Results 91 to 100 of about 24,961 (203)
AntioxidantsCisplatin is an election chemotherapeutic agent used for many cancer treatments. Its cytotoxicity against neoplastic cells is mirrored by that taking place in healthy cells and tissues, resulting in serious adverse events.
Liliana Carles +6 more
doaj +1 more source
Scientific ReportsTransforming growth factor-β (TGF-β) signaling plays a significant role in multiple biological processes, including inflammation, immunity, and cell death. However, its specific impact on the cochlea remains unclear.
Yoshihiro Nitta +4 more
doaj +1 more source
South African Journal of Communication Disorders, 2019 Background: South Africa is a high-burden multi-drug-resistant tuberculosis (MDR-TB) country. Previously, standard MDR-TB treatment regimen in South Africa included kanamycin, an aminoglycoside, which can cause permanent hearing loss in patients.
Lebogang Ramma +2 more
doaj +1 more source
Establishing a pharmacotherapy induced ototoxicity programme within a service-learning approach
South African Journal of Communication Disorders, 2015 Pharmacotherapy-induced ototoxicity is growing, especially in developing countries such as South Africa. This highlights the importance of ototoxicity monitoring and management of hearing loss.
Natalie Schellack +4 more
doaj +1 more source
Journal of Clinical Medicine, 2019 Cisplatin is a chemotherapeutic agent that causes the irreversible death of auditory sensory cells, leading to hearing loss. Local administration of cytoprotective drugs is a potentially better option co-therapy for cisplatin, but there are strong ...
Blanca Cervantes +5 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2017 RNA editing is an important co- and post-transcriptional event that generates RNA and protein diversity. Aminoglycosides are a group of bactericidal antibiotics and a mainstay of antimicrobial therapy for several life-threatening infections.
Sijia Yan +11 more
doaj +1 more source
Role of RGS17 in cisplatin-induced cochlear inflammation and ototoxicity via caspase-3 activation
Frontiers in ImmunologyCisplatin is a chemotherapy drug used to treat different solid tumors, including ovarian, bladder, lung, and head and neck cancers. One of its significant side effects is ototoxicity, especially when high doses are required. Cisplatin-induced ototoxicity
Raheem F. H. Al Aameri +7 more
doaj +1 more source
A Review of Cisplatin-Associated Ototoxicity
Seminars in Hearing, 2019 Cisplatin, an effective antineoplastic drug used in the treatment of many cancers, has ototoxic potential, thus placing cancer patients, receiving this treatment, at risk of hearing loss.
J. Paken +3 more
semanticscholar +1 more source
Hesperidin activates Nrf2 to protect cochlear hair cells from cisplatin-induced damage
Redox ReportCisplatin is widely employed in clinical oncology as an anticancer chemotherapy drug in clinical practice and is known for its severe ototoxic side effects.
Jintao Lou +8 more
doaj +1 more source