Results 1 to 10 of about 18,941 (209)
The Stability of Ouabain in Aqueous Solution [PDF]
The Journal of the American Pharmaceutical Association (1912), 1914 n ...
Chas.C. Haskell, W.A. Doeppers
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Effects of Renal Denervation on Ouabain-Induced Hypertension in Rats [PDF]
International Journal of HypertensionBackground. Ouabain, a Na+, K+-ATPase inhibitor, is elevated in hypertensive patients. Evidence suggests ouabain contributes to hypertension mainly through activation of the sympathetic nervous system (SNS).
Minna Tang +6 more
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Ouabain Counteracts Retinal Ganglion Cell Death Through Modulation of BDNF and IL-1 Signaling Pathways [PDF]
Brain SciencesBackground: Ouabain is a steroid hormone that binds to the sodium pump (Na+, K+-ATPase) at physiological (nanomolar) concentrations, activating different signaling pathways.
Amanda Candida da Rocha Oliveira +8 more
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Effects of ouabain on vascular reactivity [PDF]
Brazilian Journal of Medical and Biological Research, 1997 Ouabain is an endogenous substance occurring in the plasma in the nanomolar range, that has been proposed to increase vascular resistance and induce hypertension. This substance acts on the a-subunit of Na+,K+-ATPase inhibiting the Na+-pump activity.
Vassallo D.V. +3 more
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OUABAIN OR g-STROPHANTHIN [PDF]
Journal of Biological Chemistry, 1932 Walter A. Jacobs, Newell M. Bigelow
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Ouabain at nanomolar concentrations is cytotoxic for biliary tract cancer cells.
PLoS ONE, 2023 Biliary tract cancer is a deadly disease with limited therapeutic options. Ouabain is a well-known inhibitor of the pumping function of Na+/K+-ATPase, though there is evidence that low concentrations of ouabain lead to a reduction of cell viability of ...
Christian Mayr +12 more
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Radioimmunoassays, Ouabain-Like Material, and Ouabain [PDF]
Hypertension, 2005 To the Editor: We read with interest the article by Bauer et al1 on the changes in the plasma concentration of a ouabain-like compound associated with vigorous exercise in both humans and dogs. The authors comment on the result that is most striking to us, namely the remarkably high concentrations of the immunoassayable substance achieved without ...
Philip J. Hilton, W. McKinnon
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Current Issues in Molecular Biology, 2023 Ouabain, an organic compound with the ability to strengthen the contraction of the heart muscle, was originally derived from plants. It has been observed that certain mammalian species, including humans, naturally produce ouabain, leading to its ...
Jacqueline Martínez-Rendón +6 more
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Neuroinflammation and Neutrophils: Modulation by Ouabain [PDF]
Frontiers in Pharmacology, 2022 Cardiotonic steroids are natural compounds that present many physiological and pharmacological functions. They bind Na+/K+-ATPase (NKA) modifying cellular ion concentration and trigger cell signaling mechanisms without altering ion balance. These steroids are known to modulate some immune responses, including cytokine production, neutrophil migration ...
Jacqueline Alves Leite +5 more
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Cardiac Glycoside Ouabain Exerts Anticancer Activity via Downregulation of STAT3
Frontiers in Oncology, 2021 Cardiac glycosides are plant-derived steroid-like compounds which have been used for the treatment of cardiovascular diseases. Ouabain, a cardiotonic steroid and specific Na+/K+-ATPase inhibitor, has been rediscovered for its potential use in the ...
Jie Du +5 more
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