Results 81 to 90 of about 241,082 (329)

Tumor-targeting Salmonella typhimurium A1-R regresses an osteosarcoma in a patient-derived xenograft model resistant to a molecular-targeting drug. [PDF]

, 2016
Osteosarcoma occurs mostly in children and young adults, who are treated with multiple agents in combination with limb-salvage surgery. However, the overall 5-year survival rate for patients with recurrent or metastatic osteosarcoma is 20-30% which has ...
Chishima, Takashi, Dry, Sarah M, Eilber, Fritz C, Elliott, Irmina, Endo, Itaru, Federman, Noah, Hiroshima, Yukihiko, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Li, Yunfeng, Matsuyama, Ryusei, Murakami, Takashi, Nelson, Scott D, Russell, Tara, Singh, Arun, Tanaka, Kuniya, Yanagawa, Jane, Zhang, Yong, Zhao, Ming   +20 more
core   +2 more sources

Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma

Nature Communications, 2020
Osteosarcoma, an aggressive malignant cancer, has a high lung metastasis rate and lacks therapeutic target. Here, we reported that chromobox homolog 4 (CBX4) was overexpressed in osteosarcoma cell lines and tissues.
Xin Wang, Ge Qin, Xiao-Ting Liang, Wen Wang, Zhuo Wang, D. Liao, L. Zhong, Ruhua Zhang, Y. Zeng, Yuanzhong Wu, Tiebang Kang   +10 more
semanticscholar   +1 more source

Biologically Active Implants Prevent Mortality in a Mouse Sepsis Model

Advanced Healthcare Materials, EarlyView.
A modular, triple‐action titanium implant is developed to prevent implant‐associated infections by repelling bacteria, killing pathogens, and enhancing tissue integration. Coatings with phage cocktails targeting P. aeruginosa and S. aureus show significant bacterial reduction and improved survival in a mouse sepsis model.
Martin Stark, Fereshteh Bayat, Sara Rahmani, Mathura Thirugnanasampanthar, Taylor Kramer, Elise Schwarz, David Wilson, Jeffrey I. Weitz, Zeinab Hosseinidoust, Tohid F. Didar   +9 more
wiley   +1 more source

Osteosarcoma of the maxilla

Journal of the Belgian Society of Radiology, 2012
Background: A 25-year-old male patient presented with tooth pain and progressive swelling of his left cheek. Dental examination was unremarkable.
Vanhoenacker, Filip, Camerlinck, M., De Vuyst, D., Chapelle, K.   +3 more
openaire   +7 more sources

Genome-Informed Targeted Therapy for Osteosarcoma.

Cancer Discovery, 2018
Osteosarcoma is a highly aggressive cancer for which treatment has remained essentially unchanged for more than 30 years. Osteosarcoma is characterized by widespread and recurrent somatic copy-number alterations (SCNA) and structural rearrangements.
L. Sayles, Marcus R. Breese, Amanda L Koehne, Stanley G Leung, Alex G. Lee, Heng-Yi Liu, Aviv Spillinger, A. Shah, Bogdan Tanasa, Krystal M. Straessler, F. Hazard, Sheri L. Spunt, N. Marina, Grace E. Kim, Soo-Jin Cho, R. Avedian, D. Mohler, Mi-Ok Kim, S. G. Dubois, D. Hawkins, E. A. Sweet-Cordero   +20 more
semanticscholar   +1 more source

At the Pointy End of Mechanobiology: AFM for Transient Biomechanical Analysis

Advanced Healthcare Materials, EarlyView.
Stem cell mechanosensitivity governs lineage commitment through mechanotransduction, but capturing these transient changes in living cells remains challenging. Advanced atomic force microscopy enables high‐resolution analysis of mechanical properties, real‐time protein distribution, and gene expression, offering fresh insights into cell‐environment ...
Kaiwen Zhang, Chayla L. Reeves, Mehrnoosh Moghaddar, Kate E. Fox, Aaron Elbourne, Amy Gelmi   +5 more
wiley   +1 more source

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

Advanced Healthcare Materials, EarlyView.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo, Daniel Lozano, Antonio J. Salinas, María Vallet‐Regí   +3 more
wiley   +1 more source

Analysis of the Expression of Repetitive DNA Elements in Osteosarcoma [PDF]

, 2017
Osteosarcoma (OS) is a rare malignant bone tumor. It affects mostly young persons and has poor outcome with the present treatment. No improvement was observed since the introduction of chemotherapy.
Ho, Xuan D, Koks, Gea, Koks, Sulev, Lattekivi, Freddy, Le, Nghi TN, Le, Van Q, Maasalu, Katre, Martson, Aare, Nguyen, Hoang G, Nguyen, Van H, Phung, Phuong, Prans, Ele, Reimann, Ene, Trinh, Le H   +13 more
core   +1 more source

Designing the Next Generation of Biomaterials through Nanoengineering

Advanced Materials, EarlyView.
Nanoengineering enables precise control over biomaterial interactions with living systems by tuning surface energy, defects, porosity, and crystallinity. This review highlights how these nanoscale design parameters drive advances in regenerative medicine, drug delivery, bioprinting, biosensing, and bioimaging, while outlining key translational ...
Ryan Davis Jr., Ishaan Duggal, Nicholas A. Peppas, Akhilesh K. Gaharwar   +3 more
wiley   +1 more source

Cell line-specific efficacy of thermoradiotherapy in human and canine cancer cells in vitro [PDF]

, 2019
Objective Aims were to investigate sensitivity of various human and canine cancer cell lines to hyperthermia and the influence of particular treatment conditions, and to analyze the DNA-damage response and mode of cell death in cell line radiosensitized
Nytko, Katarzina J., Rohrer Bley, Carla, Scheidegger, Stephan, Thumser-Henner, Pauline, Weyland, Mathias S.   +4 more
core   +2 more sources