Results 81 to 90 of about 32,260 (226)

Bergapten exerts inhibitory effects on diabetes-related osteoporosis via the regulation of the PI3K/AKT, JNK/MAPK and NF-κB signaling pathways in osteoprotegerin knockout mice

open access: yesInternational Journal of Molecular Medicine, 2016
Diabetes, as a serious metobolic disorder, poses global threat to human health. It is estimated that over 50 million individuals are already affected by diabetes.
Xuejiao Li   +3 more
semanticscholar   +1 more source

Alterations of bone proteins in medication‐related osteonecrosis of the jaw

open access: yesEuropean Journal of Oral Sciences, Volume 133, Issue 2, April 2025.
Abstract Changes in the protein expression pattern of osteoblastic lineage cells from the alveolar bone (OLAB) during medication‐related osteonecrosis of the jaw (MRONJ) have rarely been investigated. This lack of information is partly because of the limited availability of healthy samples and the lack of human alveolar bone cell lines for research ...
Andrea Schubert   +6 more
wiley   +1 more source

Osteoporosis in Systemic Autoinflammatory Diseases: A Case-Control Study

open access: yesFrontiers in Endocrinology, 2019
Objective: To assess if patients affected by systemic autoinflammatory diseases (SAIDs) present an increased risk of osteoporosis (OP).Methods: Forty adults patients referred to the Rheumatology Unit of Padova University Hospital affected by Familial ...
Sara Bindoli   +5 more
doaj   +1 more source

Osteoprotegerin deficiency aggravates methionine- choline- deficient diet-induced nonalcoholic steatohepatitis in mice [PDF]

open access: green, 2022
Shaobo Wu   +8 more
openalex   +1 more source

Expression of osteoprotegerin and its ligands, RANKL and TRAIL, in rheumatoid arthritis

open access: yesScientific Reports, 2016
Osteoprotegerin (OPG), receptor activator of nuclear factor-ΚB ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) have been involved in rheumatoid arthritis (RA) pathophysiology.
S. Remuzgo-Martínez   +10 more
semanticscholar   +1 more source

Effects of methotrexate on Wnt/β‐catenin signaling and glial activation in temporomandibular joint arthritis in rats

open access: yesEuropean Journal of Oral Sciences, EarlyView.
Abstract Rheumatoid arthritis is a chronic autoimmune disease that can affect the temporomandibular joint (TMJ) and cause pain. Methotrexate is widely used to control disease progression, but its effects on pain mechanisms are not fully understood. This study evaluated the antinociceptive effects of methotrexate on pain behavior, Wnt/β‐catenin pathway ...
Ana Carolina de Figueiredo Costa   +6 more
wiley   +1 more source

Osteoprotegerin mediates tumor-promoting effects of Interleukin-1beta in breast cancer cells

open access: yesMolecular Cancer, 2017
It is widely recognized that inflammation promotes breast cancer invasion and metastasis. Given the complex nature of the breast tumor inflammatory microenvironment, much remains to be understood of the molecular mechanisms that govern these effects.
S. Chung   +4 more
semanticscholar   +1 more source

Yerba Mate (Ilex paraguariensis A. St.‐Hil.) Reduces Oxidative Stress and Bone Resorption in Apical Periodontitis

open access: yesInternational Endodontic Journal, EarlyView.
ABSTRACT Aim Apical periodontitis (AP) is a highly prevalent chronic inflammatory disease that can exert systemic effects by releasing biochemical mediators that initiate and regulate the immune response. Yerba Mate (Ilex paraguariensis, YM), a popular plant broadly consumed in South America, is rich in biologically active compounds known for their ...
Carolina Sayuri Wajima   +9 more
wiley   +1 more source

EFFECT OF INFLIXIMAB ON PARAMETERS OF REMODELING OF ARTERIAL BLOODSTREAM, RANKL AND OSTEOPROTEGERIN LEVELS IN PATIENTS WITH RHEUMATOID ARTHRITIS

open access: yesНаучно-практическая ревматология, 2014
Objective. To study the effect of infliximab (INF) on serum levels of RANKL and osteoprotegerin (OPG), as well as on structural and functional properties of the vascular wall in patients with rheumatoid arthritis (RA).Material and Methods.
Larisa Aleksandrovna Knyazeva   +1 more
doaj   +1 more source

Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin &agr;v&bgr;3/FAK/AKT Pathway Suppression

open access: yesCirculation: Cardiovascular Genetics, 2017
Background— Pulmonary arterial remodeling characterized by increased vascular smooth muscle proliferation is commonly seen in life-threatening disease, pulmonary arterial hypertension (PAH).
Daile Jia   +6 more
semanticscholar   +1 more source

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