Results 71 to 80 of about 24,961 (203)

Protective Effects of Glucose-Related Protein 78 and 94 on Cisplatin-Mediated Ototoxicity

Antioxidants, 2020
Cisplatin is a widely used chemotherapeutic drug for treating various solid tumors. Ototoxicity is a major dose-limiting side effect of cisplatin, which causes progressive and irreversible sensorineural hearing loss.
Junyeong Yi, Tae Su Kim, Jhang Ho Pak, Jong Woo Chung   +3 more
doaj   +1 more source

New Impedance Field Telemetry Heat Map for Assessing Electrode Array in MED‐EL Cochlear Implants

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 2, April 2026.
ABSTRACT Objective To compare MED‐EL's new impedance field telemetry (IFT) heat map interface for confirmation of surgical placement of the electrode array to conventional imaging. Methods A retrospective study was completed on 35 patients who received MED‐EL cochlear implants between 2017 and 2024 for whom both IFT and radiologic data were available ...
Christine J. Colasacco, Samantha Morgan, Regina Albinus, Rivka Bornstein, Katrina R. Stidham   +4 more
wiley   +1 more source

Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies.

Cold Spring Harbor Perspectives in Medicine, 2018
Ototoxicity refers to damage of inner ear structures (i.e., the cochlea and vestibule) and their function (hearing and balance) following exposure to specific in-hospital medications (i.e., aminoglycoside antibiotics, platinum-based drugs), as well as a ...
C. Kros, P. Steyger
semanticscholar   +1 more source

Auditory Neuropathy: Challenges and Significant Progress in Diagnosis and Treatment

Advanced Therapeutics, Volume 9, Issue 3, March 2026.
Auditory neuropathy is a complex disorder that causes sensorineural hearing impairment in patients. Recently, breakthrough progress has been made in the gene therapy of auditory neuropathy. This review focuses on auditory neuropathy, covering its pathophysiology, etiology, epidemiology, clinical manifestations, diagnostic techniques, treatment ...
Wen Xie, Ling Lu, Busheng Tong, Lian Fang, Qingqing Dai, Xiaowan Chen, Jieyu Qi, Xiaoyun Qian, Xia Gao, Renjie Chai, Jun Yang, Maoli Duan   +11 more
wiley   +1 more source

Which Environmental Pollutants Are Toxic to Our Ears?—Evidence of the Ototoxicity of Common Substances

Toxics
Ototoxicity refers to the adverse effects of substances on auditory or vestibular functions. This study examines the evidence of ototoxicity’s association with exposure to common environmental pollutants, as documented in toxicological profiles by the ...
Gregory M. Zarus, Patricia Ruiz, Rae Benedict, Stephan Brenner, Krystin Carlson, Layna Jeong, Thais C. Morata   +6 more
doaj   +1 more source

Ursolic acid protects against cisplatin-induced ototoxicity by inhibiting oxidative stress and TRPV1-mediated Ca2+-signaling

International Journal of Molecular Medicine, 2020
Cisplatin (CDDP) is widely used in clinical settings for the treatment of various cancers. However, ototoxicity is a major side effect of CDDP, and there is an associated risk of irreversible hearing loss.
Y. Di, T. Xu, Yuan Tian, Tingting Ma, Donghao Qu, Yan Wang, Yuhan Lin, D. Bao, Li Yu, Shuangyue Liu, Aimei Wang   +10 more
semanticscholar   +1 more source

Society for Maternal‐Fetal Medicine Consult Series #76: Cancer in pregnancy

Pregnancy, Volume 2, Issue 2, March 2026.
Abstract Approximately one in 1000 pregnancies is complicated by the diagnosis of cancer each year, and the incidence of cancer among reproductive‐age individuals is increasing. Management of a pregnant person with cancer can be complex and warrants a multidisciplinary approach to care.
Society for Maternal‐Fetal Medicine (SMFM), Moti Gulersen, Clarissa Bonanno, Justin S. Brandt, Stephanie Pierce, Elyce H. Cardonick, SMFM Publications Committee   +6 more
wiley   +1 more source

Severe Hearing Loss in the World's First Successfully Captive‐Born Yangtze Finless Porpoise: Impact of High Underwater Sound Exposure and Congenital Hearing Disorders

Integrative Zoology, Volume 21, Issue 2, Page 331-342, March 2026.
The audiogram of the world's first successfully captive‐born Yangtze finless porpoise was on average 40 dB higher than conspecifics. Congenital hearing disorders and noise exposure may be the primary cause of porpoise's hearing loss. ABSTRACT Aquariums globally have seen significant growth in recent decades.
Zhitao Wang, Tomonari Akamatsu, Kexiong Wang, Ding Wang   +3 more
wiley   +1 more source

Differential effect of targeting cisplatin-induced nitrative stress using MnTBAP in auditory and cancer cells

Current Research in Toxicology
Ototoxicity is a major dose-limiting side effect of cisplatin, a highly effective anti-cancer drug used to treat many solid tumors. Oxidative stress plays a central role in mediating cisplatin-induced ototoxicity.
Shomaila Mehmood, Pankaj Bhatia, Nicole Doyon-Reale, Samson Jamesdaniel   +3 more
doaj   +1 more source

Clinical aspects of hearing loss associated with cisplatin therapy – a review [PDF]

Romanian Journal of Military Medicine, 2014
Introduction: Cisplatin is a well known platinum-based chemotherapeutic agent used for the treatment of diverse malignant tumours. A frequent side effect of cisplatin therapy is ototoxicity.
Felician Chirteş
doaj