Results 91 to 100 of about 241,082 (329)

Extracellular vesicle-mediated delivery of miR-101 inhibits lung metastasis in osteosarcoma

Theranostics, 2020
Rationale: Extracellular vesicles (EVs) have emerged as novel mediators of cell-to-cell communication that are capable of the stable transfer of therapeutic microRNAs (miRNAs), and thus, EVs hold immense promise as a miRNA delivery system for cancer ...
Kailiang Zhang, Chuan Dong, Ming Chen, Tongtao Yang, Xin Wang, Yongheng Gao, Li-juan Wang, Y. Wen, Guanyin Chen, Xinli Wang, Xiuchun Yu, Yinglong Zhang, Pingshan Wang, Mingfu Shang, K. Han, Yong Zhou   +15 more
semanticscholar   +1 more source

Nanostructured Protein Surfaces Inspired by Spider Silk

Advanced Materials, EarlyView.
Harnessing recombinant spider silk technology, bioengineered spidroin variants enable the creation of functionalized nanostructured coatings with tunable affinity for specific targets, supporting a broad range of applications ‐ from antifouling surfaces and targeted drug delivery to advanced cell therapies and precision bio‐patterning via lithography ...
Martin Humenik, Thomas Scheibel
wiley   +1 more source

Mutations in the RB1 Gene in Argentine Retinoblastoma Patients and Uncommon Clinical Presentations [PDF]

, 2015
Background: Retinoblastoma, the most common ocular cancer of childhood, is caused by inactivation of the RB1 tumor suppressor gene in the developing retina.
Alonso, Cristina, Ferrer, Marcela Maria, Giliberto, Florencia, Luce, Leonela Natalia, Ottaviani, Daniela, Parma, Diana Lidia, Szijan, Irena   +6 more
core   +1 more source

WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 expression in an m6A-dependent manner

Cell Death and Disease, 2020
N6-methyladenosine (m6A) regulators are involved in the progression of various cancers via regulating m6A modification. However, the potential role and mechanism of the m6A modification in osteosarcoma remains obscure. In this study, WTAP was found to be
Shijie Chen, Yuezhan Li, Shuang Zhi, Zhiyu Ding, Weiguo Wang, Yi Peng, Yan Huang, Ruping Zheng, Haiyang Yu, Jianlong Wang, Minghua Hu, Jinglei Miao, Jinsong Li   +12 more
semanticscholar   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Whole-exome analysis in osteosarcoma to identify a personalized therapy [PDF]

, 2017
Osteosarcoma is the most common pediatric primary non-hematopoietic bone tumor. Survival of these young patients is related to the response to chemotherapy and development of metastases.
Aretini, Paolo, Carletti, Raffaella, Chiappetta, Caterina, Civita, Prospero, De Gregorio, Veronica, DELLA ROCCA, Carlo, DI CRISTOFANO, Claudio, Franceschi, Sara, Lessi, Francesca, Mancini, Massimiliano, Mazzanti, Chiara M., Naccarato, Antonio G., Petrozza, Vincenzo, Puggioni, Chiara   +13 more
core   +1 more source

Multi‐Material Gradient Printing Using Meniscus‐enabled Projection Stereolithography (MAPS)

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
MAPS is a new vat‐free printing technique that utilizes programmed delivery of resin droplets with custom formulations to enable multi‐material gradient printing of 3D structures with user‐defined variations in mechanical stiffness, opacity, surface energy, cell densities, and magnetic properties. Abstract Light‐based additive manufacturing methods are
Puskal Kunwar, Arun Poudel, Ujjwal Aryal, Rui Xie, Zachary J. Geffert, Haven Wittmann, Daniel Fougnier, Tsung Hsing Chiang, Mathew M. Maye, Zhen Li, Pranav Soman   +10 more
wiley   +1 more source

MiR-33a Controls hMSCS Osteoblast Commitment Modulating the Yap/Taz Expression Through EGFR Signaling Regulation [PDF]

, 2019
Mesenchymal stromal cells (hMSCs) display a pleiotropic function in bone regeneration. The signaling involved in osteoblast commitment is still not completely understood, and that determines the failure of current therapies being used.
Alessandro, Riccardo, Bellavia, Daniele, Carina, Valeria, Conigliaro, Alice, Costa, Viviana, De Luca, Angela, Fini, Milena, Giavaresi, Gianluca, Raimondi, Lavinia, Salamanna, Francesca   +9 more
core   +1 more source

Copper and Iron‐Based Metal‐Organic Frameworks for Synergistic Cancer Phototherapies: Recent Advances, Challenges, and Future Prospects

Advanced Therapeutics, EarlyView.
The graphical abstract illustrates the combined effect of PTT and PDT using metal‐organic frameworks (MOFs) in a cancer treatment model. Tumor‐bearing mice are irradiated with different laser lights, which activate the MOF nanoparticles within cancer cells. The MOFs produce reactive oxygen species through PDT, while PTT elevates the temperature to kill
Kayalvizhi Samuvel Muthiah, Kalaiarasu Lakshminarayanan, Yu Chien Lin, Udesh Dhawan, Loganathan Rangasamy, Ren‐Jei Chung   +5 more
wiley   +1 more source