Results 81 to 90 of about 134,783 (292)
GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion
Advanced Science, EarlyView.GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung +12 morewiley +1 more sourceSupplementary Table 1 from Caveolin-1 Reduces Osteosarcoma Metastases by Inhibiting c-Src Activity and Met Signaling
, 2023 Lara Cantiani, Maria Cristina Manara, Cinzia Zucchini, Paola De Sanctis, Monia Zuntini, Luisa Valvassori, Massimo Serra, Martina Olivero, Maria Flavia Di Renzo, Mario P. Colombo, Piero Picci, Katia Scotlandi +11 moreopenalex +1 more sourceGPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang +11 morewiley +1 more sourceSupplementary Table 5 from <i>SETD2</i> Is Recurrently Mutated in Whole-Exome Sequenced Canine Osteosarcoma
, 2023 Sharadha Sakthikumar, Ingegerd Elvers, Jaegil Kim, Maja L. Arendt, Rachael Thomas, Jason Turner-Maier, Ross Swofford, Jeremy A. Johnson, Steven E. Schumacher, Jessica Alföldi, Erik Axelsson, C. Guillermo Couto, William C. Kisseberth, Mats E. Pettersson, Gad Getz, Jennifer R. S. Meadows, Jaime F. Modiano, Matthew Breen, Marcin Kierczak, Karin Forsberg‐Nilsson, Voichita D. Marinescu, Kerstin Lindblad‐Toh +21 moreopenalex +1 more sourceContext‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis
Advanced Science, EarlyView.This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu +9 morewiley +1 more sourceSupplementary figure 1 from Characterization of Cell-Free DNA Size Distribution in Osteosarcoma Patients
, 2023 Sasimol Udomruk, Areerak Phanphaisarn, Thanat Kanthawang, Apiwat Sangphukieo, Songphon Sutthitthasakul, Siripong Tongjai, Pimpisa Teeyakasem, Patcharawadee Thongkumkoon, Santhasiri Orrapin, Sutpirat Moonmuang, Jeerawan Klangjorhor, Arnat Pasena, Pathacha Suksakit, Sivamoke Dissook, Pitithat Puranachot, Jongkolnee Settakorn, Tonapha Pusadee, Dumnoensun Pruksakorn, Parunya Chaiyawat +18 moreopenalex +1 more sourceLinking EORTC QLQ-C-30 and PedsQL/PEDQOL physical functioning scores in patients with osteosarcoma [PDF]
, 2022 Axel Budde, Katja Baust, Leonie Weinhold, Mark L. Bernstein, Stefan Bielack, Catharina Dhooge, Lars Hjorth, Katherine A. Janeway, Meriel Jenney, Mark Krailo, Neyssa Marina, Rajaram Nagarajan, Sigbjørn Smeland, Matthew R. Sydes, Patricia De Vos, Jeremy Whelan, Andreas Wiener, Gabriele Calaminus, Matthias Schmid +18 moreopenalex +1 more sourceTumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A‐Dependent hnRNPA2B1/COX‐2 Axis
Advanced Science, EarlyView.Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.Hongbo Li, Zehao Guo, Yutong Zou, Jiongfeng Zhang, Jixiang Shi, Xihong Fu, Jian Tu, Hao Yao, Xuanxuan Lu, Lili Wen, Xianbiao Xie +10 morewiley +1 more sourceImmunotherapy of osteosarcoma based on immune microenvironment modulation
Frontiers in ImmunologyOsteosarcoma is a highly malignant tumor with unsatisfactory therapeutic outcomes achieved by chemotherapy, radiotherapy, and surgery. As an emerging oncological treatment, immunotherapy has shown potential in the clinical management of many tumors but ...Heping Lian, Heping Lian, Jiakui Zhang, Shuna Hou, Shuang Ma, Jiachen Yu, Wei Zhao, Duoyi Zhao, Zhiyu Zhang +8 moredoaj +1 more sourceNegative CT Contrast Agents for the Diagnosis of Malignant Osteosarcoma
Advanced Science, 2019 The current positive computed tomography (CT) contrast agents (PCTCAs) including clinical iodides, present high CT density value (CT‐DV). However, they are incapable for the accurate diagnosis of some diseases with high CT‐DV, such as osteosarcoma ...Xianfu Meng, Hua Zhang, Meng Zhang, Baoming Wang, Yanyan Liu, Yan Wang, Xiangming Fang, Jiawen Zhang, Zhenwei Yao, Wenbo Bu +9 moredoaj +1 more source
