Temozolomide combined with irinotecan regresses a cisplatinum-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model. [PDF]
, 2017 Relapsed osteosarcoma is a recalcitrant tumor. A patient's cisplatinum (CDDP)-resistant relapsed osteosarcoma lung metastasis was previously established orthotopically in the distal femur of mice to establish a patient-derived orthotopic xenograft (PDOX)
Dry, Sarah M. +23 more
core +1 more source
Journal of Orthopaedic Surgery and Research, 2022 Background Osteosarcoma is highly malignant. The migration, invasion, and chemoresistance contribute to poor prognosis of osteosarcoma. Research reported that endogenous bornavirus-like nucleoprotein 3 pseudogene (EBLN3P) promotes the progression of ...
Ming-Xia Sun +4 more
doaj +1 more source
Cellular functions and molecular mechanisms of ubiquitination in osteosarcoma
Frontiers in Oncology, 2022 Although some advances have been made in the treatment of osteosarcoma in recent years, surgical resection remains the mainstream treatment. Initial and early diagnosis of osteosarcoma could be very difficult to achieve due to the insufficient ...
Jiaxun Song +8 more
doaj +1 more source
Ezrin-related phosphoinositide pathway modifies RhoA and Rac1 in human osteosarcoma cell lines [PDF]
, 2015 Selected Phosphoinositide-specific Phospholipase C (PI-PLC) enzymes occupy the convergence point of the broad range of pathways that promote Rho and Ras GTPase mediated signalling, which also regulate the activation of ezrin, a member of the ezrin ...
DELLA ROCCA, Carlo +2 more
core +1 more source
A chondroblastic osteosarcoma of the coronoid process mimicking a fragmented coronoid process in a dog [PDF]
, 2016 A 6-year-old Rhodesian Ridgeback was presented with a 1.5 year history of right forelimb lameness. Clinical, radiological and computed tomographic findings suggested the presence of fragmented medial coronoid process.
Cirkel, Koen +4 more
core +1 more source
Fluoroquinolone-mediated inhibition of cell growth, S-G2/M cell cycle arrest, and apoptosis in canine osteosarcoma cell lines. [PDF]
, 2012 Despite significant advancements in osteosarcoma research, the overall survival of canine and human osteosarcoma patients has remained essentially static over the past 2 decades.
Chen, Xinbin +5 more
core +2 more sources
Axial Multicentric Osteosarcoma in an English Cocker Spaniel [PDF]
, 2016 No abstract ...
Carvalho, S +6 more
core +3 more sources
The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model [PDF]
, 2020 2-Methoxyestradiol is one of the natural 17β-estradiol derivatives and a potential novel anticancer agent currently being under evaluation in advanced phases of clinical trials.
Cappello F. +8 more
core +1 more source
Disintegrin targeting of an αvβ3 integrin-over-expressing high-metastatic human osteosarcoma with echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro. [PDF]
, 2016 The in vitro efficacy of the disintegrin echistatin was tested on a high-metastatic variant of 143B human osteosarcoma, 143B-LM4, which over-expresses αvβ3 integrin. Echistatin is an RGD cyclic peptide and an antagonist of αvβ3 integrin.
Bouvet, Michael +7 more
core +4 more sources
The treatment of primary tumors of the femur with chemotherapy (if indicated), resection and reconstruction with an endoprosthesis [PDF]
, 1985 The treatment protocol of 15 patients with a primary tumor of the femur, including osteosarcoma, malignant fibrous histiocytoma and chondrosar-coma is presented. All patients had been selected for resection and reconstruction with an endoprosthesis.
Göeken, L.N.H. +10 more
core +3 more sources