Results 141 to 150 of about 116,442 (313)

LncRNA HOXA-AS3 promotes cell proliferation and invasion via targeting miR-218-5p/FOXP1 axis in osteosarcoma

Scientific Reports
Osteosarcoma is an aggressive form of bone cancer and affects the health in children and adolescents. Although conventional treatment improves the osteosarcoma survival, some patients have metastasis and drug resistance, leading to a worse prognosis ...
Rong Li, Pingbo Chen, Yubo Zhou, Yi Lang, Changhui Zhou, Jingqin Ren, Adilijiang Maimaitiyimin, Zhen Chen, Chengqing Liu, Abasi mainike, Lu Ding   +10 more
doaj   +1 more source

Benchmarking PathCLIP for Pathology Image Analysis [PDF]

arXiv
Accurate image classification and retrieval are of importance for clinical diagnosis and treatment decision-making. The recent contrastive language-image pretraining (CLIP) model has shown remarkable proficiency in understanding natural images. Drawing inspiration from CLIP, PathCLIP is specifically designed for pathology image analysis, utilizing over
arxiv  

Letter: Osteosarcoma--new hope. [PDF]

, 1975
C. H. G. Price
openalex   +1 more source

Downregulation of PRKCI inhibits osteosarcoma cell growth by inactivating the Akt/mTOR signaling pathway

Frontiers in Oncology
PRKCI is abnormally expressed in various cancers, but its role in osteosarcoma is unknown. This study aimed to explore the biological function of PRKCI in osteosarcoma and its potential molecular mechanism.
Liujing Qu, Yu Xin, Jieni Feng, Xiaolei Ren, Zuming Li, Xueru Chen, Guangyan Miao, Jiankun Chen, Chengming Sun, Yue Lu, Yue Lu   +10 more
doaj   +1 more source

Advanced Hybrid Deep Learning Model for Enhanced Classification of Osteosarcoma Histopathology Images [PDF]

arXiv
Recent advances in machine learning are transforming medical image analysis, particularly in cancer detection and classification. Techniques such as deep learning, especially convolutional neural networks (CNNs) and vision transformers (ViTs), are now enabling the precise analysis of complex histopathological images, automating detection, and enhancing
arxiv  

Targeting SHMT2‐mediated membrane phospholipid remodeling for enhanced anti‐GCSCs treatment

Interdisciplinary Medicine, EarlyView.
Depletion of serine via serine hydroxymethyltransferase‐2 (SHMT2) knockdown in gastric cancer (GC) disrupted the maintenance of gastric cancer stem cell stemness by inducing membrane phospholipid remodeling and aberrant CD44 shedding within membrane lipid rafts. The synthesized HA‐Exo‐si SHMT2 demonstrated enhanced therapeutic efficacy and safety in GC.
Liping Yang, Fangli Liao, Yanran Tong, Tong Huang, Yan‐e Du, Siyang Wen, Linshan Jiang, Lanlang Peng, Hua Sun, Gaoli Zhang, Weixian Chen   +10 more
wiley   +1 more source

DNA damage contributes to age‐associated differences in SARS‐CoV‐2 infection

Aging Cell, Volume 21, Issue 12, December 2022., 2022
Our data suggest DNA damage contributes to age‐associated differences in SARS‐CoV‐2 infection and provide a novel target for anti‐viral intervention. Abstract Coronavirus disease 2019 (COVID‐19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is known to disproportionately affect older individuals.
Rui Jin, Chang Niu, Fengyun Wu, Sixin Zhou, Tao Han, Zhe Zhang, Entao Li, Xiaona Zhang, Shanrong Xu, Jiadong Wang, Shen Tian, Wei Chen, Qinong Ye, Cheng Cao, Long Cheng   +14 more
wiley   +1 more source

SERPINH1 enhances the malignancy of osteosarcoma via PI3K-Akt signaling pathway

Translational Oncology
Background: Serpin Family H Member 1 (SERPINH1) may be involved in the regulation of occurrence and development of tumors. However, the role and mechanism of SERPINH1 in osteosarcoma remain poorly understood.
Kezhou Xia, Xinghan Huang, Yingchun Zhao, Isabelle Yang, Weichun Guo   +4 more
doaj  

Polymorphisms of vascular endothelial growth factor on prognosis in osteosarcoma patients

, 1969
Zhao Dong-Ju, Aiju Xiao, Tian Yun-Jiao, Zhang Ming-qiu   +3 more
openalex   +1 more source

Integration of single-cell and bulk analysis reveals TBXAS1 as a key platelet-related gene causing poor prognosis in osteosarcoma

Frontiers in Genetics
BackgroundPlatelets are associated with poor prognosis in most tumors, but their specific pathogenic mechanism in osteosarcoma is not yet clear. The objective of this study is to conduct an in-depth analysis of how genes closely related to platelet ...
Han Liu, Wacili Da, Jianhua Mu, Xuanhong He, Zhuangzhuang Li, Taojun Gong, Jingjing Wang, Li Min, Minxun Lu, Chongqi Tu   +9 more
doaj   +1 more source