Results 71 to 80 of about 21,209 (213)

Screening of hepatoma-derived growth factor with highly expression in HCC bone metastasis and its cellular biological effects

陆军军医大学学报
Objective To investigate the expression of hepatoma-derived growth factor (HDGF) in hepatocellular carcinoma (HCC) and its effects on DNA damage, proliferation, migration, epithelial mesenchymal transition (EMT), and expression of osteoprotegerin (OPG ...
ZHANG Xi, ZHANG Xi, HE Yongpeng, SHAO Gaohai   +3 more
doaj   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Pathophysiological roles of osteoprotegerin (OPG)

European Journal of Cell Biology, 2009
Osteoprotegerin (OPG) is a secreted glycoprotein central to bone turnover via its role as a decoy receptor for the receptor activator of nuclear factor kappaB ligand (RANKL) and has traditionally been linked to a number of bone-related diseases. However, there is additional evidence that OPG can promote cell survival by inhibiting TNF-related apoptosis-
Penny, Reid, Ingunn, Holen
openaire   +2 more sources

Osteoporosis and Periodontitis: Two‐Way Epidemiological and Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review investigates the main mechanistic pathways connecting local periodontitis to systemic osteoporosis. Seven interconnected mechanisms are identified. ABSTRACT Osteoporosis and periodontitis are highly prevalent, chronic inflammatory diseases that constitute a major global health burden.
Jia Chang, Geeta Madhuri Bhuvanagiri, Megan Dulkanchainun, Cunyu Wang   +3 more
wiley   +1 more source

Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship

Journal of Periodontal Research, EarlyView.
This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw, Ren Jie Jacob Chew, Charlene Enhui Goh, Ali A. Abdulkareem, Dana T. Graves   +4 more
wiley   +1 more source

Diagnostic Biomarkers of Periodontitis and Peri‐Implantitis: The Past, the Present, the Future

Journal of Periodontal Research, EarlyView.
Diagnostic biomarkers of periodontitis and peri‐implantititis from the past, through the present, and into the future. ABSTRACT In this narrative review we present our perspective on the past, present and future of periodontal and peri‐implantitis diagnostic biomarkers.
Denis F. Kinane, Başak Bıyıkoğlu
wiley   +1 more source

Periodontal Salutogenesis: Why Are Some People Resistant to Oral Microbial Dysbiosis and Destructive Inflammation?

Journal of Periodontal Research, EarlyView.
Emerging evidence suggests that periodontal health is not simply the absence of disease, but the result of a dynamic interaction between biological resilience, healthy lifestyles, adaptive coping mechanisms, and supportive environments. This results in a strong sense of coherence, which is not only a psychological state but also a biological state ...
Bruno G. Loos, Magda Feres, William V. Giannobile, Hatice Hasturk, Egija Zaura   +4 more
wiley   +1 more source

The role of osteoprotegerin in cardiovascular disease

Annals of Medicine, 2012
Osteoprotegerin (OPG) is a 401 amino acid N-glycosylated protein, which is highly expressed in a large number of tissues. OPG mainly binds to two ligands, i.e. RANKL (receptor activator of nuclear factor κB ligand) and TRAIL (tumor necrosis factor- related apoptosis-inducing ligand).
MONTAGNANA, Martina, LIPPI, Giuseppe, DANESE, Elisa, GUIDI, Giancesare   +3 more
openaire   +3 more sources

Combined Effects of Romosozumab and Zoledronate on the Development of Osteonecrosis of the Jaw

Oral Diseases, EarlyView.
ABSTRACT Objective This study aimed to assess the occurrence of medication‐related osteonecrosis of the jaw (MRONJ) in mice following the sequential administration of romosozumab and zoledronate and to confirm their inhibitory effects on osteoclast differentiation in vitro.
Hae‐Seo Park, Shihyun Kim, Seo‐Yeong An, Reuben H. Kim, Jongho Choi, Moon‐Young Kim   +5 more
wiley   +1 more source