Results 81 to 90 of about 116,442 (313)

Systematic review on spheroids from adipose‐derived stem cells: Spontaneous or artefact state?

Journal of Cellular Physiology, Volume 237, Issue 12, Page 4397-4411, December 2022., 2022
Our proposed model of spheroid isolation from liposuction fat. The tissue disintegration releases the pre‐existing spheroids as intact structures. This could be the ideal technique to culture cells in suspension because it avoids a preliminary adhesion isolation step and thus an upstream cell selection.
Anna Barbara Di Stefano, Valentina Urrata, Marco Trapani, Francesco Moschella, Adriana Cordova, Francesca Toia   +5 more
wiley   +1 more source

Ultra-high dimensional confounder selection algorithms comparison with application to radiomics data [PDF]

arXiv, 2023
Radiomics is an emerging area of medical imaging data analysis particularly for cancer. It involves the conversion of digital medical images into mineable ultra-high dimensional data. Machine learning algorithms are widely used in radiomics data analysis to develop powerful decision support model to improve precision in diagnosis, assessment of ...
arxiv  

Osteosarcoma Cell‐Derived Migrasomes Promote Macrophage M2 Polarization to Aggravate Osteosarcoma Proliferation and Metastasis

Advanced Science, EarlyView.
Migrasomes are newly discovered organelles in migrating cells. This study finds that osteosarcoma cell‐derived migrasomes promote the tumor‐promoting phenotype of macrophages and further aggravate osteosarcoma malignant progression via milk fat globule‐EGF factor 8.
Wanshun Liu, Lei Li, Xiaoming Bai, Mengxue Zhang, Wei Lv, Yongbin Ma, Yuzhi Sun, Hongjing Zhang, Qing Jiang, Qingqiang Yao, Zhi‐Yuan Zhang   +10 more
wiley   +1 more source

Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy

Advanced Science, EarlyView.
Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang, Shu‐Ying Li, Fang‐Fei Li, Qin‐Yan Shi, Cheng‐Yong Tan, Xiao‐Jing Wang, Mi Li, Yun‐Bao Liu, Jing Jin, Yong Li, Shi‐Shan Yu   +10 more
wiley   +1 more source

TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and proliferation of osteosarcoma by promoting KANK1 degradation

Cell Death and Disease, 2021
Osteosarcoma is one of the most common primary malignancies in bones and is characterized by high metastatic rates. Circulating tumor cells (CTCs) derived from solid tumors can give rise to metastatic lesions, increasing the risk of death in patients ...
Mi Li, Wei Wu, Sisi Deng, Zengwu Shao, Xin Jin   +4 more
doaj   +1 more source

Tailoring Piezoelectric Nanogenerators and Microdevices for Cellular Excitation: Impact of Size and Morphology

Advanced Science, EarlyView.
Piezoelectric microdevices, composed of ZnO nanosheets acting as nanogenerators and grown on silicon microparticles, are designed and fabricated to deliver precise electrical cell stimulation. This study optimizes nanosheet growth and microparticle size to enhance electrical cell activation performance while minimizing cellular internalization.
Laura Lefaix, Marc Navarro, Carme Nogués, Andreu Blanquer, Gonzalo Murillo   +4 more
wiley   +1 more source

Negative CT Contrast Agents for the Diagnosis of Malignant Osteosarcoma

Advanced Science, 2019
The current positive computed tomography (CT) contrast agents (PCTCAs) including clinical iodides, present high CT density value (CT‐DV). However, they are incapable for the accurate diagnosis of some diseases with high CT‐DV, such as osteosarcoma ...
Xianfu Meng, Hua Zhang, Meng Zhang, Baoming Wang, Yanyan Liu, Yan Wang, Xiangming Fang, Jiawen Zhang, Zhenwei Yao, Wenbo Bu   +9 more
doaj   +1 more source

Identification of LARS as an essential gene for osteosarcoma proliferation through large-Scale CRISPR-Cas9 screening database and experimental verification

Journal of Translational Medicine, 2022
Background Osteosarcoma is one of the most malignant tumors, and it occurs mostly in children and adolescents. Currently, surgery and chemotherapy are the main treatments. The recurrence rate is high and the prognosis is often poor.
Wenhao Chen, Yuxiang Lin, Meichen Jiang, Qingshui Wang, Qiang Shu   +4 more
doaj   +1 more source

The Genetics of Osteosarcoma [PDF]

Sarcoma, 2012
Osteosarcoma is a primary bone malignancy with a particularly high incidence rate in children and adolescents relative to other age groups. The etiology of this often aggressive cancer is currently unknown, because complicated structural and numeric genomic rearrangements in cancer cells preclude understanding of tumour development.
Jeremy A. Squire, Maria Zielenska, Jeff W. Martin   +2 more
openaire   +3 more sources

Single‐Cell Analysis Clarifies Pathological Heterogeneity in Tenosynovial Giant Cell Tumor and Identifies Biomarkers for Predicting Disease Recurrence

Advanced Science, EarlyView.
MP3 tumor cells, a specific subpopulation of tumor cells in D‐TGCT, regulated the differentiation of CD34+ Fbs into MMP3+ Fbs and APOE+ Fbs through COL6A3 − (ITGAV + ITGB8) interaction. APOE+ Fbs activated IL‐1B+CCL20+ Mφs through the CXCL12/CXCR4 axis. IL‐1B+CCL20+ Mφs and MMP3+ Fbs participated in the local invasion of D‐TGCT.
Yubin Xie, Chen Chen, Fei Wu, Yiman Peng, Jing Su, Yang Zhao, Hongjie Huang, Zhong Alan Li, Yin Pei, Wencui Li, Yi He, Tianchen Xue, Chenxi Cao, Sui Peng, Xin Zhang, Weidong Song   +15 more
wiley   +1 more source