Results 61 to 70 of about 24,961 (203)

Oncologists' views on ototoxicity monitoring in head and neck cancer patients: A South Indian qualitative study.

PLoS ONE
AimThe perspectives and practices of healthcare professionals regarding ototoxicity in individuals with head and neck cancers are important for the implementation of ototoxicity monitoring. The current study aims to explore the oncologist's awareness and
Varsha Shankar, Jayashree Seethapathy, Satish Srinivas, Raghu Nandhan, Prasanna Kumar Saravanam   +4 more
doaj   +1 more source

Migraine Features in Patients With Sudden Sensorineural Hearing Loss

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To investigate the prevalence of migraine features among patients with sudden sensorineural hearing loss (SSNHL) and evaluate potential clinical associations. Study Design Retrospective survey‐based study. Setting Single institution tertiary care center. Methods 168 adult patients with SSNHL were recruited.
Yalda Yazdani, Ella J. Lee, Amanda Francis, Saharnaz Nedjat, Mehdi Abouzari, Hamid R. Djalilian   +5 more
wiley   +1 more source

Computational Study on Potentially Active Antibacterial Compounds in Secondary Metabolites of Extremophilic Microorganisms

ChemistryOpen, EarlyView.
This study employed density functional theory (DFT) and conceptual DFT (CDFT) to calculate the structures and properties of potential antibacterial compounds derived from 16‐membered lactone ring‐containing secondary metabolites of extremophiles, as well as midecamycin.
Dilong Li, Yanni Wang, Yinhuan Huang, Hui Zhou, Xiaoyun Xia, Wei Huang, Chaojie Wang   +6 more
wiley   +1 more source

Pathogenesis of Age‐Related Hearing Loss and Therapeutic Strategies

Sensory Neuroscience, EarlyView.
ABSTRACT Age‐related hearing loss (ARHL) is a degenerative disorder of the auditory system, characterized by bilateral symmetrical sensorineural hearing loss that occurs with aging. As a highly prevalent age‐related condition worldwide, ARHL significantly impairs both the quality of life and mental health of the elderly.
Yu Xiao, Jiaxin Liu, Xiaohan Zhang, Miao Chang, Cheng Cheng, Yunhao Wu, Xiaolong Fu   +6 more
wiley   +1 more source

Glutathione carbon dots as an intracellular reactive oxygen species scavenger for reducing cisplatin‐induced ototoxicity

View
It is widely recognized that platinum‐based chemotherapy, particularly cisplatin therapy, can cause ototoxicity. At present, there are no Food and Drug Administration‐approved drugs to prevent or alleviate ototoxicity.
Yaqin Tu, Guorun Fan, Nan Wu, Bo Liu, Haiying Sun, Qiong Wang, Wenqing Zou, Hongjun Xiao, Songwei Tan   +8 more
doaj   +1 more source

Role and mechanism of FOXG1-related epigenetic modifications in cisplatin-induced hair cell damage

Frontiers in Molecular Neuroscience, 2023
Cisplatin is widely used in clinical tumor chemotherapy but has severe ototoxic side effects, including tinnitus and hearing damage. This study aimed to determine the molecular mechanism underlying cisplatin-induced ototoxicity.
Yu-rong Mu, Sheng-yu Zou, Ming Li, Yan-yan Ding, Xiang Huang, Zu-hong He, Wei-jia Kong   +6 more
doaj   +1 more source

Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection

Frontiers in Cellular Neuroscience, 2017
Evidence of significant hearing loss during the early days of use of cisplatin as a chemotherapeutic agent in cancer patients has stimulated research into the causes and treatment of this side effect.
Sandeep Sheth, D. Mukherjea, L. Rybak, V. Ramkumar   +3 more
semanticscholar   +1 more source

Usefulness of current candidate genetic markers to identify childhood cancer patients at risk for platinum-induced ototoxicity: Results of the European PanCareLIFE cohort study.

European Journal of Cancer, 2020
BACKGROUND Irreversible sensorineural hearing loss is a common side effect of platinum treatment with the potential to significantly impair the neurocognitive, social and educational development of childhood cancer survivors.
T. Langer, E. Clemens, L. Broer, L. Maier, A. Uitterlinden, A. D. de Vries, M. van Grotel, S. Pluijm, H. Binder, B. Mayer, Annika von dem Knesebeck, J. Byrne, E. van Dulmen-den Broeder, M. Crocco, D. Grabow, P. Kaatsch, M. Kaiser, C. Spix, L. Kenborg, J. Winther, C. Rechnitzer, H. Hasle, T. Kepák, A. V. D. van der Kooi, L. Kremer, J. Kruseová, S. Bielack, B. Sorg, S. Hecker-Nolting, C. Kuehni, M. Ansari, M. Kompis, H. H. van der Pal, R. Parfitt, D. Deuster, P. Matulat, A. Tillmanns, W. Tissing, J. Beck, S. Elsner, A. am Zehnhoff-Dinnesen, M. M. van den Heuvel-Eibrink, O. Zolk   +42 more
semanticscholar   +1 more source

The Role of Anatomy‐Based Fitting in Bimodal Rehabilitation: Choosing Electrode Arrays Based on Cochlear Length

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives To evaluate the clinical impact of anatomy‐based fitting (ABF) in cochlear implants for patients with asymmetric hearing loss. Study Design Prospective cohort study. Setting Tertiary referral center specializing in hearing disorders.
Andrea Canale, Arianna Daquino, Maria Gragnano, Claudia Filippini, Marco Boldreghini, Giuseppe Riva, Andrea Albera   +6 more
wiley   +1 more source

Exercise prehabilitation for brain health and sensory–cognitive function: Mechanistic insights into brain–body interactions

Experimental Physiology, EarlyView.
Abstract This mini review article presents a novel hypothesis for extending exercise prehabilitation into the domains of brain health and cognition. Whilst prehabilitation has been gaining popularity in cancer treatment, conferring significant positive benefits to numerous physiological indicators, including post‐operative infection and hospital length
Helen E. Nuttall, Daren Subar, Christopher J. Gaffney   +2 more
wiley   +1 more source