Results 81 to 90 of about 24,961 (203)
JMIR mHealth and uHealth, 2020 BackgroundTuberculosis (TB) affects millions of people worldwide and is treated with medication including aminoglycosides and polypeptides. Individuals respond differently to medications as a result of their genetic inheritance.
Hollander, Cara +2 more
doaj +1 more source
International Journal of Environmental Research and Public Health, 2020 The study was an initial exploration of the current ototoxicity assessment and management practices by audiologists in South Africa. An exploratory survey research methodology through a cross-sectional research design was adopted where audiologists were ...
K. Khoza-Shangase, N. Masondo
semanticscholar +1 more source
The FASEB Journal, Volume 40, Issue 4, 28 February 2026.Comparative transcriptomic, proteomic, and metabolomic analyses of reduced (NRH, NMNH) versus oxidized (NR, NMN) NAD+ precursors reveal that NRH and NMNH induce broader and more potent transcriptomic, proteomic, and metabolomic changes. Although all precursors increase NAD+ pathway metabolites, reduced precursors uniquely elicit a pseudo‐stress ...
Kasper T. Vinten +10 more
wiley +1 more source
Ototoxicity: A Challenge in Diagnosis and Treatment
Journal of Audiology & Otology, 2018 Ototoxicity is the pharmacological adverse reaction affecting the inner ear or auditory nerve, characterized by cochlear or vestibular dysfunction. The panorama of drug-induced hearing loss has widened over last few decades. Although ototoxic medications
Purushothaman Ganesan +5 more
semanticscholar +1 more source
Relationship Between Serum Ferritin Level and Amikacin Ototoxicity
Oman Medical Journal, 2012 Objectives: Aminoglycosides are highly effective against bacteria but have serious side-effects including ototoxicity and nephrotoxicity. One of the theories in aminoglycosides ototoxicity is that Iron-aminoglycoside complex causes ototoxicity by ...
Mohammad Shayaninasab +3 more
doaj
The genetic vulnerability to cisplatin ototoxicity: a systematic review
Scientific Reports, 2019 Ototoxicity is one of the major side-effects of platinum-based chemotherapy, in particular cisplatin (cis-diammine dichloroplatinum II). To our knowledge, no systematic review has previously provided a quantitative summary estimate of the impact of ...
E. Tserga +7 more
semanticscholar +1 more source
Advanced Science, Volume 13, Issue 7, 3 February 2026.This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun +15 more
wiley +1 more source
An optimized, clinically relevant mouse model of cisplatin‐induced ototoxicity
Hearing Research, 2019 Cisplatin‐induced ototoxicity results in significant, permanent hearing loss in pediatric and adult cancer survivors. Elucidating the mechanisms underlying cisplatin‐induced hearing loss as well as the development of therapies to reduce and/or reverse ...
K. Fernandez +3 more
semanticscholar +1 more source
Novel Antifungal Scaffold Targeting Tubulin Overcomes Sclerotinia Sclerotiorum Resistance
Advanced Science, Volume 13, Issue 8, 9 February 2026.Addressing pesticide resistance, novel chromone‐acylhydrazone hybrids targeting fungal tubulin are synthesized. Compound G24 potently inhibited S. sclerotiorum (EC50 = 0.21µg mL−1) and demonstrated enhanced field performance via microencapsulation, offering a sustainable strategy against resistance and for global food security.
Lihui Shao +5 more
wiley +1 more source
The efficacy of strategies used to minimise or prevent Cisplatin-induced ototoxicity in patients
South African Journal of Oncology, 2019 Background: Hearing loss is a major side effect of cisplatin-based chemotherapy. With a large burden of cancer in developing countries, an evidence-based approach to prevention of cisplatin-induced hearing loss (ototoxicity) is pertinent.
Zenzo S. Chakara, Lebogang Ramma
doaj +1 more source