Results 151 to 160 of about 134,783 (292)

Move beyond free radical theory of aging

iMetaOmics, EarlyView.
Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley   +1 more source

Research Progress on the Evaluation and Clinical Value of Negative Surgical Margins in Osteosarcoma. [PDF]

Orthop Res Rev
Sun M, Meng X, Wang Z.
europepmc   +1 more source

Supplemental Figure 1 from Identification of Novel Ezrin Inhibitors Targeting Metastatic Osteosarcoma by Screening Open Access Malaria Box

, 2023
Haydar Çelik, Sung-Hyeok Hong, Daisy D. Colón-López, Jenny Han, Yasemin Saygıdeğer, Tsion Z. Minas, Matthew Swift, Mikell Paige, Eric Glasgow, Jeffrey A. Toretsky, Jürgen Bosch, Aykut Üren   +11 more
openalex   +1 more source

circ-ANKS1B facilitates osteosarcoma cell proliferation and invasiveness via upregulating Ki-67 expression by sponging miR-149-5p [PDF]

, 2020
Hao Yang, Yujie Liu, Chao Li, Yilin Liu, Liang Zhao, Yuqiang Wang, Yang Zhang, Min Zhang, Limin Wang   +8 more
openalex   +1 more source

Comprehensive assessment of unfolded protein response and its association with tumor progression in pan‐cancer

iMetaOmics, EarlyView.
Schematic of the study design. In this study, we developed a comprehensive unfolded protein response (UPR) gene signature and applied it to systematically characterize the UPR landscape across multiple cancer types. By integrating bulk and single‐cell transcriptomic data, we revealed substantial inter‐ and intra‐tumoral heterogeneity in UPR activity ...
Xinyu Yang, Faming Zhao, Jing Yang, Xinran Xia, Liwei Chen, Peng Zeng, Liang Chen, Yanxia Hu, Xia Sheng   +8 more
wiley   +1 more source

Supplementary Document from Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity

, 2023
Walied Kamel, Eiji Sugihara, Hiroyuki Nobusue, Sayaka Yamaguchi‐Iwai, Nobuyuki Onishi, Kenta Maki, Yumi Fukuchi, Koichi Matsuo, Akihiro Muto, Hideyuki Saya, Takatsune Shimizu   +10 more
openalex   +1 more source

CA9 is an important molecular marker for the prognosis of osteosarcoma patients [PDF]

, 2020
Jiguang Chen, Jian Wang, An Wang, Jiangming Yu   +3 more
openalex   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, EarlyView.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Methionine Restriction Alone Induces T-cell-mediated Immunotherapy of Osteosarcoma in a Syngeneic Mouse Model. [PDF]

In Vivo
Mizuta K, Kubota Y, Aoki Y, Morinaga S, Asano Y, Miyashi Y, Bouvet M, Tome Y, Nishida K, Hoffman RM.   +9 more
europepmc   +1 more source

Supplementary Figure S2 from Mitochondria-Targeted Doxorubicin: A New Therapeutic Strategy against Doxorubicin-Resistant Osteosarcoma

, 2023
Ilaria Buondonno, Elena Gazzano, Sae Rin Jean, Valentina Audrito, Joanna Kopecka, Marilù Fanelli, Iris C. Salaroglio, Costanzo Costamagna, Ilaria Roato, Eleonora Mungo, Claudia Maria Hattinger, Silvia Deaglio, Shana O. Kelley, Massimo Serra, Chiara Riganti   +14 more
openalex   +1 more source