Results 91 to 100 of about 37,475 (253)

Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Aging causes accumulation of p16⁺ senescent cells that promote inflammation and dysfunction. Multi‐omics analyses reveal striking sex differences in senescent cell burden and clearance: females accumulate more p16⁺ cells, especially in the liver, and their removal rejuvenates molecular and functional profiles.
Yao Lin, Boshi Wang, Mengling Huang, Justina C. Wolters, Marco Demaria   +4 more
wiley   +1 more source

Cellular mechanisms of potassium homeostasis in the mammalian nervous system [PDF]

, 1987
Double-barrelled ion-sensitive microelectrodes were used to measure changes in the intracellular activities of K+, Na+, and Cl- (aKi, aNai, aCli) in neurones of rat sympathetic ganglia and in glial cells of slices from guinea-pig olfactory cortex.
Ballanyi, Klaus, Grafe, Peter
core   +1 more source

Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu, Bingxing An, Jumei Zheng, Qiao Wang, Zhirui Yang, Zhengda Li, Dawei Liu, Fan Ying, Jie Wen, Lingzhao Fang, Guiping Zhao   +10 more
wiley   +1 more source

Na+,K+-ATPase is the membrane receptor of hormone ouabain

Communicative & Integrative Biology, 2010
At 10 nM, ouabain elicits changes in cell contacts, which are independent and usually in opposite direction to effects occurring at μM levels, suggesting that these depend on entirely different mechanisms.1 However, this does not discard the possibility ...
Isabel Larre, Marcelino Cereijido
doaj   +1 more source

Adynamia episodica hereditaria with myotonia: A non-inactivating sodium current and the effect of extracellular pH [PDF]

, 1987
To study the mechanism of periodic paralysis, we investigated the properties of intact muscle fibers biopsied from a patient who had adynamia episodica hereditaria with electromyographic signs of myotonia.
Aickin, Becker, Bekény, Bradley, Bretag, Buchthal, Caldwell, Carson, Clausen, Drager, French, Gamstorp, Grafe, Grafe, Helweg-Larsen, Heuser, Hille, Hoff van't, Krull, Kwieciński, Kwieciński, Lehmann-Horn, Lehmann-Horn, Lehmann-Horn, Lewis, McArdle, McComas, Meulen van der, Ricker, Ricker, Riggs, Ruff, Rüdel, Rüdel, Stafstrom, Subramony, Sugimori, Thomas   +37 more
core   +1 more source

Bioactivity‐Guided Isolation of β‐Sitosterol From Terminalia glabrescens as a Potent Anti‐Zika Virus Agent

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Zika virus (ZIKV) infection remains a global health concern due to its neurological complications and the lack of specific drugs or vaccines. This study investigated the anti‐ZIKV potential of an ethanolic extract from Terminalia glabrescens leaves.
Rosângela Santos Pereira, Priscilla Rodrigues Valadares Campana, Vivian Vasconcelos Costa, Vinícius Gonçalves Maltarollo, Rodrigo Maia de Pádua, José Hugo Sousa de Gomes, Grasiely Farias de Sousa, José Dias de Souza Filho, Daniele da Glória de Souza, Mauro Martins Teixeira, Fernão Castro Braga   +10 more
wiley   +1 more source

Comparative analysis of the mechanokinetics of contractile activity of myometrium smooth muscles under calixarene C-99 and ouabain action

Біологічні студії, 2014
It is known that calix[4]arene with cipher C-99 selectively and with high affinity capable of inhibiting the Na+, K+-ATPase (compared with a known inhibitor of this enzyme – ouabain) of smooth muscle cells plasma membrane preparations.
O. V. Tsymbalyuk
doaj   +1 more source

Endogenous bioelectric currents promote differentiation of the mammalian lens [PDF]

, 2018
Acknowledgements We are grateful to Kevin S. Mackenzie in our imaging core facility. This work was supported by the University of Aberdeen (at which the majority of the experimental work was conducted).
Andley, Banno, Barrett, Bassnett, Bhat, Bhuyan, Blackiston, Bortner, Call, Cao, Chen, Chen, Chen, Eperon, Franco, Gwon, Gwon, Ibaraki, Kalous, Kolosova, Korlimbinis, Lampi, Lampi, Lee, Liu, Lois, Lovicu, Mathias, McCaig, Park, Patterson, Piatigorsky, Rajagopal, Robinson, Robinson, Sanderson, Sellitto, Shestopalov, Shestopalov, Sundelacruz, Sundelacruz, Sundelacruz, Thylefors, Ueda, Vaghefi, Wang, Wang, Wang, White, Wind, Wormstone, Yang, Zhao   +52 more
core   +1 more source

Changes in intracellular ion activities induced by adrenaline in human and rat skeletal muscle [PDF]

, 1988
To study the stimulating effect of adrenaline (ADR) on active Na+/K+ transport we used double-barrelled ion-sensitive micro-electrodes to measure the activities of extracellular K+ (aKe) and intracellular Na+ (aNai) in isolated preparations of rat soleus
A Chinet, C Steinhagen, CO Lee, G Pfliegler, H Zemkova, HG Glitsch, JA Wasserstrom, JF Brooks, K Ballanyi, K Ballanyi, Klaus Ballanyi, LM Camacho, M Dockry, M Désilets, ME Williams, MK Rasmussen, P Grafe, P Wang, PE Bendheim, Peter Grafe, R Weingart, RC Thomas, RM Rosa, RY Tsien, S-S Sheu, T Clausen, T Clausen, T Clausen, T Clausen, WE Kozachuk   +29 more
core   +1 more source

Ouabain inhibition of Na/K-ATPase across the retina prevents signed refractive compensation to lens-induced defocus, but not default ocular growth in young chicks [v1; ref status: indexed, http://f1000r.es/rt]

F1000Research, 2013
Purpose: The relevance of retinal integrity and energy pathways to ocular growth and induction of refractive errors has seldom been investigated. Thus, we used ouabain to target the channels that are essential for the maintenance of membrane potentials ...
Melanie J Murphy, Sheila Gillard Crewther   +1 more
doaj   +1 more source