Results 211 to 220 of about 134,783 (292)

SHP2 promotes osteosarcoma via regulating STAT3/TET3/HOXB2 signaling. [PDF]

Sci Rep
Yang H, Ji J.
europepmc   +1 more source

Targeting Wnt3a and Loxl2 Synergistically Induces Ferroptosis in Liver Cancer Stem Cells and Suppresses Tumorigenesis

Cancer Science, EarlyView.
Using bioinformatic analysis, LCSC models, and transgenic mice, we demonstrate that co‐inhibition of Wnt3a and Loxl2 potently triggers ferroptosis and inhibits orthotopic liver tumorigenesis. The enhanced antitumor effect upon dual targeting, mediated through ZEB1 upregulation, highlights a promising combinatory approach against HCC.
Guanghui Ren, Qingwei Cong, Jing Wang, Wenyue Gao, Yunpeng Guan, Lianxin Zhu, Ying Zhu   +6 more
wiley   +1 more source

Epidemiology and Prognosis of Patients With Osteosarcoma at Different Primary Sites: A SEER Population-Based Study. [PDF]

Cancer Rep (Hoboken)
Wang J, Zeng L, Li X, Fan X, Yan Z, Xu H, Canavese F, Li S, Zhi X.   +8 more
europepmc   +1 more source

Circ‐0030167/IGF2BP1 Induces Mitophagy‐Mediated Ferroptosis via HMOX1 mRNA Stabilization in Pancreatic Cancer

Cancer Science, EarlyView.
Our findings identify circ‐0030167/IGF2BP1/HMOX1 axis as a critical regulatory factor targeting mitochondria‐mediated ferroptosis, thereby presenting a novel therapeutic target for PC combination therapies. ABSTRACT Pancreatic cancer (PC) represents a highly aggressive malignancy characterized by a 5 year survival rate of less than 12%.
Qun Zhao, Xihao Yao, Jingjing Lu, Qiyang Chen, Zhiwei Wang, Xiaohong Li, Yuhua Lu   +6 more
wiley   +1 more source

Narciclasine triggers apoptosis in osteosarcoma cells via JNK-mediated extrinsic and intrinsic pathways. [PDF]

Int J Med Sci
Yang JS, Chou CH, Chen PN, Hsieh YH, Tang CH, Yang SF, Lu KH.   +6 more
europepmc   +1 more source

Reversal of MPPa‐PDT Resistance in Osteosarcoma by Targeting ROCK2‐Mediated Autophagy

Cell Proliferation, EarlyView.
ROCK2 competes with MST1 to bind to the aa 28‐198 region of SAV1 and then regulates the Hippo pathway to affect autophagy, resulting in the resistance of OS to MPPa‐PDT. Targeted inhibition of ROCK2 by screening for J059‐0149 increases the sensitivity of osteosarcoma to MPPa‐PDT. ABSTRACT Osteosarcoma (OS) is a primary bone tumour that occurs mostly in
Xuan Yi, Xueqiang Deng, Jianyong Deng, Chen Li, Hong Peng, Yunyan Du, Qing Li, Xiaohua Yan, Xin Hu, Yan Zheng, Shenliang Chen, Ting Xiong, Debin Xu, Leifeng Chen, Liang Hao   +14 more
wiley   +1 more source

Casuistry of oncological diseases in dogs, focusing on bone tumors treated at the Veterinary Hospital of the University of the Republic, Uruguay (2018-2023). [PDF]

Braz J Vet Med
Pereira MB, Solé RS, Barboza AD, Alves CF, Serdio PP.   +4 more
europepmc   +1 more source

Mechanisms Underpinning Osteosarcoma Genome Complexity and Evolution

Jose Espejo Valle-Inclán, Solange De Noon, Katherine Trevers, Hillary Elrick, M. Tanguy, Thomas Butters, Francesc Muyas, Fernanda Amary, Roberto Tirabosco, Adam Giess, Alona Sosinky, Greg Elgar, Adrienne M. Flanagan, Isidro Cortés‐Ciriano   +13 more
openalex   +1 more source

Inhibition of Fibroblast Activation Protein‐α Ameliorates Intervertebral Disc Degeneration via Reduced Vascular Invasion in Cartilage Endplate

Cell Proliferation, EarlyView.
Schematic illustration showing that FAP‐α promoted angiogenesis, cytokine release and ECM degradation in the CEP degeneration of the intervertebral disc through upregulating the PI3K/Akt/HIF‐1α/VEGFA pathway. ABSTRACT Intervertebral disc degeneration (IDD) is a primary cause of low back pain, with the development of new blood vessels being a key ...
Hao‐Wei Xu, Sheng‐Jie Chang, Shuo Wang, Xiao‐Wei Liu, Shan‐Jin Wang   +4 more
wiley   +1 more source