Results 241 to 250 of about 357,046 (292)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Eating Experiences of Patients With Cancer in the Hospital - A Qualitative Study. [PDF]

J Hum Nutr Diet
van Elst JM, Beukers K, Beijer S, Janssen-Heijnen M, Reyners AKL, Jager-Wittenaar H, de Haan JJ.   +6 more
europepmc   +1 more source

Finding the most promising indications for novel treatments in oncology. [PDF]

NPJ Precis Oncol
Eckhoff M, Klingelschmitt S, Van Ruijssevelt L, Grossmann S, Zichner T, Stümpges P, Roschewitz D, Mlecnik B, Merger M, Graen P, Kumar J, Devereson A, Wurzer S, Bleys J, Albrecht B, Hach D, Haslinger C.   +16 more
europepmc   +1 more source

Opioid prescribing practices in the U.S. and subsequent falls: a scoping review protocol. [PDF]

Syst Rev
Lovato VI, Torres MR, McClelland DJ, Lee JK, Saljuqi AT, Murphy BS.   +5 more
europepmc   +1 more source

Pharmacist participation as providers in Ohio Medicaid: an analysis of claims, services, and billing patterns, 2021-2025. [PDF]

Health Aff Sch
Murphy EM, Beatty SJ, Donneyong MM, Mann HJ.   +3 more
europepmc   +1 more source

Mapping sources of chronic disease-promoting products in retail environments: An analysis of co-location patterns of alcohol, tobacco, and fast-food retailers. [PDF]

PLoS One
D'Angelo Campos A, Delamater PL, Hall MG, Cox MJ, Golden SD.   +4 more
europepmc   +1 more source

Exploring feedback and feedforward in dental education using a followership model. [PDF]

Front Dent Med
Gummesson C, Lundegren N.
europepmc   +1 more source

Medicare Insurance Type and Broad Genomic Profiling in Metastatic Cancer.

JAMA Netw Open
Chow RD, Rothen J, Long JB, Soulos PR, Wang X, Mamtani R, Ma S, Kunst N, Dinan MA, Gross CP.   +9 more
europepmc   +1 more source