Results 1 to 10 of about 18,820 (207)

The Stability of Ouabain in Aqueous Solution [PDF]

The Journal of the American Pharmaceutical Association (1912), 1914
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Chas.C. Haskell, W.A. Doeppers
openalex   +4 more sources

Effects of Renal Denervation on Ouabain-Induced Hypertension in Rats [PDF]

International Journal of Hypertension
Background. Ouabain, a Na+, K+-ATPase inhibitor, is elevated in hypertensive patients. Evidence suggests ouabain contributes to hypertension mainly through activation of the sympathetic nervous system (SNS).
Minna Tang, Jialu Hu, Wenshu Li, Ningzhi Zhang, Sisi Ning, Yan Yan, Zhaoqiang Cui   +6 more
doaj   +2 more sources

Ouabain Counteracts Retinal Ganglion Cell Death Through Modulation of BDNF and IL-1 Signaling Pathways [PDF]

Brain Sciences
Background: Ouabain is a steroid hormone that binds to the sodium pump (Na+, K+-ATPase) at physiological (nanomolar) concentrations, activating different signaling pathways.
Amanda Candida da Rocha Oliveira, Camila Saggioro Figueiredo, Ícaro Raony, Juliana Salles Von-Held-Ventura, Marcelo Gomes Granja, Thalita Mázala-de-Oliveira, Vinícius Henrique Pedrosa-Soares, Aline Araujo dos Santos, Elizabeth Giestal-de-Araujo   +8 more
doaj   +2 more sources

Exploration of Circadian Clock-Related Genes in the Pathogenesis of Psoriatic Arthritis to Identify Potential Therapeutic Targets From Multi-Omics Insight: A Mendelian Randomization Study. [PDF]

Int J Rheum Dis
ABSTRACT Background Circadian rhythms have been shown to play a significant role in the etiology and progression of immune‐related morbidities, including cancer and autoimmune diseases. As an autoimmune disorder, psoriatic arthritis (PsA) has been underexplored in the context of circadian rhythms.
Liu A, Huoshen W, Wang Y, Yi S, Qin Z.
europepmc   +2 more sources

Effects of ouabain on vascular reactivity [PDF]

Brazilian Journal of Medical and Biological Research, 1997
Ouabain is an endogenous substance occurring in the plasma in the nanomolar range, that has been proposed to increase vascular resistance and induce hypertension. This substance acts on the a-subunit of Na+,K+-ATPase inhibiting the Na+-pump activity.
Vassallo D.V., E. Songu-Mize, L.V. Rossoni, S.M.C. Amaral   +3 more
doaj   +5 more sources

Target Identification of Marine Natural Product Odoamide:Odoamide Induces Apoptotic Cell Death by Targeting ATPase Na⁺/K⁺ Transporting Subunit Alpha 1 (ATP1A1). [PDF]

Chembiochem
Odoamide, a member of the aurilide‐family, exhibits highly potent cytotoxicity against various cancer cell lines. This study clarifies the target protein and MOA of odoamide by an affinity‐based methodology, followed by analyses of the binding protein and odoamide‐resistant cells.
Katsumata R, Kamiyama H, Sagane K, Yamamoto Y, Azuma H, Nishibata K, Kotake Y, Nakano S, Okubo S, Teruya T, Okuda A, Takase Y.   +11 more
europepmc   +2 more sources

Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD [PDF]

Journal of Neuroinflammation
There is an intrinsic relationship between psychiatric disorders and neuroinflammation, including bipolar disorder. Ouabain, an inhibitor of Na+/K+-ATPase, has been implicated in the mouse model with manic-like behavior. However, the molecular mechanisms
Tzu-Yun Wang, Eddie Feng-Ju Weng, Yun-Chen Hsu, Lu-Ping Shiu, Teng-Wei Huang, Hsuan-Cheng Wu, Jau-Shyong Hong, Shao-Ming Wang   +7 more
doaj   +2 more sources

OUABAIN OR g-STROPHANTHIN [PDF]

Journal of Biological Chemistry, 1932
Walter A. Jacobs, Newell M. Bigelow
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Ouabain at nanomolar concentrations is cytotoxic for biliary tract cancer cells.

PLoS ONE, 2023
Biliary tract cancer is a deadly disease with limited therapeutic options. Ouabain is a well-known inhibitor of the pumping function of Na+/K+-ATPase, though there is evidence that low concentrations of ouabain lead to a reduction of cell viability of ...
Christian Mayr, Tobias Kiesslich, Dino Bekric, Marlena Beyreis, Michael Kittl, Celina Ablinger, Elen Neureiter, Martin Pichler, Felix Prinz, Markus Ritter, Daniel Neureiter, Martin Jakab, Heidemarie Dobias   +12 more
doaj   +2 more sources

Radioimmunoassays, Ouabain-Like Material, and Ouabain [PDF]

Hypertension, 2005
To the Editor: We read with interest the article by Bauer et al1 on the changes in the plasma concentration of a ouabain-like compound associated with vigorous exercise in both humans and dogs. The authors comment on the result that is most striking to us, namely the remarkably high concentrations of the immunoassayable substance achieved without ...
Philip J. Hilton, W. McKinnon
openaire   +2 more sources