Results 1 to 10 of about 38,478 (200)

Ouabain alleviates Mycobacterium abscessus-triggered inflammatory responses through dual regulation of NLRP3 inflammasome activity and M1 macrophage polarization [PDF]

Frontiers in Immunology
IntroductionMycobacterium abscessus (M. abscessus) is a highly drug-resistant pathogen responsible for chronic pulmonary inflammation in humans. The cardiac glycoside ouabain exhibits broad anti-inflammatory effects in various disease models, but its ...
Nan Li, Nan Li, Nan Li, Songqiang Huang, Songqiang Huang, Xing Shi, Kuo Lu, Kuo Lu, Xiu Yu, Chen Qiu, Rongchang Chen   +10 more
doaj   +3 more sources

Cardiac Glycoside Ouabain Exerts Anticancer Activity via Downregulation of STAT3

Frontiers in Oncology, 2021
Cardiac glycosides are plant-derived steroid-like compounds which have been used for the treatment of cardiovascular diseases. Ouabain, a cardiotonic steroid and specific Na+/K+-ATPase inhibitor, has been rediscovered for its potential use in the ...
Jie Du, Jie Du, Lijun Jiang, Fuqiang Chen, Huantao Hu, Meijuan Zhou   +5 more
doaj   +2 more sources

A low concentration of ouabain (0.18 µg/kg) enhances hypertension in spontaneously hypertensive rats by inhibiting the Na+ pump and activating the renin-angiotensin system [PDF]

Brazilian Journal of Medical and Biological Research, 2010
We investigated the effects of low ouabain concentrations on systolic (SAP) and diastolic (DAP) arterial pressures and on pressor reactivity in 3-month-old male spontaneously hypertensive rats (SHR). Arterial blood pressure (BP) and pressor reactivity to
F.D.M. Siman, I. Stefanon, D.V. Vassallo, A.S. Padilha   +3 more
doaj   +2 more sources

Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain

Frontiers in Physiology, 2017
Since the discovery of ouabain as a cardiotonic steroid hormone present in higher mammals, research about it has progressed rapidly and several of its physiological and pharmacological effects have been described.
Luiz H. A. Cavalcante-Silva, Éssia de Almeida Lima, Deyse C. M. Carvalho, José M. de Sales-Neto, Anne K. de Abreu Alves, José G. F. M. Galvão, Juliane S. de França da Silva, Sandra Rodrigues-Mascarenhas, Sandra Rodrigues-Mascarenhas, Sandra Rodrigues-Mascarenhas   +9 more
doaj   +2 more sources

Ouabain – a double-edged sword in tumor development and progression? a review of half a century [PDF]

Frontiers in Physiology
Since their first discovery as potential anti-cancer drugs there is increasing evidence that cardiotonic steroids e.g., Ouabain have anti-tumor properties by interacting with their natural receptor the Na+-K+-ATPase (NKA) and by inducing diverse ...
Heidrun Weidemann, Alaa Daoud Sarsour, Alaa Daoud Sarsour, Chaya Brodie, Chaya Brodie   +4 more
doaj   +2 more sources

Ouabain Suppresses IL-6/STAT3 Signaling and Promotes Cytokine Secretion in Cultured Skeletal Muscle Cells

Frontiers in Physiology, 2020
The cardiotonic steroids (CTS), such as ouabain and marinobufagenin, are thought to be adrenocortical hormones secreted during exercise and the stress response. The catalytic α-subunit of Na,K-ATPase (NKA) is a CTS receptor, whose largest pool is located
Sergej Pirkmajer, Katja Bezjak, Urška Matkovič, Klemen Dolinar, Lake Q. Jiang, Katarina Miš, Katarina Gros, Kseniya Milovanova, Katja Perdan Pirkmajer, Katja Perdan Pirkmajer, Tomaž Marš, Leonid Kapilevich, Leonid Kapilevich, Alexander V. Chibalin   +13 more
doaj   +2 more sources

Regulatory Ouabain Action on Excitatory Transmission in Rat Hippocampus: Facilitation of Synaptic Responses and Weakening of LTP [PDF]

Biomolecules
Cardiotonic steroids (CTS), including the endogenous compound ouabain, modulate neuronal Na/K-ATPase (NKA) activity in a concentration-dependent manner, affecting neuronal survival and function.
Yulia D. Stepanenko, Dmitry A. Sibarov, Sergei M. Antonov   +2 more
doaj   +2 more sources

Ouabain Increases Gap Junctional Communication in Epithelial Cells

Cellular Physiology and Biochemistry, 2014
Background/Aims: The finding that endogenous ouabain acts as a hormone prompted efforts to elucidate its physiological function. In previous studies, we have shown that 10 nM ouabain (i.e., a concentration within the physiological range) modulates cell ...
Arturo Ponce, Isabel Larre, Aida Castillo, Refugio García-Villegas, Adrián Romero, Catalina Flores-Maldonado, Jacqueline Martinez-Rendón, Rubén Gerardo Contreras, Marcelino Cereijido   +8 more
doaj   +2 more sources

Ouabain Modulates Zymosan-Induced Peritonitis in Mice

Mediators of Inflammation, 2015
Ouabain, a potent inhibitor of the Na+, K+-ATPase, was identified as an endogenous substance. Recently, ouabain was shown to affect various immunological processes.
Jacqueline Alves Leite, Anne Kaliery De Abreu Alves, José Guilherme Marques Galvão, Mariana Pires Teixeira, Luiz Henrique Agra Cavalcante-Silva, Cristoforo Scavone, Alexandre Morrot, Vivian Mary Rumjanek, Sandra Rodrigues-Mascarenhas   +8 more
doaj   +2 more sources

Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents. [PDF]

PLoS ONE, 2013
Modulation of the DNA repair pathway is an emerging target for the development of anticancer drugs. DNA interstrand cross-links (ICLs), one of the most severe forms of DNA damage caused by anticancer drugs such as cisplatin and mitomycin C (MMC ...
Dong Wha Jun, Mihwa Hwang, Hyun Jung Kim, Soo Kyung Hwang, Sunshin Kim, Chang-Hun Lee   +5 more
doaj   +2 more sources