Results 91 to 100 of about 171,941 (345)
RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites
Advanced Science, EarlyView.At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo +10 more
wiley +1 more source
Discover OncologyOsteosarcoma is a group of malignant tumors with a variety of histological subtypes and biological characteristics. This type of tumor mainly affects bones and soft tissues and is commonly found in children and young people.
Lei Zhang +4 more
doaj +1 more source
Negative CT Contrast Agents for the Diagnosis of Malignant Osteosarcoma
Advanced Science, 2019 The current positive computed tomography (CT) contrast agents (PCTCAs) including clinical iodides, present high CT density value (CT‐DV). However, they are incapable for the accurate diagnosis of some diseases with high CT‐DV, such as osteosarcoma ...
Xianfu Meng +9 more
doaj +1 more source
Osteosarcoma Multi-Omics Landscape and Subtypes
, 2023 Osteosarcoma (OS) is the most common primary bone malignancy that exhibits remarkable histologic diversity and genetic heterogeneity. The complex nature of osteosarcoma has confounded precise molecular categorization, prognosis, and prediction for this ...
Shan Tang +3 more
core +1 more source
Advanced Science, EarlyView.NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu +10 more
wiley +1 more source
Angewandte Chemie, EarlyView.Oncogenic MYC is a transcription factor that is difficult to inhibit. However, precise positioning of an acrylamide electrophile in MAX to covalently bond to the unique Cys438 in MYC, enabled shortening and optimizing of MAX‐derived, helix‐constrained peptides with high‐affinity and selectivity.
Aline Dantas de Araujo +7 more
wiley +2 more sources
Inhibition of STAT3 blocks protein synthesis and tumor metastasis in osteosarcoma cells
Journal of Experimental & Clinical Cancer Research, 2018 Background Osteosarcoma is the most common bone cancer. Despite advances, molecular mechanisms associated with osteosarcoma have not been fully understood. Hence, an effective treatment for osteosarcoma has yet to be developed.
Dongqing Zuo +9 more
doaj +1 more source
"Limb Sparing Versus Amputation in Osteosarcoma: Istitute Rizzoli Experience"
, 1991 "Limb Sparing Versus Amputation in Osteosarcoma: Istitute Rizzoli ...
M. CAMPANACCI +7 more
core
NOTCH Signaling in Osteosarcoma
, 2023 The combination of neoadjuvant chemotherapy and surgery has been promoted for the treatment of osteosarcoma; however, the local recurrence and lung metastasis rates remain high.
Wei Wu +5 more
core +1 more source
Advanced Science, EarlyView.This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao +12 more
wiley +1 more source