Results 1 to 10 of about 24,961 (203)
Aminoglycosides-Related Ototoxicity: Mechanisms, Risk Factors, and Prevention in Pediatric Patients
Pharmaceuticals, 2023 Aminoglycosides are broad-spectrum antibiotics largely used in children, but they have potential toxic side effects, including ototoxicity. Ototoxicity from aminoglycosides is permanent and is a consequence of its action on the inner ear cells via ...
Serena Rivetti +5 more
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BMC Pharmacology and Toxicology, 2023 Purpose Cisplatin is a widely used and effective chemotherapeutic agent for most solid malignant tumors. However, cisplatin-induced ototoxicity is a common adverse effect that limits the therapeutic efficacy of tumors in the clinic. To date, the specific
Haiyan Wang +11 more
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Cisplatin ototoxicity mechanism and antagonistic intervention strategy: a scope review
Frontiers in Cellular Neuroscience, 2023 Cisplatin is a first-line chemotherapeutic agent in the treatment of malignant tumors with remarkable clinical effects and low cost. However, the ototoxicity and neurotoxicity of cisplatin greatly limit its clinical application.
Yingru Li +29 more
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Detecting Novel Ototoxins and Potentiation of Ototoxicity by Disease Settings
Frontiers in Neurology, 2021 Over 100 drugs and chemicals are associated with permanent hearing loss, tinnitus, and vestibular deficits, collectively known as ototoxicity. The ototoxic potential of drugs is rarely assessed in pre-clinical drug development or during clinical trials ...
Allison B. Coffin +5 more
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Current Strategies to Combat Cisplatin-Induced Ototoxicity
Frontiers in Pharmacology, 2020 Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for this toxicity has not been fully elucidated.
Dehong Yu +17 more
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Insight into the current practice of ototoxicity monitoring during cisplatin therapy
Journal of Otolaryngology - Head and Neck Surgery, 2021 Background The aim of this study is to evaluate the current state of ototoxicity monitoring for patients receiving cisplatin chemotherapy in an academic medical center with particular attention to how closely monitoring adheres to national ototoxicity ...
N. M. Santucci +5 more
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Scientific ReportsNobiletin, a citrus polymethoxy flavonoid with antiapoptotic and antioxidative properties, could safeguard against cisplatin-induced nephrotoxicity and neurotoxicity.
Wenao Song +8 more
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Mechanistic insights into cisplatin-induced ototoxicity: the central role of transient receptor potential channels [PDF]
Frontiers in Molecular BiosciencesThis review systematically elucidates the molecular mechanisms underlying cisplatin-induced ototoxicity, with a particular focus on the pivotal role played by TRP channels.
Man Yu +4 more
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Cisplatin-Induced Ototoxicity in Rats Is Driven by RIP3-Dependent Necroptosis
Cells, 2019 Cisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to identify the involvement of receptor-interacting protein kinase (RIP)3-dependent ...
Mi-Jin Choi +8 more
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Kidney International, 2007 This paper reviews intriguing recent findings on the mechanisms of drug induced hearing loss caused by two major classes of therapeutic agents: the aminoglycoside antibiotics and cisplatin. Both drug categories are nephrotoxic as well as ototoxic. Aminoglycosides and cisplatin target the outer hair cells in the basal turn of the cochlea to cause high ...
Rybak, L.P., Ramkumar, V.
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