Results 71 to 80 of about 20,163 (204)

Pathophysiological roles of osteoprotegerin (OPG)

European Journal of Cell Biology, 2009
Osteoprotegerin (OPG) is a secreted glycoprotein central to bone turnover via its role as a decoy receptor for the receptor activator of nuclear factor kappaB ligand (RANKL) and has traditionally been linked to a number of bone-related diseases. However, there is additional evidence that OPG can promote cell survival by inhibiting TNF-related apoptosis-
Penny, Reid, Ingunn, Holen
openaire   +2 more sources

Osteoprotegerin as a Marker of Atherosclerosis in Diabetic Patients [PDF]

International Journal of Endocrinology, 2013
Atherosclerosis is the principal cause of cardiovascular disease (CVD) and has many risk factors, among which is diabetes. Osteoprotegerin (OPG) is a soluble glycoprotein, involved in bone metabolism. OPG is also found in other tissues, and studies have shown that it is expressed in vascular smooth muscle cells.
Augoulea, A., Vrachnis, N., Lambrinoudaki, I., Dafopoulos, K., Iliodromiti, Z., Daniilidis, A., Varras, M., Alexandrou, A., Deligeoroglou, E., Creatsas, G.   +9 more
openaire   +4 more sources

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

LGR4 (GPR48): The Emerging Inter-Bridge in Osteoimmunology

Biomedicines
Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4), a member of the G-protein-coupled receptor (GPCR) family, has been implicated in various regulatory functions across multiple differentiation stages and numerous target sites in bone ...
Wonbong Lim
doaj   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Selected osteointegration markers in different timeframes after dental implantation: findings and prognostic value

Acta Biochimica Polonica
The study aimed to determine the osteointegration markers after dental implantation and evaluate their predictive value. The study was performed on 60 practically healthy persons who needed teeth rehabilitation using dental implants.
Emir Bayandurov, Zurab Orjonikidze, Sophio Kraveishvili, Ramaz Orjonikidze, George Ormotsadze, Sophio Kalmakhelidze, Tamar Sanikidze   +6 more
doaj   +1 more source

A Novel Small Molecule Which Increases Osteoprotegerin Expression and Protects Against Ovariectomy-Related Bone Loss in Rats

Frontiers in Pharmacology, 2019
The ratio of osteoprotegerin (OPG) to the receptor activator of NF-κB ligand (RANKL) is a key determinant in the regulation of bone metabolism. The study was performed to screen novel anti-osteoporotic drugs regulating OPG/RANKL ratio and evaluate their ...
Xiaowan Han, Shiqiang Gong, Shiqiang Gong, Ni Li, Xiao Wang, Peng Liu, Yanni Xu, Xiaobo He, Wei Jiang, Shuyi Si   +9 more
doaj   +1 more source

Extracellular vesicles from adipose tissue‐derived stem cells alleviate osteoporosis through osteoprotegerin and miR‐21‐5p

Journal of Extracellular Vesicles, 2021
Osteoporosis is one of the most common skeletal disorders caused by the imbalance between bone formation and resorption, resulting in quantitative loss of bone tissue.
Kyoung Soo Lee, Jeongmi Lee, Hark Kyun Kim, Seung Ho Yeom, Chang Hee Woo, Youn Jae Jung, Ye Eun Yun, So Young Park, Jihoon Han, Eunae Kim, Jae Hoon Sul, Jae Min Jung, Jae Hyung Park, Ji Suk Choi, Yong Woo Cho, Dong‐Gyu Jo   +15 more
doaj   +1 more source

The role of osteoprotegerin in cardiovascular disease

Annals of Medicine, 2012
Osteoprotegerin (OPG) is a 401 amino acid N-glycosylated protein, which is highly expressed in a large number of tissues. OPG mainly binds to two ligands, i.e. RANKL (receptor activator of nuclear factor κB ligand) and TRAIL (tumor necrosis factor- related apoptosis-inducing ligand).
MONTAGNANA, Martina, LIPPI, Giuseppe, DANESE, Elisa, GUIDI, Giancesare   +3 more
openaire   +3 more sources

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source