Results 31 to 40 of about 24,961 (203)

A longitudinal community-based ototoxicity monitoring programme and treatment effects for drug-resistant tuberculosis treatment, Western Cape

South African Journal of Communication Disorders, 2022
Background: South Africa has a high burden of drug-resistant tuberculosis (DRTB) and until recently, ototoxic aminoglycosides were predominant in treatment regimens. Community-based ototoxicity monitoring programmes (OMPs) have been implemented for early
Lucia J. Stevenson, Leigh Biagio-de Jager, Marien A. Graham, De Wet Swanepoel   +3 more
doaj   +1 more source

The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicity

Scientific Reports, 2020
Platinum-based agents, such as cisplatin, form the mainstay of currently used chemotherapeutic regimens for several malignancies; however, the main limitations are chemoresistance and ototoxic side effects. In this study we used two different polyphenols,
F. Paciello, Anna Rita Fetoni, D. Mezzogori, R. Rolesi, Antonella Di Pino, G. Paludetti, C. Grassi, D. Troiani   +7 more
semanticscholar   +1 more source

Genome-wide analyses of platinum-induced ototoxicity in childhood cancer patients: Results of GO-CAT and United Kingdom MAGIC consortia

Frontiers in Pharmacology, 2023
Hearing loss (ototoxicity) is a major adverse effect of cisplatin and carboplatin chemotherapy. The aim of this study is to identify novel genetic variants that play a role in platinum-induced ototoxicity.
Evelien G. E. Hurkmans, Marije J. Klumpers, Cinzia Dello Russo, Cinzia Dello Russo, Ward De Witte, Henk-Jan Guchelaar, Hans Gelderblom, Anne-Marie Cleton-Jansen, Sita H. Vermeulen, Suzanne Kaal, Winette T. A. van der Graaf, Winette T. A. van der Graaf, Uta Flucke, Corrie E. M. Gidding, Hendrik W. B. Schreuder, Eveline S. J. M. de Bont, Huib N. Caron, Giovanna Gattuso, Elisabetta Schiavello, Monica Terenziani, Maura Massimino, Geoff McCowage, Sumanth Nagabushan, Sumanth Nagabushan, Anuja Limaye, Victoria Rose, Daniel Catchpoole, Andrea L. Jorgensen, Christopher Barton, Lucy Delaney, Daniel B. Hawcutt, Daniel B. Hawcutt, Munir Pirmohamed, Barry Pizer, Marieke J. H. Coenen, D. Maroeska W. M. te Loo   +35 more
doaj   +1 more source

Audiological testing for ototoxicity monitoring in adults with tuberculosis in state hospitals in Gauteng, South Africa

Southern African Journal of Infectious Diseases, 2016
Background: Ototoxicity monitoring during treatment of medical conditions, where the medications used are known to be toxic to the ear, is an important scope of practice of the audiologist; and, is an important clinical service aimed at enhancing ...
Katijah Khoza-Shangase, Megan Stirk
doaj   +1 more source

Practice of Monitoring Cisplatin-Induced Ototoxicity by Audiology, ENT, and Oncology Specialists: A Survey-Based Study in a Single Italian Medical Center

Audiology Research, 2023
Ototoxic drugs can result in hearing loss and tinnitus. Early detection of the ototoxic process can help minimize or prevent these consequences. The American Speech–Language–Hearing Association has provided guidelines for monitoring ototoxicity, whereas ...
Valeria Gambacorta, Eva Orzan, Mario Faralli, Mario Gullà, Ruggero Lapenna, Irene Baietta, Verena De Angelis, Giampietro Ricci   +7 more
doaj   +1 more source

High incidence of cisplatin-induced ototoxicity in paediatric patients in the Western Cape, South Africa

South African Journal of Oncology, 2018
Background: Fourteen million new cancer cases are reported annually, and up to 10% of those involve children below 15 years. Cisplatin, a commonly used anti-cancer drug for its high success rate, is associated with ototoxicity.
Mukovhe Phanguphangu, Lebogang Ramma
doaj   +1 more source

Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents.

Food and Chemical Toxicology, 2019
Cisplatin has dramatically improved the survival rate of cancer patients, but it has also increased the prevalence of hearing and neurological deficits in this population.
N. A. Santos, Rafaela Scalco Ferreira, A. C. Santos   +2 more
semanticscholar   +1 more source

Re-telling the story of aminoglycoside ototoxicity: tales from sub-Saharan Africa

Frontiers in Neurology
BackgroundAminoglycosides, such as Streptomycin, are cheap, potent antibiotics widely used Sub-Saharan Africa. However, aminoglycosides are the commonest cause of ototoxicity.
Adebolajo A. Adeyemo, Adebolajo A. Adeyemo, Babatunde Adedokun, Josephine Adeolu, Joshua O. Akinyemi, Olayemi O. Omotade, Odunayo M. Oluwatosin   +6 more
doaj   +1 more source

(-)-Epigallocatechin-3-gallate protects against NO-induced ototoxicity through the regulation of caspase- 1, caspase-3, and NF-κB activation. [PDF]

PLoS ONE, 2012
Excessive nitric oxide (NO) production is toxic to the cochlea and induces hearing loss. However, the mechanism through which NO induces ototoxicity has not been completely understood.
Su-Jin Kim, Jeong-Han Lee, Beom-Su Kim, Hong-Seob So, Raekil Park, Noh-Yil Myung, Jae-Young Um, Seung-Heon Hong   +7 more
doaj   +1 more source

Macrophage depletion protects against cisplatin-induced ototoxicity and nephrotoxicity

Science Advances
Cisplatin is a widely used anticancer drug with notable side effects including ototoxicity and nephrotoxicity. Macrophages, the major resident immune cells in the cochlea and kidney, are important drivers of both inflammatory and tissue repair responses.
C. Sung, Naoki Hayase, Peter S T Yuen, John Lee, Katharine A. Fernandez, Xuzhen Hu, Hui Cheng, R. A. Star, M. Warchol, Lisa L. Cunningham   +9 more
semanticscholar   +1 more source