Results 61 to 70 of about 255,852 (377)
A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies. [PDF]
, 2007 Canonical Wnt signaling is an osteo-inductive signal that promotes bone repair through acceleration of osteogenic differentiation by progenitors. Dkk-1 is a secreted inhibitor of canonical Wnt signaling and thus inhibits osteogenesis.
Angela Smolarz +9 more
core +3 more sources
MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients [PDF]
, 2020 Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the bloodstream.
Dewhurst, T +3 more
core +2 more sources
Advances on immunotherapy for osteosarcoma
Molecular CancerOsteosarcoma is the most common primary bone cancer in children and young adults. Limited progress has been made in improving the survival outcomes in patients with osteosarcoma over the past four decades.
Shengnan Yu, Xudong Yao
semanticscholar +1 more source
Osteosarcoma: a comprehensive review
SICOT-J, 2018 Osteosarcoma (OS) is a relatively rare tumor of bone with a worldwide incidence of 3.4 cases per million people per year. For most of the twentieth century, five-year survival rates for classic OS were very low. In the 1970s, the introduction of adjuvant
A. Misaghi +3 more
semanticscholar +1 more source
JAMA Oncology, 2020 Importance Osteosarcoma, the most common malignant bone tumor in children and adolescents, occurs in a high number of cancer predisposition syndromes that are defined by highly penetrant germline mutations.
L. Mirabello +49 more
semanticscholar +1 more source
Journal of the Belgian Society of Radiology, 2012 Background: A 25-year-old male patient presented with tooth pain and progressive swelling of his left cheek. Dental examination was unremarkable.
Vanhoenacker, F.M. +3 more
openaire +8 more sources
Journal of the American Academy of Orthopaedic Surgeons, 2009 Osteosarcoma, the most common bone sarcoma, affects approximately 560 children and adolescents annually in the United States. The incidence of new diagnoses peaks in the second decade of life. Twenty percent of patients present with clinically detectable metastases, with micrometastases presumed to be present in many of the remaining patients ...
Patrick J, Messerschmitt +4 more
openaire +3 more sources
The Journal of Hand Surgery, 2021 Osteogenic sarcoma is a malignant tumor that rarely affects the hand. When it does, it most often involves the phalanges or metacarpal heads. We present the case of a 51-year-old woman with a low-grade osteosarcoma affecting the trapezium bone of her left hand. A total trapeziectomy with partial removal of the first metatarsal, scaphoid, trapezoid, and
Raúl Rojas +4 more
openaire +5 more sources
Comparison of carboplatin and doxorubicin-based chemotherapy protocols in 470 dogs after amputation for treatment of appendicular osteosarcoma. [PDF]
, 2014 BackgroundMany chemotherapy protocols have been reported for treatment of canine appendicular osteosarcoma (OSA), but outcome comparisons in a single population are lacking.ObjectiveTo evaluate the effects of protocol and dose intensity (DI) on treatment
Burton, JH +4 more
core +2 more sources
Cancer Science, 2021 Osteosarcoma has been the most common malignant bone tumor in children and adolescents, while the 5‐y survival of osteosarcoma patients gained no significant improvement over the past decades.
Ting Lei, Hu Qian, Pengfei Lei, Yihe Hu
semanticscholar +1 more source