Results 81 to 90 of about 255,852 (377)
Osteosarcomas of the Heart [PDF]
The American Journal of Surgical Pathology, 1991 We reviewed nine primary cardiac sarcomas with osteosarcomatous differentiation. The patients' ages ranged from 24 to 67 (mean 38 years). All tumors were surgical specimens from the left atrium; many were clinically diagnosed as atypical myxomas. In eight cases complete excisions were attempted, one requiring reconstruction with grafting; one tumor was
Burke, Allen P., Virmani, Renu
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Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
MicroRNA-448 suppresses osteosarcoma cell proliferation and invasion through targeting EPHA7. [PDF]
PLoS ONE, 2017 Osteosarcoma is the most common type of malignant bone tumor, often affecting adolescents and children. MicroRNAs (miRNAs) are a group of small, non-protein coding, endogenous RNAs that play critical roles in osteosarcoma tumorigenesis.
Xiangkun Wu +5 more
doaj +1 more source
Telangiectatic Osteosarcoma [PDF]
Journal of Orthopaedic Surgery, 2013 Purpose. To review records of 8 patients with telangiectatic osteosarcoma (TOS) and determine whether pathologic fractures correlate with recurrence and survival. Methods. Records of 4 men and 4 women aged 17 to 44 (mean, 28) years treated for TOS were reviewed. Results. Of the 8 patients, 4 developed a pathologic fracture and 4 did not. In each group,
Jordi Colomina +3 more
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Identifying prognostic targets in metastatic prostate cancer beyond AR
FEBS Open Bio, EarlyView.Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng +13 more
wiley +1 more source
, 2010 Review on Bone: Osteoblastoma, with data on clinics, and the genes ...
de, Andrea CE, Hogendoorn, PCW
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Current trends in single‐cell RNA sequencing applications in diabetes mellitus
FEBS Open Bio, EarlyView.Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian +6 more
wiley +1 more source
Journal of Bone OncologyOsteosarcoma is the most common bone malignancy in children and adolescents. Patients with metastatic and recurrent osteosarcoma have poor prognosis.
Guannan Bai +4 more
doaj +1 more source
Clinical Medicine Insights: Oncology, 2013 Although osteosarcoma represents the second most common primary bone tumor, spinal involvement is rare, accounting for 3%–5% of all osteosarcomas. The most frequent symptom of osteosarcoma is pain, which appears in almost all patients, whereas more than 70% exhibit neurologic deficit. At a molecular level, it is a tumor of great genetic complexity and
P. Katonis +7 more
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Immunotherapy for osteosarcoma [PDF]
Human Vaccines & Immunotherapeutics, 2020 Osteosarcoma (OS) is the most common malignant bone tumor and often occurs in children. Chemotherapy with methotrexate, cisplatin, doxorubicin, and ifosfamide has greatly improved the prognosis of patients with OS, and most patients have been able to preserve their limbs.
Yoshihiro Matsumoto, Kenichiro Yahiro
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