Results 71 to 80 of about 32,260 (226)

Osteoprotegerin Is a New Regulator of Inflammation and Angiogenesis in Proliferative Diabetic Retinopathy.

Investigative Ophthalmology and Visual Science, 2017
Purpose Osteoprotegerin (OPG) is a novel regulator of endothelial cell function, angiogenesis, and vasculogenesis. We correlated expression levels of OPG with those of the angiogenic and inflammatory factors vascular endothelial growth factor (VEGF) and ...
A. A. Abu El-Asrar, S. Struyf, G. Mohammad, M. Gouwy, Pieter Rytinx, M. M. Siddiquei, C. Hernández, Kaiser Alam, A. Mousa, G. De Hertogh, G. Opdenakker, R. Simó   +11 more
semanticscholar   +1 more source

Immunomodulatory Biomaterials for Bone and Soft Tissue Chronic Inflammation Diseases

Small Science, EarlyView.
This review analyzes immunomodulatory biomaterial strategies for treating chronic inflammatory disorders in bone and soft tissues. It explores emerging mechanisms for resolving inflammation while promoting tissue regeneration, offering insights for developing targeted immunotherapeutic approaches that bridge material science with immunology for ...
Yiming Li, Xudong Xie, Chong Ding, Shengming Zhang, Liangcong Hu, Bobin Mi, Mengfei Liu, Guohui Liu   +7 more
wiley   +1 more source

Circulating levels of osteoprotegerin and sRANKL and the effect of methotrexate in patients with rheumatoid arthritis

Indian Journal of Rheumatology, 2018
Background: Receptor activator of nuclear factor κβ ligand (RANKL) and osteoprotegerin (OPG) are pivotal molecules involved in osteoclast activation and resorption.
Aadhaar Dhooria, Narendhiran Pandurangan, Karthik Vinay Mahesh, Suchet Sachdev, Aman Sharma, Shefali Sharma, Nidhi Gupta, Varun Dhir   +7 more
doaj   +1 more source

Nanosecond Laser‐Assisted Direct Integration of Whitlockite onto Bone Implant Surfaces for Enhanced Bone Regeneration

Small Methods, EarlyView.
A laser‐assisted strategy enables the in situ formation of whitlockite coatings on bone implants through a magnesium calcium phosphate intermediate. This approach overcomes synthesis barriers, yielding bioactive surfaces that promote bone–implant integration and vascularization, offering a scalable route for next‐generation regenerative implants ...
Daehyeok Kwon, Hee Jae Hwang, Sun Hee Lee, Soon Jin Choi, Sangmin Song, Ji‐Young Lee, Hyeok Kim, Seung‐Hoon Um, Soyeon Park, Hyewon Kim, Yeon Jae Chang, Yu‐Chan Kim, Hojeong Jeon, Jimin Park, Hyung‐Seop Han   +14 more
wiley   +1 more source

Selected osteointegration markers in different timeframes after dental implantation: findings and prognostic value

Acta Biochimica Polonica
The study aimed to determine the osteointegration markers after dental implantation and evaluate their predictive value. The study was performed on 60 practically healthy persons who needed teeth rehabilitation using dental implants.
Emir Bayandurov, Zurab Orjonikidze, Sophio Kraveishvili, Ramaz Orjonikidze, George Ormotsadze, Sophio Kalmakhelidze, Tamar Sanikidze   +6 more
doaj   +1 more source

Effect of anatomical location (mandible vs maxilla) of dental implants on the BMP-2, BMP-7, sRANKL and OPG levels in periimplant crevicular fluid during osseointegration. A pilot study

Selcuk Dental Journal, 2019
Background:The aim of this study was to investigate levels of bone morphogenetic protein-2 (BMP-2), BMP-7, soluble receptor activator of nuclear factor-kB ligand (sRANKL) and osteoprotegerin (OPG) in the peri-implant crevicular fluid (PICF) of  implants ...
Mehmet Sağlam, Doğan Dolanmaz, Emrah Koçak, Burcu Poyraz, Özgür İnan, Niyazi Dündar, Sema Hakkı   +6 more
doaj   +1 more source

Osteoprotegerin Is more than a Possible Serum Marker in Liver Fibrosis: A Study into Its Function in Human and Murine Liver

Pharmaceutics, 2020
Osteoprotegerin (OPG) serum levels are associated with liver fibrogenesis and have been proposed as a biomarker for diagnosis. However, the source and role of OPG in liver fibrosis are unknown, as is the question of whether OPG expression responds to ...
Adhyatmika Adhyatmika, Leonie Beljaars, Kurnia S. S. Putri, Habibie Habibie, Carian E. Boorsma, Catharina Reker-Smit, Theerut Luangmonkong, Burak Guney, Axel Haak, Keri A. Mangnus, Eduard Post, Klaas Poelstra, Kim Ravnskjaer, Peter Olinga, Barbro N. Melgert   +14 more
doaj   +1 more source

Deciphering epigenetic regulation in postmenopausal osteoporosis: Current and future perspectives

VIEW, EarlyView.
In this perspective, the significant roles of microRNAs, long noncoding RNAs and circular RNAs in postmenopausal osteoporosis are thoroughly expounded. The advantages and limitations of typical noncoding RNAs as diagnostic biomarkers and therapeutic targets are summarized and discussed.
Xiumei Tang, Meiru Chen, Guixuan Xu, Yuan Li, Sen Guo, Yufeng Huang, Zhaoliang Hou, Xiaoling Hou, Zhijian Wei, Wenzhao Wang, Bing Ning   +10 more
wiley   +1 more source

A Novel Small Molecule Which Increases Osteoprotegerin Expression and Protects Against Ovariectomy-Related Bone Loss in Rats

Frontiers in Pharmacology, 2019
The ratio of osteoprotegerin (OPG) to the receptor activator of NF-κB ligand (RANKL) is a key determinant in the regulation of bone metabolism. The study was performed to screen novel anti-osteoporotic drugs regulating OPG/RANKL ratio and evaluate their ...
Xiaowan Han, Shiqiang Gong, Shiqiang Gong, Ni Li, Xiao Wang, Peng Liu, Yanni Xu, Xiaobo He, Wei Jiang, Shuyi Si   +9 more
doaj   +1 more source

Piezo‐type mechanosensitive cation channel 1 in bone biomechanics and its multidimensional distribution characteristics in skeletal tissue

VIEW, EarlyView.
PIEZO1 is highly correlated with mechanical stimulation, controlling bone growth and remodeling, while showing specific distribution characteristics under distinct loads. Upon dialectical review, this manuscript proposes that PIEZO1 could serve as a target for osteoporosis and a quantitative indicator for monitoring bone health in real‐time.
Chunyu Zhang, Yuehong Wang
wiley   +1 more source