Results 11 to 20 of about 24,961 (203)
Unraveling Endocannabinoid Signaling Pathways in Cisplatin-Induced Ototoxicity. [PDF]
FASEB JWe performed a comprehensive molecular profiling of the endocannabinoid (eCB) system (ECS) in an auditory Hair cell (HC)‐like cell line (1). Afterwards, we developed suitable in vitro and in vivo models of cisplatin‐induced ototoxicity where we identified distinct components of the ECS (CB2R, DAGLβ and ABHD6) as molecular targets of the drug (2 ...
Palaniappan S +12 more
europepmc +2 more sources
Frontiers in Cellular Neuroscience, 2023 Mitochondrial dysfunction is associated with ototoxicity, which is caused by external factors. Mitophagy plays a key role in maintaining mitochondrial homeostasis and function and is regulated by a series of key mitophagy regulatory proteins and ...
Hezhou Han +7 more
doaj +1 more source
Molecular Characteristics of Cisplatin-Induced Ototoxicity and Therapeutic Interventions
International Journal of Molecular Sciences, 2023 Cisplatin is a commonly used chemotherapeutic agent with proven efficacy in treating various malignancies, including testicular, ovarian, cervical, breast, bladder, head and neck, and lung cancer.
W. Tan, S. Vlajkovic
semanticscholar +1 more source
JCO Oncology Practice, 2023 Cisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ovarian, and head and neck cancers.
Asmi Chattaraj +3 more
semanticscholar +1 more source
Cisplatin-induced ototoxicity: From signaling network to therapeutic targets.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022 Administration of cisplatin, a common chemotherapeutic drug, has an inevitable side effect of sensorineural hearing loss. The main etiologies are stria vascularis injury, spiral ganglion degeneration, and hair cell death.
Xilu Wang +7 more
semanticscholar +1 more source
Ototoxicity monitoring in South African cancer facilities: A national survey
South African Journal of Communication Disorders, 2022 Background: National information regarding ototoxicity monitoring practices are limited for patients undergoing chemotherapy in South Africa. Objectives: To determine (1) the national status of ototoxicity monitoring implemented in private and public ...
Katerina Ehlert +2 more
doaj +1 more source
JAMA pediatrics, 2022 This pragmatic prospective implementation trial uses a rapid genotyping platform for the m.1555A>G variant to assess whether this technology could be implemented to avoid aminoglycoside-induced ototoxicity without disrupting normal clinical practice on ...
J. McDermott +20 more
semanticscholar +1 more source
Oxidative Stress and Inflammation Caused by Cisplatin Ototoxicity
Antioxidants, 2021 Hearing loss is a significant health problem that can result from a variety of exogenous insults that generate oxidative stress and inflammation. This can produce cellular damage and impairment of hearing.
V. Ramkumar +3 more
semanticscholar +1 more source
Journal of Pharmacy and Bioallied Sciences, 2021 Aim: The study explored the South African healthcare context for ototoxicity assessment and management from the audiologists’ perspectives. Materials and Methods: This was done through a survey research methodology that adopted a cross-sectional research
Katijah Khoza-Shangase, Nothando Masondo
doaj +1 more source
Mechanism and Prevention of Ototoxicity Induced by Aminoglycosides
Frontiers in Cellular Neuroscience, 2021 Aminoglycosides, a class of clinically important drugs, are widely used worldwide against gram-negative bacterial infections. However, there is growing evidence that aminoglycosides can cause hearing loss or balance problems.
Xiaolong Fu +12 more
semanticscholar +1 more source