Results 91 to 100 of about 126,889 (304)

Stable Protein‐Based G‐Quadruplex‐Derived Supramolecular Bioinks as Tunable ECM‐Mimetic Constructs Assembled by Combining Non‐Covalent and Covalent Strategies

Advanced Materials, EarlyView.
Harnessing the synergistic interplay of supramolecular self‐assembly, under macromolecular crowding conditions, and enzymatic‐mediated covalent crosslinking toward a stable protein‐based G‐quadruplex‐derived supramolecular bioink. This bioinspired strategy enables the biofabrication of complex and tunable ECM‐mimetic constructs, providing a platform ...
Vera Sousa, Rita Sobreiro‐Almeida, Bart W. L. van den Bersselaar, E. W. Meijer, Ghislaine Vantomme, João Borges, João F. Mano   +6 more
wiley   +1 more source

Photo‐Triggered, Fast, and Fluorogenic Thiophene‐Based Cycloalkynes for the Bioorthogonal Fluorescent Labeling of 1,3‐Dipole‐Tagged Molecules in No‐Wash Conditions

Angewandte Chemie, EarlyView.
Thiophene is king! The fusion of thiophene rings to cycloalkynes super‐charged their copper‐free click chemistry applications, by (1) enhancing the alkyne reactivity (fastest cyclooctyne to date) and (2) rendering the alkyne fluorogenic (with fluorescence enhancement up to 150‐fold upon reaction), making these bioorthogonal reagents ideal for tracking ...
Jurgen Schulz, Zoeisha S. Chinoy, Tarek Khalaf, Yukang Li, Pengchen Ma, Dennis Svatunek, Kendall N. Houk, Frédéric Friscourt   +7 more
wiley   +2 more sources

SERPINH1 enhances the malignancy of osteosarcoma via PI3K-Akt signaling pathway

Translational Oncology
Background: Serpin Family H Member 1 (SERPINH1) may be involved in the regulation of occurrence and development of tumors. However, the role and mechanism of SERPINH1 in osteosarcoma remain poorly understood.
Kezhou Xia, Xinghan Huang, Yingchun Zhao, Isabelle Yang, Weichun Guo   +4 more
doaj   +1 more source

Inhibition of STAT3 blocks protein synthesis and tumor metastasis in osteosarcoma cells

Journal of Experimental & Clinical Cancer Research, 2018
Background Osteosarcoma is the most common bone cancer. Despite advances, molecular mechanisms associated with osteosarcoma have not been fully understood. Hence, an effective treatment for osteosarcoma has yet to be developed.
Dongqing Zuo, Kristen L Shogren, Jie Zang, Donna E Jewison, Brian E Waletzki, Alan L Miller, Scott H Okuno, Zhengdong Cai, Michael J Yaszemski, Avudaiappan Maran   +9 more
doaj   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

Screening drugs of Anemoside B4 for MFAP4 expression in osteosarcoma in PDTX to increase personalized medicine

Discover Oncology
Osteosarcoma is a group of malignant tumors with a variety of histological subtypes and biological characteristics. This type of tumor mainly affects bones and soft tissues and is commonly found in children and young people.
Lei Zhang, Lijuan Zeng, Jing Zhang, Zhiwei He, Xiaozhou Liu   +4 more
doaj   +1 more source

ONZIN Upregulation by Mutant p53 Contributes to Osteosarcoma Metastasis Through the CXCL5-MAPK Signaling Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: Gain-of-function of mutant p53 is associated with a high rate of lung metastasis in osteosarcoma. To investigate the mechanism of mutant p53-induced osteosarcoma metastasis, expression array analysis was performed, comparing non ...
Yanqin Zhang, Qianghua Hu, Guixin Li, Lili Li, Shoulei Liang, Yun Zhang, Jiayong Liu, Zhengfu Fan, Lin Li, Bingzheng Zhou, Yongxin Ruan, Xueli Yang, She’an Chen, Tianyang  Mu, Guowen Wang, Shunbin Xiong   +15 more
doaj   +1 more source

Intracortical Osteosarcoma [PDF]

, 1996
Intracortical osteosarcoma is the rarest form of osteosarcoma and typically occurs in the young. The authors describe a case of intracortical osteosarcoma arising in the femur of a 44-year-old woman.
Daniel Sudilovsky, Charles Zaloudek, James O. Johnston   +2 more
core   +1 more source