osteoprotegerin (OPG) is a glycoprotein that is a representative of the tumor necrosis factor-α receptor superfamily. Information about the possible role of OPG in the development of cardiovascular diseases has begun to appear in the literature in recent
A F Verbovoy, I A Tsanava, E V Mitroshina, L A Sharonova   +3 more
doaj   +1 more source

EFFECT OF INFLIXIMAB ON PARAMETERS OF REMODELING OF ARTERIAL BLOODSTREAM, RANKL AND OSTEOPROTEGERIN LEVELS IN PATIENTS WITH RHEUMATOID ARTHRITIS

Научно-практическая ревматология, 2014
Objective. To study the effect of infliximab (INF) on serum levels of RANKL and osteoprotegerin (OPG), as well as on structural and functional properties of the vascular wall in patients with rheumatoid arthritis (RA).Material and Methods.
Larisa Aleksandrovna Knyazeva, N S Meshcherina   +1 more
doaj   +1 more source

Circulating levels of osteoprotegerin and sRANKL and the effect of methotrexate in patients with rheumatoid arthritis

Indian Journal of Rheumatology, 2018
Background: Receptor activator of nuclear factor κβ ligand (RANKL) and osteoprotegerin (OPG) are pivotal molecules involved in osteoclast activation and resorption.
Aadhaar Dhooria, Narendhiran Pandurangan, Karthik Vinay Mahesh, Suchet Sachdev, Aman Sharma, Shefali Sharma, Nidhi Gupta, Varun Dhir   +7 more
doaj   +1 more source

The Bone Markers Sclerostin, Osteoprotegerin, and Bone-Specific Alkaline Phosphatase Are Related to Insulin Resistance in Children and Adolescents, Independent of Their Association with Growth and Obesity

Hormone Research in Paediatrics, 2019
Background/Aims: Sclerostin, osteoprotegerin, and bone-specific alkaline phosphatase (B-ALP), which are primarily related to bone metabolism, have been linked with insulin resistance in adults.
J. Stanik, J. Kratzsch, Kathrin Landgraf, M. Vogel, J. Thiery, W. Kiess, A. Körner   +6 more
semanticscholar   +1 more source

Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity [PDF]

, 2017
Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1-mediated Cre expression is a useful strategy to genetically manipulate the mouse prostate. While grossly normal at birth, we observed
Ahmad, Imran, Blyth, Karen, Charlesworth, Gemma, Daroszewska, Anna, Ford, Catriona, King, Ayala, Leung, Hing Y., Loveridge, Carolyn J., Mui, Ernest J., Prior, Amanda, Rose, Lorraine, Salji, Mark, Sansom, Owen, Tan, Ee Hong, van ’t Hof, Rob J., Welsh, Michelle   +15 more
core   +2 more sources